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VPS54 encodes for a protein that in yeast forms part of a trimeric vacuolar-protein-sorting complex that is required for retrograde transport of proteins from prevacuoles to the late Golgi compartment.
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Human Polyclonal VPS54 Primary Antibody for WB - ABIN526797
Berruti, Ripolone, Ceriani: USP8, a regulator of endosomal sorting, is involved in mouse acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. in Biology of reproduction 2010
This study demonstrated that the cerebellum is affected by neurodegenerative and inflammatory processes in the Wobbler mouse model of ALS.
Investigation of cells derived from wobbler and Vps54 null mutant embryos demonstrates impaired retrograde transport of the Cholera-toxin B subunit to the trans-Golgi network and mis (show AMH Antibodies)-sorting of mannose-6-phosphate receptors and cargo proteins.
We conclude that a missense mutation in VPS54, an essential component of the Golgi-associated retrograde protein complex, not only prevents the formation of an acrosome but also initiates a cascade of metabolic abnormalities and a stress reaction.
Severely reduced levels of mutant Vps54 and, consequently, of the whole GARP (show LRRC32 Antibodies) complex underlie the phenotype of the wobbler mouse.
Mutation of Vps54 causes motor neuron disease and defective spermiogenesis in the wobbler mouse
This study suggests that VPS54 mutations are not a common cause of Amyotrophic Lateral Sclerosis in Italian population
Golgi-associated retrograde protein orchestrates retrograde transport from endosomes to the trans-Golgi network by promoting vesicle tethering and assembly of SNARE (show NAPA Antibodies) complexes in consecutive, independent steps.[Golgi associated retrograde protein]
Severely reduced levels of mutant Vps54 and, consequently, of the whole GARP (show CNGB1 Antibodies) complex underlie the phenotype of the wobbler mouse.
Golgi associated retrograde protein complex, consisting of the Vps52 (show VPS52 Antibodies), Vps53 (show VPS53 Antibodies), and Vps54 proteins, shows significant conservation between various species but diversification and specialization result in important differences in human cells.
Missorting of cathepsin D (show CTSD Antibodies) in GARP (show CNGB1 Antibodies)-depleted cells results from accumulation of recycling MPRs in a population of light, small vesicles downstream of endosomes.
mutations in VPS54 are not a major cause of ALS (amyotrophic lateral sclerosis)
PMID:12039048 mostly pertains to mouse and rat but contains some general comments about the structure and function of Vps54 homolog in other species, including human.
This gene encodes for a protein that in yeast forms part of a trimeric vacuolar-protein-sorting complex that is required for retrograde transport of proteins from prevacuoles to the late Golgi compartment. As in yeast, mammalian Vps54 proteins contain a coiled-coil region and dileucine motifs. Alternative splicing results in multiple transcript variants encoding different isoforms
tumor antigen SLP-8p homolog
, vacuolar protein sorting-associated protein 54
, hepatocellular carcinoma protein 8
, tumor antigen HOM-HCC-8
, tumor antigen SLP-8p
, vps54-like protein