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VNN2 product is a member of the Vanin family of proteins that share extensive sequence similarity with each other, and also with biotinidase. Additionally we are shipping VNN2 Proteins (6) and many more products for this protein.
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Ovulation is associated with an LH/hCG (show CGA Antibodies)-forskolin-dependent up-regulation of VNN2 mRNA in bovine granulosa cells of preovulatory follicles via the adenyl cyclase (show ADCY1 Antibodies)/cAMP pathway
the GPI-80 CV in the CD16 (show CD16 Antibodies)(hi) population was correlated inversely with the proliferative ability of T cells and the GPI-80 MFI of the CD33 (show CD33 Antibodies)(hi) population was correlated with reactive oxygen species production. These results led us to propose that the pattern of GPI-80 expression in these populations is a simple and useful marker for unusual differentiation, which is related to MDSC functions.
GPI-80 defines a subpopulation of human fetal liver hematopoietic stem/progenitor cells (HSPCs) with self-renewal ability.
DMSO induces neutrophil differentiation and provides suitable conditions for GPI-80 expression; this culture system is a model for the regulation of GPI-80 expression during myeloid differentiation.
GPI-80 positive monocytes belong to a monocyte subpopulation that is superior in phagocytosis and reactive oxygen production, but inferior in antigen presentation
elevated GPI-80 expression is associated with development and progression of thymoma
some of the GPI-80 on pseudopodia of migrating neutrophils during the late phase was associated with urokinase-type plasminogen activator receptor (uPAR (show PLAUR Antibodies)), a regulator of beta2 integrin-dependent adherence and migration
analysis of structural divergence of GPI-80 in activated human neutrophils
This gene product is a member of the Vanin family of proteins that share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. The encoded protein is a GPI-anchored cell surface molecule that plays a role in transendothelial migration of neutrophils. This gene lies in close proximity to, and in same transcriptional orientation as two other vanin genes on chromosome 6q23-q24. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
, vanin 2
, vanin 3
, vascular non-inflammatory molecule 2-like
, Vannin 2
, glycosylphosphatidyl inositol-anchored protein GPI-80
, vascular non-inflammatory molecule 2