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Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Additionally we are shipping VPS16 Antibodies (35) and many more products for this protein.
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Vps16p is highly expressed in neurons of various brain areas and developmental stages tested; it colocalizes with microtubule associated protein 2, but not glial fibrillary acidic protein (show GFAP Proteins).
VPS16 is a new causative gene for adolescent-onset primary dystonia.
HOPS (show ALPL Proteins) subunit Vps16 recruits Vps33A (show VPS33A Proteins) to the human HOPS (show ALPL Proteins) complex; residues 642-736 are necessary and sufficient for this interaction.
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps16 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Two transcript variants encoding different isoforms have been found for this gene.
vacuolar protein sorting protein 16
, vacuolar protein sorting-associated protein 16 homolog
, vacuolar protein sorting 16 homolog (S. cerevisiae)
, vacuolar protein sorting 16 homolog A