anti-Voltage-Dependent Anion Channel 1 (VDAC1) Antibodies

VDAC1 encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. Additionally we are shipping VDAC1 Kits (22) and VDAC1 Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
VDAC1 7416 P21796
VDAC1 83529 Q9Z2L0
VDAC1 22333 Q60932
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Top anti-VDAC1 Antibodies at antibodies-online.com

Showing 10 out of 234 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated ELISA, WB Western Blot of Rabbit anti-VDAC/Porin antibody. Lane 1: MW ladder. Lane 2: Mouse Heart WCL. Load: 10 µg per lane. Primary antibody: VDAC/Porin antibody at 1:1,000 for overnight at 4°C. Secondary antibody: Peroxidase rabbit secondary antibody  at 1:40,000 for 30 min at RT. Block: Blocking Buffer for Fluorescent Western Blotting  for 30 min at RT. Predicted/Observed size: 32 kDa, 32 kDa for VDAC/Porin. Other band(s): Not identified Western Blot of Rabbit anti-VDAC/Porin antibody. Marker: Opal Pre-stained ladder . Lane 1: HEK293 lysate . Lane 2: HeLa Lysate . Lane 3: MCF-7 Lysate . Lane 4: Jurkat Lysate . Lane 5: A431 Lysate . Lane 6: LNCaP Lysate . Lane 7: A-172 Lysate . Lane 8: NIH/3T3 Lysate . Load: 35 µg per lane. Primary antibody: VDAC/Porin antibody at 1:1,000 for overnight at 4°C. Secondary antibody: Peroxidase rabbit secondary antibody  at 1:30,000 for 60 min at RT. Blocking Buffer: 1% Casein-TTBS for 30 min at RT. Predicted/Observed size: 31 kDa for VDACPorin. 200 μg 5 to 7 Days
$517.50
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-VDAC Picoband antibody, IHC(P) IHC(P): Rat Cardiac Muscle Tissue Anti-VDAC Picoband antibody, IHC(P) IHC(P): Mouse Cardiac Muscle Tissue 100 μg 4 to 6 Days
$280.00
Details
Human Rabbit Un-conjugated ICC, IHC (fro), IHC (p), WB Anti-VDAC/Porin antibody, ICC ICC: NIH3T3 Cell 100 μg 4 to 6 Days
$280.00
Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-VDAC1 Antibody Titration:  1.25ug/ml  ELISA Titer:  1:312500  Positive Control:  HepG2 cell lysate VDAC1 is strongly supported by BioGPS gene expression data to be expressed in Human HepG2 cells Rabbit Anti-VDAC1 Antibody  Paraffin Embedded Tissue: Human Liver Cellular Data: Hepatocytes Antibody Concentration: 4.0-8.0 ug/ml Magnification: 400X 100 μL 2 to 3 Days
$249.00
Details
Cow Rabbit Un-conjugated IHC, WB Western blot analysis of VDAC/Porinwith 3T3 cell lysate. 100 μg 2 to 3 Days
$280.00
Details
Arabidopsis thaliana Rabbit Un-conjugated BN PAGE, IL, WB 50 μg 6 to 8 Days
$490.94
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti VDAC Polyclonal Antibody, Unconjugated (ABIN686872) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL 3 to 7 Days
$329.45
Details
Mouse Rabbit Un-conjugated IHC, WB Immunofluorescence analysis of HeLa cell using VDAC1 antibody. Blue: DAPI for nuclear staining. Western blot analysis of extracts of various cell lines, using VDAC1 antibody. 100 μL 13 to 14 Days
$393.25
Details
Human Rabbit Un-conjugated IF, IHC, WB Western blot analysis of extracts of various cell lines, using VDAC1 antibody. 100 μL 11 to 13 Days
$366.77
Details
Human Rabbit Un-conjugated ELISA, IHC, WB Western blot analysis of Hela whole cell lysates, using VDAC1  Antibody. The lane on the left is treated with the antigen-specific peptide. ABIN6276410 at 1/100 staining Mouse liver tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22¡ãC. An HRP conjugated goat anti-rabbit antibody was used as the secondary 100 μL 11 to 12 Days
$390.77
Details

