Vitamin K-dependent protein C Proteins (PROC)

PROC encodes a vitamin K-dependent plasma glycoprotein. Additionally we are shipping PROC Antibodies (216) and PROC Kits (68) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PROC 25268 P31394
PROC 19123 P33587
PROC 5624 P04070
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Top PROC Proteins at antibodies-online.com

Showing 10 out of 37 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
Details
Escherichia coli (E. coli) Mouse His tag,GST tag 100 μg Log in to see 15 to 18 Days
$752.00
Details
Escherichia coli (E. coli) Rat His tag,GST tag 100 μg Log in to see 15 to 18 Days
$784.00
Details
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 18 Days
$800.00
Details
Human Cells Mouse His tag 10 μg Log in to see 14 to 16 Days
$250.80
Details
Human Cells Human His tag 10 μg Log in to see 14 to 16 Days
$250.80
Details
Human Cells Human His tag   50 μg Log in to see 4 Days
$600.88
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$814.00
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details

PROC Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus) ,
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Mouse (Murine) , ,
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Human , , , , ,
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More Proteins for Vitamin K-dependent protein C (PROC) Interaction Partners

Mouse (Murine) Vitamin K-dependent protein C (PROC) interaction partners

  1. Data show that activated protein C signals via protease activated receptors PAR2 (show F2RL1 Proteins)/PAR3 (show F2RL2 Proteins) to expand Treg cells, mitigating the disease in mice.

  2. insulin (show INS Proteins) and aPC (show APC Proteins) converge on a common spliced-X-box binding protein-1 (show XBP1 Proteins) (sXBP1) signaling pathway to maintain endoplasmic reticulum (ER) homeostasis.

  3. loss of the convertase furin (show FURIN Proteins) or PC5 (show PCSK5 Proteins)/6 in hepatocytes results in a approximately 30% decrease in APC (show APC Proteins) levels, with no significant contribution from PACE4. We conclude that prior convertase cleavage of protein C in hepatocytes is critical for its thrombin (show F2 Proteins) activation.

  4. APC (show APC Proteins) modifies pulmonary fibrosis by limiting thrombin (show F2 Proteins)-dependent macrophage recruitment.

  5. Small interfering RNA-mediated silencing of protein C in apolipoprotein E (show APOE Proteins)-deficient mice creates a condition that allows the occurrence of spontaneous atherothrombosis.

  6. These findings reveal a novel biological function and mechanism of the protein C pathway in which protein S and the aPC (show APC Proteins)-cleaved form of fV are cofactors for anti-inflammatory cell signaling by aPC (show APC Proteins) in the context of endotoxemia and infection

  7. activated PC-EPCR-PAR1 signaling promotes hematopoietic stem cell retention in bone marrow.

  8. impaired EPCR (show PROCR Proteins)/protein C-binding interactions not only result in procoagulant and proinflammatory effects, but also impact hematopoiesis

  9. SOD prevents thrombomodulin (show THBD Proteins) methionine oxidation, promotes protein C activation, and protects against arterial and venous thrombosis in mice.

  10. sPLA2 (show PLA2G2A Proteins)-V plays a thrombogenic role by impairing the ability of EPCR (show PROCR Proteins) to promote protein C activation.

Human Vitamin K-dependent protein C (PROC) interaction partners

  1. The fusion protein recapitulates the functional and structural properties of the thrombin (show F2 Proteins)-thrombomodulin (show THBD Proteins) complex, prolongs the clotting time by generating pharmacological quantities of activated protein C and effectively diagnoses protein C deficiency in human plasma.

  2. Polymorphisms of F2, PROC, PROZ, and F13A1 Genes are Associated With Recurrent Spontaneous Abortion in Chinese Han Women.

  3. Laboratory tests and direct sequencing of PROC and SERPINC1 (show SERPINC1 Proteins) were conducted for the patient and his family members. Coagulation tests revealed that the patient presented type I antithrombin (show SERPINC1 Proteins) deficiency combined with decreased protein C activity resulting from a small insertion mutation c.848_849insGATGT in SERPINC1 (show SERPINC1 Proteins) and a short deletion variant c.572_574delAGA in PROC.

  4. Using protein C-factor VII (show TH Proteins) chimera demonstrate that APC (show APC Proteins) light chain amino acid residues outside the EPCR (show PROCR Proteins)-binding site enable cytoprotective PAR1 (show MARK2 Proteins) signaling.

