anti-Vaccinia Related Kinase 2 (VRK2) Antibodies

VRK2 encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. Additionally we are shipping VRK2 Proteins (5) and VRK2 Kits (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
VRK2 7444 Q86Y07
VRK2 69922 Q8BN21
VRK2 360991  
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Top anti-VRK2 Antibodies at antibodies-online.com

Showing 10 out of 57 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from Jurkat cells, using VRK2 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg 2 to 3 Days
$302.50
Details
Human Goat Un-conjugated ELISA, WB   100 μg 6 to 7 Days
$429.84
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, WB   100 μL 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated IP, WB VRK2 MaxPab rabbit polyclonal antibody. Western Blot analysis of VRK2 expression in rat brain. VRK2 MaxPab rabbit polyclonal antibody. Western Blot analysis of VRK2 expression in mouse lung. 100 μL 11 to 12 Days
$425.71
Details
Human Rabbit Un-conjugated ELISA, IHC, WB Western blot analysis of VRK2 expression in Jurkat cell lysate,The lane on the left is treated with the antigen-specific peptide. ABIN6273820 at 1/100 staining Mouse liver tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. 100 μL 11 to 12 Days
$390.77
Details
Human Mouse Un-conjugated IF, RNAi, ELISA, WB Immunofluorescence of monoclonal antibody to VRK2 on HeLa cell. [antibody concentration 10 ug/ml] VRK2 monoclonal antibody (M01), clone 3B10 Western Blot analysis of VRK2 expression in K-562 . 100 μg 11 to 12 Days
$440.00
Details
Human Goat Un-conjugated ELISA, WB ABIN4902794 (2µg/ml) staining of K562 nuclear lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μL 11 to 13 Days
$457.22
Details
Mouse Rabbit Un-conjugated WB Western blot analysis in mouse liver tissue lysates (35ug/lane). 400 μL 2 to 3 Days
$515.63
Details
Human Rabbit Un-conjugated ELISA, WB   100 μL Available
$363.46
Details
Human Rabbit Un-conjugated WB Lane 1: mouse embryo lysates Lane 2: mouse liver lysates probed with VRK2 Polyclonal Antibody, Unconjugated  at 1:300 dilution and 4˚C overnight incubation. Followed by conjugated secondary antibody incubation at 1:10000 for 60 min at 37˚C. 100 μL 3 to 7 Days
$317.90
Details

More Antibodies against VRK2 Interaction Partners

Human Vaccinia Related Kinase 2 (VRK2) interaction partners

  1. our work reveals the regulation of dysbindin by VRK2, providing the association of these two proteins, which are commonly implicated in schizophrenia

  2. Structural characterization of human vaccinia-related kinases, VRK1 and VRK2, bound to small-molecule inhibitors, has been reported.

  3. a novel insight into the oncogenic activity of VRK2-Akt complexes in the lysosomes via modulation of autophagy

  4. VRK2 is suggested as a candidate gene for neurological disorders through its role in signaling pathway, the neuronal loss and stress response.

  5. GSK3beta may inhibit VRK2 catalytic activity by disrupting its flexibility. The inhibition of VRK2 catalytic activity by GSK3beta may also inhibit VRK2-induced degradation of TRiC, which could suppress polyQ-expanded Htt aggregation.

  6. The combined analysis confirmed evidence of genome-wide significant associations in the Han Chinese population for three loci, at 2p16.1 (rs1051061, in an exon of VRK2, P=1.14 x 10-12, odds ratio (OR)=1.17), 6p22.1 (rs115070292 in an intron of GABBR1, P=4.96 x 10-10, OR=0.77) and 10q24.32 (rs10883795 in an intron of AS3MT, P=7.94 x 10-10, OR=0.87; rs10883765 at an intron of ARL3, P=3.06 x 10-9, OR=0.87).

  7. VRK1 AND VRK2 expression are predictive of tumor response to neoadjuvant chemoradiation therapy in rectal adenocarcinoma.

  8. Reduced VRK2 mRNA levels are involved in the underlying mechanisms in schizophrenia spectrum disorders.

  9. These data support a model in which vaccinia virus B1 and human VRK2 share additional substrates important for the replication of cytoplasmic poxviruses.

  10. we replicated one known signal in PAX8 (2.6 minutes per allele, 95% CI [1.9, 3.2], P = 5.7x10-16) and identified and replicated two novel associations at VRK2 (2.0 minutes per allele, 95% CI [1.3, 2.7], P = 1.2x10-9; and 1.6 minutes per allele, 95% CI [1.1, 2.2], P = 7.6x10-9)

  11. The data provides further evidence for the genetic contributions of VRK2 rs2312147 to schizophrenia susceptibility especially in Europeans, while further replication analyses in Asian populations are still needed. [meta-analysis]

  12. Our data provide preliminary evidence that the VRK2 gene might play a major role in the development of SCZ in the Northwest Chinese Han population.

  13. data may provide evidence for the effect of VRK2 on WM connectivity in patients with schizophrenia

  14. Findings suggest that ubiquitin-specific protease 25 (USP25) as a VRK2 substrate that acts on TRiC deubiquitination.

  15. VRK2 is crucial to regulate the ubiquitination-proteosomal degradation of eukaryotic chaperonin TCP-1 ring complex

  16. Data from molecular dynamic simulations suggest that bivalent cations play key structural roles in stabilization of VRK1/VRK2; bivalent cations have no obvious effects on VRK3. These kinases are targets in search for antineoplastic agents. [REVIEW]

  17. Low levels of VRK2A causes an increase in mitochondrial Bax protein level, leading to an increase in the release of cytochrome C and caspase activation, detected by PARP processing.

  18. Generalized epilepsies implicates susceptibility genes: CHRM3 at 1q43, VRK2 at 2p16.1, ZEB2 at 2q22.3, SCN1A at 2q24.3 and PNPO at 17q21.32.

  19. This study analyzed 5 genome-wide supported variants in a Han Chinese sample, and the variant rs2312147 at VRK2 showed significant association, which was confirmed in the meta-analysis combining multiple Asian and European.

  20. Human VRK2 is an active kinase playing a role in regulation of cancer cell invasion through the NFAT pathway and COX-2 expression.

Mouse (Murine) Vaccinia Related Kinase 2 (VRK2) interaction partners

  1. VRK genes play a role during embryonic development of hematopoiesis

VRK2 Antigen Profile

Protein Summary

This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, leukocytes, fetal liver, and carcinomas. Its protein localizes to the endoplasmic reticulum and has been shown to phosphorylate casein and undergo autophosphorylation. Multiple alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with VRK2

  • vaccinia related kinase 2 (VRK2) antibody
  • vaccinia related kinase 2 (Vrk2) antibody
  • 2810003O05Rik antibody
  • AI447698 antibody

Protein level used designations for VRK2

vaccinia related kinase 2 , serine/threonine-protein kinase VRK2 , vaccinia virus B1R-related kinase 2 , vaccinia virus BIR kinase related kinase 2 , vaccinia-related kinase 2

GENE ID SPECIES
100345223 Oryctolagus cuniculus
7444 Homo sapiens
69922 Mus musculus
360991 Rattus norvegicus
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