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VRK2 encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases.
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GSK3beta may inhibit VRK2 catalytic activity by disrupting its flexibility. The inhibition of VRK2 catalytic activity by GSK3beta may also inhibit VRK2-induced degradation of TRiC (show MARVELD2 Antibodies), which could suppress polyQ-expanded Htt (show HTT Antibodies) aggregation.
The combined analysis confirmed evidence of genome-wide significant associations in the Han Chinese population for three loci, at 2p16.1 (rs1051061, in an exon of VRK2, P=1.14 x 10-12, odds ratio (OR)=1.17), 6p22.1 (rs115070292 in an intron of GABBR1, P=4.96 x 10-10, OR=0.77) and 10q24.32 (rs10883795 in an intron of AS3MT, P=7.94 x 10-10, OR=0.87; rs10883765 at an intron of ARL3, P=3.06 x 10-9, OR=0.87).
VRK1 (show VRK1 Antibodies) AND VRK2 expression are predictive of tumor response to neoadjuvant chemoradiation therapy in rectal adenocarcinoma.
Reduced VRK2 mRNA levels are involved in the underlying mechanisms in schizophrenia spectrum disorders.
These data support a model in which vaccinia virus B1 and human VRK2 share additional substrates important for the replication of cytoplasmic poxviruses.
we replicated one known signal in PAX8 (show PAX8 Antibodies) (2.6 minutes per allele, 95% CI [1.9, 3.2], P = 5.7x10-16) and identified and replicated two novel associations at VRK2 (2.0 minutes per allele, 95% CI [1.3, 2.7], P = 1.2x10-9; and 1.6 minutes per allele, 95% CI [1.1, 2.2], P = 7.6x10-9)
The data provides further evidence for the genetic contributions of VRK2 rs2312147 to schizophrenia susceptibility especially in Europeans, while further replication analyses in Asian populations are still needed. [meta-analysis]
Our data provide preliminary evidence that the VRK2 gene might play a major role in the development of SCZ in the Northwest Chinese Han population.
data may provide evidence for the effect of VRK2 on WM connectivity in patients with schizophrenia
Findings suggest that ubiquitin-specific protease 25 (USP25 (show USP25 Antibodies)) as a VRK2 substrate that acts on TRiC (show MARVELD2 Antibodies) deubiquitination.
This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, leukocytes, fetal liver, and carcinomas. Its protein localizes to the endoplasmic reticulum and has been shown to phosphorylate casein and undergo autophosphorylation. Multiple alternatively spliced transcript variants have been found for this gene.
vaccinia related kinase 2
, serine/threonine-protein kinase VRK2
, vaccinia virus B1R-related kinase 2
, vaccinia virus BIR kinase related kinase 2
, vaccinia-related kinase 2