Top referenced anti-VDAC1 Antibodies

  1. Arabidopsis thaliana Polyclonal VDAC1 Primary Antibody for BN PAGE, IL - ABIN3155731 : Ito, Batth, Petzold, Redding-Johanson, Mukhopadhyay, Verboom, Meyer, Millar, Heazlewood: Analysis of the Arabidopsis Cytosolic Proteome Highlights Subcellular Partitioning of Central Plant Metabolism. in Journal of proteome research 2010 (PubMed)
    Show all 10 Pubmed References

  2. Mammalian Monoclonal VDAC1 Primary Antibody for ISt, IHC - ABIN1305042 : Joshi, Zhang, Lin, Gusain, Harris, Tree, Yin, Wu, Sheng, Dempsey, Fabry, Chiu: Deletion of mitochondrial anchoring protects dysmyelinating shiverer: implications for progressive MS. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 (PubMed)
    Show all 4 Pubmed References

  3. Human Polyclonal VDAC1 Primary Antibody for IF (p), IHC (p) - ABIN686872 : Manczak, Reddy: Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease. in Human molecular genetics 2012 (PubMed)
    Show all 4 Pubmed References

  4. Human Polyclonal VDAC1 Primary Antibody for ELISA, WB - ABIN129654 : Bourekas, Slivka, Shah, Sunshine, Suarez: Intraarterial thrombolytic therapy within 3 hours of the onset of stroke. in Neurosurgery 2003 (PubMed)
    Show all 3 Pubmed References

  5. Bird (Avian) Polyclonal VDAC1 Primary Antibody for ELISA, IHC - ABIN152118 : Chen, Dzitoyeva, Manev: Effect of valproic acid on mitochondrial epigenetics. in European journal of pharmacology 2012 (PubMed)
    Show all 3 Pubmed References

  6. Cow (Bovine) Polyclonal VDAC1 Primary Antibody for IHC, WB - ABIN2776153 : Zheng, Shi, Tian, Jiang, Jin, Chen, Almasan, Tang, Chen: Essential role of the voltage-dependent anion channel (VDAC) in mitochondrial permeability transition pore opening and cytochrome c release induced by arsenic trioxide. in Oncogene 2004 (PubMed)
    Show all 4 Pubmed References

  7. Rat (Rattus) Polyclonal VDAC1 Primary Antibody for ELISA, WB - ABIN1574110 : Sayed, He, Yang, Lin, Abdellatif: Transcriptional regulation patterns revealed by high resolution chromatin immunoprecipitation during cardiac hypertrophy. in The Journal of biological chemistry 2013 (PubMed)
    Show all 2 Pubmed References

  8. Cow (Bovine) Polyclonal VDAC1 Primary Antibody for IHC, WB - ABIN223288 : Bortner, Scoltock, Sifre, Cidlowski: Osmotic stress resistance imparts acquired anti-apoptotic mechanisms in lymphocytes. in The Journal of biological chemistry 2012 (PubMed)
    Show all 2 Pubmed References

  9. Human Polyclonal VDAC1 Primary Antibody for ELISA, IHC - ABIN6265958 : Zhang, He, Li, Liu, Wang, Zheng, Li: Emodin targets mitochondrial cyclophilin D to induce apoptosis in HepG2 cells. in Biomedicine & pharmacotherapy 2018 (PubMed)
    Show all 2 Pubmed References

  10. Mouse (Murine) Polyclonal VDAC1 Primary Antibody for IHC, WB - ABIN3021131 : Chen, Liu, Liu, Chen, Li, Chao, Yang, Liu, Mao, Pi: MEF2D Mediates the Neuroprotective Effect of Methylene Blue Against Glutamate-Induced Oxidative Damage in HT22 Hippocampal Cells. in Molecular neurobiology 2018 (PubMed)

More Antibodies against VDAC1 Interaction Partners

Arabidopsis thaliana Voltage-Dependent Anion Channel 1 (VDAC1) interaction partners

  1. Abnormal ovules in the process of female gametogenesis were observed. Both mitochondrial transmembrane potential and ATP synthesis rate were obviously reduced in the mitochondria isolated from atvdac1 plants.

