Vaccinia Related Kinase 2 Proteins (VRK2)

VRK2 encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. Additionally we are shipping VRK2 Antibodies (53) and VRK2 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
VRK2 7444 Q86Y07
Mouse VRK2 VRK2 69922 Q8BN21
Rat VRK2 VRK2 360991  
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Top VRK2 Proteins at

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Insect Cells Human GST tag 5 μg Log in to see 11 to 12 Days
Baculovirus infected Insect Cells Human GST tag   10 μg Log in to see 10 to 12 Days
Insect Cells Human GST tag   10 μg Log in to see 3 to 4 Days

VRK2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,

More Proteins for Vaccinia Related Kinase 2 (VRK2) Interaction Partners

Human Vaccinia Related Kinase 2 (VRK2) interaction partners

  1. VRK2 is suggested as a candidate gene for neurological disorders through its role in signaling pathway, the neuronal loss and stress response.

  2. GSK3beta may inhibit VRK2 catalytic activity by disrupting its flexibility. The inhibition of VRK2 catalytic activity by GSK3beta may also inhibit VRK2-induced degradation of TRiC, which could suppress polyQ-expanded Htt aggregation.

  3. The combined analysis confirmed evidence of genome-wide significant associations in the Han Chinese population for three loci, at 2p16.1 (rs1051061, in an exon of VRK2, P=1.14 x 10-12, odds ratio (OR)=1.17), 6p22.1 (rs115070292 in an intron of GABBR1, P=4.96 x 10-10, OR=0.77) and 10q24.32 (rs10883795 in an intron of AS3MT, P=7.94 x 10-10, OR=0.87; rs10883765 at an intron of ARL3, P=3.06 x 10-9, OR=0.87).

  4. VRK1 AND VRK2 expression are predictive of tumor response to neoadjuvant chemoradiation therapy in rectal adenocarcinoma.

  5. Reduced VRK2 mRNA levels are involved in the underlying mechanisms in schizophrenia spectrum disorders.

  6. These data support a model in which vaccinia virus B1 and human VRK2 share additional substrates important for the replication of cytoplasmic poxviruses.

  7. we replicated one known signal in PAX8 (2.6 minutes per allele, 95% CI [1.9, 3.2], P = 5.7x10-16) and identified and replicated two novel associations at VRK2 (2.0 minutes per allele, 95% CI [1.3, 2.7], P = 1.2x10-9; and 1.6 minutes per allele, 95% CI [1.1, 2.2], P = 7.6x10-9)

  8. The data provides further evidence for the genetic contributions of VRK2 rs2312147 to schizophrenia susceptibility especially in Europeans, while further replication analyses in Asian populations are still needed. [meta-analysis]

  9. Our data provide preliminary evidence that the VRK2 gene might play a major role in the development of SCZ in the Northwest Chinese Han population.

  10. data may provide evidence for the effect of VRK2 on WM connectivity in patients with schizophrenia

  11. Findings suggest that ubiquitin-specific protease 25 (USP25) as a VRK2 substrate that acts on TRiC deubiquitination.

  12. VRK2 is crucial to regulate the ubiquitination-proteosomal degradation of eukaryotic chaperonin TCP-1 ring complex

  13. Data from molecular dynamic simulations suggest that bivalent cations play key structural roles in stabilization of VRK1/VRK2; bivalent cations have no obvious effects on VRK3. These kinases are targets in search for antineoplastic agents. [REVIEW]

  14. Low levels of VRK2A causes an increase in mitochondrial Bax protein level, leading to an increase in the release of cytochrome C and caspase activation, detected by PARP processing.

  15. Generalized epilepsies implicates susceptibility genes: CHRM3 at 1q43, VRK2 at 2p16.1, ZEB2 at 2q22.3, SCN1A at 2q24.3 and PNPO at 17q21.32.

  16. This study analyzed 5 genome-wide supported variants in a Han Chinese sample, and the variant rs2312147 at VRK2 showed significant association, which was confirmed in the meta-analysis combining multiple Asian and European.

  17. Human VRK2 is an active kinase playing a role in regulation of cancer cell invasion through the NFAT pathway and COX-2 expression.

  18. VRK2A can form a high molecular size complex with both MEK1 and KSR1; the KSR1 complex assembled and retained by VRK2A in the endoplasmic reticulum can have a modulatory effect on the signal mediated by MAPK,locally affecting the magnitude of its responses

  19. Common variants at VRK2 show genome-wide significant association with schizophrenia.

  20. Data suggest a role for VRK2A in ErbB2-MAPK signaling.

Mouse (Murine) Vaccinia Related Kinase 2 (VRK2) interaction partners

  1. VRK genes play a role during embryonic development of hematopoiesis

VRK2 Protein Profile

Protein Summary

This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, leukocytes, fetal liver, and carcinomas. Its protein localizes to the endoplasmic reticulum and has been shown to phosphorylate casein and undergo autophosphorylation. Multiple alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with VRK2

  • vaccinia related kinase 2 (VRK2)
  • vaccinia related kinase 2 (Vrk2)
  • 2810003O05Rik protein
  • AI447698 protein

Protein level used designations for VRK2

vaccinia related kinase 2 , serine/threonine-protein kinase VRK2 , vaccinia virus B1R-related kinase 2 , vaccinia virus BIR kinase related kinase 2 , vaccinia-related kinase 2

100345223 Oryctolagus cuniculus
7444 Homo sapiens
69922 Mus musculus
360991 Rattus norvegicus
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