anti-Vitamin K Epoxide Reductase Complex, Subunit 1 (VKORC1) Antibodies

Vitamin K is essential for blood clotting but must be enzymatically activated. Additionally we are shipping VKORC1 Kits (17) and VKORC1 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
VKORC1 79001 Q9BQB6
VKORC1 27973 Q9CRC0
VKORC1 309004 Q6TEK4
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Top anti-VKORC1 Antibodies at antibodies-online.com

Showing 10 out of 29 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB Rabbit Anti-VKORC1 Antibody Catalog Number: ARP63330_P050 Formalin Fixed Paraffin Embedded Tissue: Human heart Tissue Observed Staining: Cytoplasmic Primary Antibody Concentration: 1:100 Other Working Concentrations: N/A Secondary Antibody: Donkey anti-Rabbit-Cy3 Secondary Antibody Concentration: 1:200 Magnification: 20X Exposure Time: 0.5 - 2.0 sec WB Suggested Anti-VKORC1 Antibody Titration: 1.0 ug/ml Positive Control: Fetal Brain 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB VKORC1 Antibody (N-term) (ABIN652040) western blot analysis in NCI-H460 cell line lysates (35 µg/lane). This demonstrates the VKORC1 antibody detected the VKORC1 protein (arrow). VKORC1 Antibody (N-term) (ABIN652040) immunohistochemistry analysis in formalin fixed and paraffin embedded human hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10 to 11 Days
$335.50
Details
Bat Rabbit Un-conjugated IHC, WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Rabbit Un-conjugated EIA, IF, IHC (p), WB   0.1 mg Log in to see 8 to 11 Days
$474.10
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Immunocytochemistry/Immunofluorescence: VKORC1 Antibody  - Staining of human cell line MCF7 shows localization to endoplasmic reticulum. Antibody staining is shown in green. Immunohistochemistry-Paraffin: VKORC1 Antibody  - Staining of human stomach, upper shows strong cytoplasmic positivity in glandular cells. 0.1 mL Log in to see 10 to 13 Days
$491.63
Details
Human Rabbit Un-conjugated ELISA, IHC, WB Immunohistochemical analysis of VKORC1 in human lung tissue with VKORC1 polyclonal antibody  at 2.5 ug/mL. Western blot analysis of VKORC1 in A-549 cell lysate with VKORC1 polyclonal antibody  at 1 ug/mL. 100 μg Log in to see 11 to 12 Days
$355.73
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of VKORC1 in A549 cell lysate with VKORC1 antibody at 1 µg/mL. 0.1 mg Log in to see 2 to 3 Days
$350.00
Details
Human Rabbit Un-conjugated IHC, WB   100 μg Log in to see 7 to 9 Days
$551.83
Details
Human Rabbit Un-conjugated IHC (p) Immunohistochemical staining of human stomach with VKORC1 polyclonal antibody  shows strong cytoplasmic positivity in glandular cells. 100 μL Log in to see 11 to 12 Days
$460.00
Details
Human Rabbit Un-conjugated IHC, ELISA, WB   200 μL Log in to see 11 to 16 Days
$594.00
Details

More Antibodies against VKORC1 Interaction Partners

Human Vitamin K Epoxide Reductase Complex, Subunit 1 (VKORC1) interaction partners

  1. VKORC1-1639A variant allele influenced warfarin daily maintenance dosage among our small, likely admixed Black patient population.

  2. Polymorphism in the promoter region of VKORC1 is effective in warfarin medication.

  3. The plasma S-warfarin (Cp(S)) time courses following the genotype-based dosing algorithms simulated using the PPK (show GJB2 Antibodies) estimates showed African Americans with CYP2C9 (show CYP2C9 Antibodies)*1/*1 and any of the VKORC1 genotypes would have an average Cp(S) at steady state 1.5-1.8 times higher than in Asians and whites.

  4. The final regression models for White and Black patients (Fig. 1) included age, weight, prosthetic valves, amiodarone use, CYP2C9 (show CYP2C9 Antibodies)*3, and VKORC1 3673 G>A genotypes as covariates, whereas possession of CYP2C9 (show CYP2C9 Antibodies)*2 and simvastatin use were retained in the final model for White, but not Black patients.