  2. Data indicate that both voltage-dependent anion channel 1 (AtVDAC1) and calcium sensor CBL1 regulate cold stress responses during seed germination and plant development.

  3. AtVDAC1 has a main function in mitochondria

  4. VDAC1 is not only necessary for normal growth but also important for disease resistance through regulation of hydrogen peroxide generation.

Human Voltage-Dependent Anion Channel 1 (VDAC1) interaction partners

  1. findings implied that because of its interactions with VDAC-1, the cryptic MBP84-104 peptide invoked reprogramming of the cellular energy metabolism that favored enhanced cellular activity, rather than apoptotic cell death.

  2. The inactivation of VDAC-1 function either by pharmacological means or siRNA lead to significant decrease of Mycobacterium avium survival.

  3. The focus of this review is the involvement of mitochondrial dysfunction in Alzheimer's disease, and specifically, the role of the voltage-dependent anion channel 1 (VDAC1), which has been linked to Alzheimer's disease pathogenesis. [review]

  4. VDAC1 allows Ca(2+) access to the MCU, facilitating transport of Ca(2+) to the matrix, and also from the IMS to the cytosol. Intra-mitochondrial Ca(2+) controls energy production and metabolism by modulating critical enzymes in the tricarboxylic acid (TCA) cycle and fatty acid oxidation.

  5. associate dysfunction in Fe-S cluster biogenesis with cleavage of VDAC1

  6. HK1 competes with SOD1 G93A mutant from familial amyotrophic lateral sclerosis cases for binding VDAC1.SOD1 G93A mutant from familial amyotrophic lateral sclerosis cases binds VDAC1 with high affinity.

  7. Study shows that silencing voltage-dependent anion channel 1 (VDAC1) expression using short interfering RNA-VDAC1 in 9 glioblastoma-related cell lines, including patient-derived cells, led to marked decreases in VDAC1 levels and cell growth.

  8. VDAC1 plays an important role in dengue virus infection.

  9. VDAC1 is a direct target of miR-320a in non-small cell lung cancer (NSCLC) cells, and miR-320a inhibits VDAC1 expression in NSCLC cells

  10. The results of this study shown VDAC1, the Potential Target of miR-320a, is Upregulated in Response to HIV-1 Tat.

  11. the present study indicated that VDAC1 may interact with HPV16 E7 to promote the malignant progression of HPV-related cervical cancer

  12. Porin expression was lower in patients with heart failure with preserved ejection fraction compared to controls.

  13. Studied voltage-dependent anion channel 1 (VDAC1) structure and oligomerization using an Escherichia coli cell-free protein synthesis system and bicelle crystallization.

  14. In this study, molecular dynamics simulations and single-channel experiments of VDAC-1 show agreement for the current-voltage relationships of an "open" channel and they also show several subconducting transient states that are more cation selective in the simulations. We observed voltage-dependent asymmetric distortions of the VDAC-1 barrel and the displacement of particular charged amino acids.

  15. VDAC1 was accumulated in the desmin highly stained area of muscle fibers of desminopathy patients.

  16. work raises the interesting possibility that cholesterol-mediated regulation of VDAC1 may be facilitated through a specific binding site at the functionally important Glu(73) residue.

  17. this study describes novel drug candidates with a defined mechanism of action that involves inhibition of VDAC1 oligomerization, apoptosis, and mitochondrial dysfunction. The compounds VBIT-3 and VBIT-4 offer a therapeutic strategy for treating different diseases associated with enhanced apoptosis and point to VDAC1 as a promising target for therapeutic intervention.

