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VRK2 antibody (AA 151-250) (Biotin)

VRK2 Reactivity: Mouse WB, ELISA, IHC (fro), IHC (p) Host: Rabbit Polyclonal Biotin
Catalog No. ABIN5675137
  • Target See all VRK2 Antibodies
    VRK2 (Vaccinia Related Kinase 2 (VRK2))
    Binding Specificity
    • 14
    • 8
    • 7
    • 6
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    AA 151-250
    Reactivity
    • 32
    • 20
    • 1
    Mouse
    Host
    • 45
    • 2
    • 1
    Rabbit
    Clonality
    • 47
    • 1
    Polyclonal
    Conjugate
    • 16
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This VRK2 antibody is conjugated to Biotin
    Application
    • 38
    • 24
    • 13
    • 13
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Cross-Reactivity
    Mouse
    Predicted Reactivity
    Human,Rat,Chicken
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human VRK2
    Isotype
    IgG
    Top Product
    Discover our top product VRK2 Primary Antibody
  • Application Notes
    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C for 12 months.
    Expiry Date
    12 months
  • Target
    VRK2 (Vaccinia Related Kinase 2 (VRK2))
    Alternative Name
    VRK2 (VRK2 Products)
    Synonyms
    2810003O05Rik antibody, AI447698 antibody, vaccinia related kinase 2 antibody, VRK2 antibody, Vrk2 antibody
    Background

    Synonyms: Serine/threonine-protein kinase VRK2, VRK2, Vaccinia-related kinase 2

    Background: Serine/threonine kinase that regulates several signal transduction pathways. Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes. Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription. Phosphorylates 'Thr-18' of p53/TP53, histone H3, and may also phosphorylate MAPK8IP1. Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins. Downregulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1. Blocks the phosphorylation of ERK in response to ERBB2 and HRAS. Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevant. Isoform 2 phosphorylates 'Thr-18' of p53/TP53, as well as histone H3. Reduces p53/TP53 ubiquitination by MDM2, promotes p53/TP53 acetylation by EP300 and thereby increases p53/TP53 stability and activity.

    Gene ID
    7444
    UniProt
    Q86Y07
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