anti-Vitamin K Epoxide Reductase Complex, Subunit 1 (VKORC1) Antibodies

Vitamin K is essential for blood clotting but must be enzymatically activated. Additionally we are shipping VKORC1 Kits (17) and VKORC1 Proteins (4) and many more products for this protein.

Gene Name	GeneID	UniProt
VKORC1	79001	Q9BQB6
VKORC1	27973	Q9CRC0
VKORC1	309004	Q6TEK4

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Top anti-VKORC1 Antibodies at antibodies-online.com

Showing 10 out of 29 products:

Catalog No.	Reactivity	Host	Conjugate	Application	Quantity	Supplier	Delivery	Price	Details
ABIN2789450	Cow	Rabbit	Un-conjugated	IHC, WB	100 μL	Log in to see	2 to 3 Days	$289.00	Details
ABIN652040	Human	Rabbit	Un-conjugated	IHC (p), WB	400 μL	Log in to see	10 to 11 Days	$335.50	Details
ABIN1494985	Bat	Rabbit	Un-conjugated	IHC, WB	50 μg	Log in to see	7 to 9 Days	$551.83	Details
ABIN5556597	Human	Rabbit	Un-conjugated	EIA, IF, IHC (p), WB	0.1 mg	Log in to see	8 to 11 Days	$474.10	Details
ABIN1031658	Human	Rabbit	Un-conjugated	ELISA, WB	0.1 mg	Log in to see	2 to 3 Days	$350.00	Details
ABIN1105001	Human	Rabbit	Un-conjugated	IHC, WB	100 μg	Log in to see	7 to 9 Days	$551.83	Details
ABIN2385766	Human	Rabbit	Un-conjugated	IHC, ELISA, WB	200 μL	Log in to see	11 to 16 Days	$594.00	Details
ABIN1947957	Human	Rabbit	APC	IHC, ELISA, WB	200 μL	Log in to see	7 to 9 Days	$1,013.83	Details
ABIN1947958	Human	Rabbit	Biotin	IHC, ELISA, WB	200 μL	Log in to see	7 to 9 Days	$1,013.83	Details
ABIN1947959	Human	Rabbit	FITC	IHC, ELISA, WB	200 μL	Log in to see	7 to 9 Days	$1,013.83	Details

VKORC1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes	Applications	Conjugate
Human	,	, , , , ,
Mouse (Murine)		,
Rat (Rattus)		,

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More Antibodies against VKORC1 Interaction Partners

Human Vitamin K Epoxide Reductase Complex, Subunit 1 (VKORC1) interaction partners

The plasma S-warfarin (Cp(S)) time courses following the genotype-based dosing algorithms simulated using the PPK (show GJB2 Antibodies) estimates showed African Americans with CYP2C9 (show CYP2C9 Antibodies)*1/*1 and any of the VKORC1 genotypes would have an average Cp(S) at steady state 1.5-1.8 times higher than in Asians and whites.
The final regression models for White and Black patients (Fig. 1) included age, weight, prosthetic valves, amiodarone use, CYP2C9 (show CYP2C9 Antibodies)*3, and VKORC1 3673 G>A genotypes as covariates, whereas possession of CYP2C9 (show CYP2C9 Antibodies)*2 and simvastatin use were retained in the final model for White, but not Black patients.
No relationship between VKORC1 variants and clinical outcomes in elderly patients treated with vitamin K antagonists.
Until the age of 19, weight has a far greater effect on Vitamin K antagonist dosing variation than VKORC1 and CYP2C9 (show CYP2C9 Antibodies) polymorphisms. During the age of 20-40years, VKORC1 and CYP2C9 (show CYP2C9 Antibodies) polymorphisms play a significant role.
The VKORC1: c.-1639 G>A polymorphism is associated with aneurysms of the ascending aorta.
1639G4A polymorphism of the vitamin K epoxide reductase complex subunit 1 gene (VKORC1) is likely to be a new risk factor of Retinal Vascular Occlusion.
Studied the association of CYP2C9 (show CYP2C9 Antibodies)*2 (430C/T), *3 (1075A/C) and VKORC1 (-1639G/A) polymorphisms on warfarin dose requirements in patients post cardiac valve surgery. Found age and presence of CYP2C9 (show CYP2C9 Antibodies) *2 allele significantly affect the daily dosage of warfarin during initiation of warfarin therapy after cardiac valve replacement surgery.
The expression of VKOR in benign prostate epithelial cells, along with the association between a functional VKOR SNP and prostate cancer risk, suggests a possible role for VKOR in mediating the effect of warfarin on prostate cancer risk.
analysis of VKORC1 AA-CYP2C9 (show CYP2C9 Antibodies)*1*1 genotypes reveals dosing algorithms for vitamin K antagonists
VKORC1 genotype influenced the likelihood of INR (show INSR Antibodies) lability during warfarin maintenance in atrial fibrillation patients.