  5. We recently identified a venous thrombosis patient whose plasma level of protein C antigen is normal, but its anticoagulant activity is only 34 % of the normal level. Genetic analysis revealed that the proband and her younger brother carry a novel heterozygous mutation c.346G>A, p.Gly74Ser (G74S) in PROC.

  6. Developed functional protein S assays that measure both the activated protein C- and TFPI (show TFPI Proteins)-cofactor activities of protein S in plasma, which are hardly if at all affected by the FV Leiden mutation.

  7. Protein C seems inversely associated with mortality in patients with advanced prostate, lung and pancreatic cancer. Further research should validate protein C as a biomarker for mortality, and explore the effects of protein C on progression of cancer.

  8. Genetically higher protein C was associated with a lower risk of ischaemic heart disease.

  9. EPCR (show PROCR Proteins) occupancy recruits G-protein coupled receptor kinase 5 (show GRK5 Proteins), thereby inducing beta-arrestin-2 (show ARRB2 Proteins) biased PAR1 (show MARK2 Proteins) signaling by both APC (show APC Proteins) and thrombin (show F2 Proteins). In

  10. A novel mutation of A309V in PROC was determined in a family of two patients with late onset protein C deficiency

Cow (Bovine) Vitamin K-dependent protein C (PROC) interaction partners

  1. Activated protein c is a ghrelin (show GHRL Proteins) endopeptidase.

  2. Activated protein C(APC (show APC Proteins)) combined with protein S(PS) had significant antithrombotic effect. APC (show APC Proteins) combined with PS prolonged clotting time. Dependence on APC (show APC Proteins)-cofactor activity of PS for expression of anticoagulant activity by APC (show APC Proteins).

PROC Protein Profile

Protein Summary

This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.

Gene names and symbols associated with PROC

  • protein C (inactivator of coagulation factors Va and VIIIa), a (proca)
  • protein C, inactivator of coagulation factors Va and VIIIa (PROC)
  • protein C (inactivator of coagulation factors Va and VIIIa) (PROC)
  • protein C, inactivator of coagulation factors Va and VIIIa S homeolog (proc.S)
  • protein C, inactivator of coagulation factors Va and VIIIa (proc)
  • vitamin K-dependent protein C (CpipJ_CPIJ000393)
  • vitamin K-dependent protein C (CpipJ_CPIJ002754)
  • vitamin K-dependent protein C (CpipJ_CPIJ003717)
  • vitamin K-dependent protein C (CpipJ_CPIJ003718)
  • vitamin K-dependent protein C (CpipJ_CPIJ014440)
  • vitamin K-dependent protein C (CpipJ_CPIJ018032)
  • vitamin K-dependent protein C (CpipJ_CPIJ018737)
  • protein C, inactivator of coagulation factors Va and VIIIa (Proc)
  • protein C (Proc)
  • APC protein
  • MGC64425 protein
  • PC protein
  • PROC protein
  • PROC1 protein
  • si:ch1073-188c16.3 protein
  • THPH3 protein
  • THPH4 protein
  • zgc:63987 protein

Protein level used designations for PROC

protein C , procl , anticoagulant protein C , vitamin K-dependent protein C , protein C (inactivator of coagulation factors Va and VIIIa) , vitamin K-dependent protein C-like , autoprothrombin IIA , blood coagulation factor XIV , inactivator of coagulation factors Va, VIII , catalytic region , protein C (precursor of vitamin K-dependent serine protease)

GENE ID SPECIES
393327 Danio rerio
395085 Gallus gallus
459593 Pan troglodytes
100302329 Ovis aries
380116 Xenopus laevis
548476 Xenopus (Silurana) tropicalis
100231143 Taeniopygia guttata
100448857 Pongo abelii
6031231 Culex quinquefasciatus
6033948 Culex quinquefasciatus
6035053 Culex quinquefasciatus
6035054 Culex quinquefasciatus
6047546 Culex quinquefasciatus
6052150 Culex quinquefasciatus
6052641 Culex quinquefasciatus
25268 Rattus norvegicus
19123 Mus musculus
5624 Homo sapiens
281428 Bos taurus
101096161 Felis catus
476104 Canis lupus familiaris
100051306 Equus caballus
396954 Sus scrofa
100009223 Oryctolagus cuniculus
699077 Macaca mulatta
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