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VPS37A belongs to the VPS37 family, and encodes a component of the ESCRT-I (endosomal sorting complex required for transport I) protein complex, required for the sorting of ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies. Additionally we are shipping VPS37A Antibodies (38) and VPS37A Kits (7) and many more products for this protein.
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HCRP1 is a negative regulator in prostate cancer progression, metastasis and multi-drug resistance.
this study identifies HCRP1 downregulation correlates with tumor stage, nodal metastasis, and poor patient survival in human gastric cancer
The present data indicate that HCRP1 inhibits breast cancer metastasis through downregulating EGFR phosphorylation.
Low HCRP1 expression was found to be of adverse prognostic significance in patients with oral and oropharyngeal squamous cell carcinoma who received preoperative chemoradiotherapy
The missense mutation c.1146A>T in Vps37A causes autosomal recessive complex hereditary spastic paraparesis.
Data show hVps37A mRNA downregulation in ovarian cancer.
Our results strongly suggest that HCRP1 might be a growth inhibitory protein and associated with decreasing the invasion of HCC cells
HCRP1 is a subunit of mammalian ESCRT-I, and its function is essential for lysosomal sorting of EGF receptors.
This gene belongs to the VPS37 family, and encodes a component of the ESCRT-I (endosomal sorting complex required for transport I) protein complex, required for the sorting of ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies. Expression of this gene is downregulated in hepatocellular carcinoma, and mutations in this gene are associated with autosomal recessive spastic paraplegia-53. A related pseudogene has been identified on chromosome 5. Alternatively spliced transcript variants have been found for this gene.
vacuolar protein sorting-associated protein 37A
, vacuolar protein sorting 37A
, hepatocellular carcinoma related protein 1
, Vacuolar protein sorting-associated protein 37A
, ESCRT-I complex subunit VPS37A
, hepatocellular carcinoma-related protein 1
, polyglutamine binding protein 2