Mouse (Murine) Vitamin K Epoxide Reductase Complex, Subunit 1 (VKORC1) interaction partners

quantified mRNA levels for VKORC1, VKORC1L1 (show VKORC1L1 Antibodies), GGCX (show GGCX Antibodies), and NQO1 (show NQO1 Antibodies) and measured VKOR enzymatic activities in 29 different tissues
OCN is gamma-carboxylated by the gamma-carboxylase (GGCX (show GGCX Antibodies)) on three glutamic acid residues, a cellular process requiring reduction of vitamin K by a second enzyme, VKORC1.
The involvement of VKORC1L1 (show VKORC1L1 Antibodies) in VKOR activity partly explains the low susceptibility of some extrahepatic tissues to vitamin K antagonists.
molecular cloning [VKORC1]
The genetic basis for resistance to anticoagulants lies in mutations in Vkorc1.
An analysis of novel mutations show that the VKORC1 gene is the main target for spontaneous mutations conferring warfarin resistance.
Each VKORC1 T-allele present in patients from the Rotterdam anticoagulation therapy study is shown to decrease the required acenocoumarol dosage by 5.1 mg/week.

VKORC1 Antigen Profile

Protein Summary

Vitamin K is essential for blood clotting but must be enzymatically activated. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. The product of this gene encodes the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is the product of this gene that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarin resistance. Two pseudogenes have been identified on chromosome 1 and the X chromosome. Two alternatively spliced transcripts encoding different isoforms have been described.

Gene names and symbols associated with VKORC1

vitamin K epoxide reductase complex, subunit 1 (VKORC1) antibody
vitamin K epoxide reductase complex subunit 1 (vkorc1) antibody
vitamin K epoxide reductase complex, subunit 1 (vkorc1) antibody
vitamin K epoxide reductase complex subunit 1 (VKORC1) antibody
Vitamin-K epoxide reductase (Vkor) antibody
vitamin K epoxide reductase complex, subunit 1 (Vkorc1) antibody

BP1071 antibody
CG33544 antibody
D7Wsu86e antibody
Dmel\\CG33544 antibody
EDTP308 antibody
HDC06808 antibody
IMAGE3455200 antibody
MGC89620 antibody
MST134 antibody
MST576 antibody
VKCFD2 antibody
VKOR antibody
VKORC1 antibody

Protein level used designations for VKORC1

phylloquinone epoxide reductase , vitamin K1 epoxide reductase (warfarin-sensitive) , vitamin K epoxide reductase complex, subunit 1 , CG33544-PA , Vkor-PA , vitamin K dependent clotting factors deficiency 2 , vitamin K epoxide reductase complex subunit 1 , vitamin K1 2,3-epoxide reductase subunit 1 , Warfarin resistance

GENE ID	SPECIES
404205	Gallus gallus
446034	Takifugu rubripes
448775	Xenopus (Silurana) tropicalis
479775	Canis lupus familiaris
3346188	Drosophila melanogaster
79001	Homo sapiens
27973	Mus musculus
309004	Rattus norvegicus
445422	Bos taurus

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