  5. No relationship between VKORC1 variants and clinical outcomes in elderly patients treated with vitamin K antagonists.

  6. Until the age of 19, weight has a far greater effect on Vitamin K antagonist dosing variation than VKORC1 and CYP2C9 (show CYP2C9 Antibodies) polymorphisms. During the age of 20-40years, VKORC1 and CYP2C9 (show CYP2C9 Antibodies) polymorphisms play a significant role.

  7. The VKORC1: c.-1639 G>A polymorphism is associated with aneurysms of the ascending aorta.

  8. 1639G4A polymorphism of the vitamin K epoxide reductase complex subunit 1 gene (VKORC1) is likely to be a new risk factor of Retinal Vascular Occlusion.

  9. Studied the association of CYP2C9 (show CYP2C9 Antibodies)*2 (430C/T), *3 (1075A/C) and VKORC1 (-1639G/A) polymorphisms on warfarin dose requirements in patients post cardiac valve surgery. Found age and presence of CYP2C9 (show CYP2C9 Antibodies) *2 allele significantly affect the daily dosage of warfarin during initiation of warfarin therapy after cardiac valve replacement surgery.

  10. The expression of VKOR in benign prostate epithelial cells, along with the association between a functional VKOR SNP and prostate cancer risk, suggests a possible role for VKOR in mediating the effect of warfarin on prostate cancer risk.

Mouse (Murine) Vitamin K Epoxide Reductase Complex, Subunit 1 (VKORC1) interaction partners

  1. quantified mRNA levels for VKORC1, VKORC1L1 (show VKORC1L1 Antibodies), GGCX (show GGCX Antibodies), and NQO1 (show NQO1 Antibodies) and measured VKOR enzymatic activities in 29 different tissues

  2. OCN is gamma-carboxylated by the gamma-carboxylase (GGCX (show GGCX Antibodies)) on three glutamic acid residues, a cellular process requiring reduction of vitamin K by a second enzyme, VKORC1.

  3. The involvement of VKORC1L1 (show VKORC1L1 Antibodies) in VKOR activity partly explains the low susceptibility of some extrahepatic tissues to vitamin K antagonists.

  4. molecular cloning [VKORC1]

  5. The genetic basis for resistance to anticoagulants lies in mutations in Vkorc1.

  6. An analysis of novel mutations show that the VKORC1 gene is the main target for spontaneous mutations conferring warfarin resistance.

  7. Each VKORC1 T-allele present in patients from the Rotterdam anticoagulation therapy study is shown to decrease the required acenocoumarol dosage by 5.1 mg/week.

VKORC1 Antigen Profile

Protein Summary

Vitamin K is essential for blood clotting but must be enzymatically activated. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. The product of this gene encodes the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is the product of this gene that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarin resistance. Two pseudogenes have been identified on chromosome 1 and the X chromosome. Two alternatively spliced transcripts encoding different isoforms have been described.

Gene names and symbols associated with VKORC1

  • vitamin K epoxide reductase complex, subunit 1 (VKORC1) antibody
  • vitamin K epoxide reductase complex subunit 1 (vkorc1) antibody
  • vitamin K epoxide reductase complex, subunit 1 (vkorc1) antibody
  • vitamin K epoxide reductase complex subunit 1 (VKORC1) antibody
  • Vitamin-K epoxide reductase (Vkor) antibody
  • vitamin K epoxide reductase complex, subunit 1 (Vkorc1) antibody
  • BP1071 antibody
  • CG33544 antibody
  • D7Wsu86e antibody
  • Dmel\\CG33544 antibody
  • EDTP308 antibody
  • HDC06808 antibody
  • IMAGE3455200 antibody
  • MGC89620 antibody
  • MST134 antibody
  • MST576 antibody
  • VKCFD2 antibody
  • VKOR antibody
  • VKORC1 antibody

Protein level used designations for VKORC1

phylloquinone epoxide reductase , vitamin K1 epoxide reductase (warfarin-sensitive) , vitamin K epoxide reductase complex, subunit 1 , CG33544-PA , Vkor-PA , vitamin K dependent clotting factors deficiency 2 , vitamin K epoxide reductase complex subunit 1 , vitamin K1 2,3-epoxide reductase subunit 1 , Warfarin resistance

GENE ID SPECIES
404205 Gallus gallus
446034 Takifugu rubripes
448775 Xenopus (Silurana) tropicalis
479775 Canis lupus familiaris
3346188 Drosophila melanogaster
79001 Homo sapiens
27973 Mus musculus
309004 Rattus norvegicus
445422 Bos taurus
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