  18. Results from the simulations show that HK2 binding restricts the movement of the VDAC1 N-terminal helix. As a result, VDAC1 is kept in the open state most of the time and probably allows a constant supply of ATP to HK2 for glycolysis.

  19. The findings of this study suggest that inhibition of intracellular Ca(2+/-) overload could protect cells from damage and that VDAC1 plays a considerable role in Cr(VI)-induced liver injury.

  20. Our study suggested that miR-7 suppressed the expression of VDAC1 in hepatocellular carcinoma

Pig (Porcine) Voltage-Dependent Anion Channel 1 (VDAC1) interaction partners

  1. Data confirm the synthesis of VDAC1 and 2 subtypes in GV (germinal vesicle) and MII (meiosis II) stage porcine oocytes as well as their protein expression.

Cow (Bovine) Voltage-Dependent Anion Channel 1 (VDAC1) interaction partners

  1. Results describe the expression of voltage-dependent anion channel isoforms in rat, bovine, and chicken brain mitochondria, and suggest that the nature of hexokinase binding site is not determined by the expression of a single VDAC isoform.

  2. Suggest that VDAC1 participates in volume regulatory processes in spermatozoa.

Mouse (Murine) Voltage-Dependent Anion Channel 1 (VDAC1) interaction partners

  1. VDAC's role in control of MOM permeability and regulation of mitochondrial respiration and metabolism.

  2. The expression of Vdac1 and total ATP level was decreased in the hippocampus of scopolamine-induced amnesic mice. mitochondrial membrane potential, cristae organization, and morphology were disrupted leading to increased ROS generation and reduced SOD and catalase activity. Vdac1 silencing decreased ATP level and mitochondrial membrane potential leading to increase in degenerated neuronal cells in hippocampus.

  3. This study presents the structure of Vdac1-tethered bilayer lipid membranes determined using neutron reflectivity.

  4. These results suggest a critical role for VDAC1 in mitochondrial fragmentation and its potential therapeutic value against glutamate-mediated oxidative neurotoxicity.

  5. The VDAC1-based peptide R-Tf-D-LP4 has multiple effects on liver cancer cells.

  6. Data indicate a specific pH-dependent dimerization of murine voltage-dependent anion channel 1 (mVDAC1).

  7. Studied melatonin's role in microvascular ischemia/reperfusion injury; found melatonin plays a protective role in mitochondrial fission-VDAC1-HK2-mPTP-mitophagy axis signal pathway suppression.

  8. microcirculatory ischemia/reperfusion injury can be attributed to Mff-dependent mitochondrial fission via voltage-dependent anion channel 1/hexokinase 2-mediated mitochondrial permeability transition pore opening and mitochondrial reactive oxygen species/cardiolipin involved cyt-c release.

  9. This study demonstrated that Vdac1 was significantly downregulated in amnesic mice and showed interaction with other proteins in interaction network.

  10. In this study, molecular dynamics simulations and single-channel experiments of VDAC-1 show agreement for the current-voltage relationships of an "open" channel and they also show several subconducting transient states that are more cation selective in the simulations. We observed voltage-dependent asymmetric distortions of the VDAC-1 barrel and the displacement of particular charged amino acids.

  11. this study describes novel drug candidates with a defined mechanism of action that involves inhibition of VDAC1 oligomerization, apoptosis, and mitochondrial dysfunction. The compounds VBIT-3 and VBIT-4 offer a therapeutic strategy for treating different diseases associated with enhanced apoptosis and point to VDAC1 as a promising target for therapeutic intervention.

  12. In cornu ammonis 1 region astrocytes, increasing miR-29a decreased VDAC1 and improved cell survival, while knockdown of VDAC1 improved survival.

  13. VDAC1-interacting anion transport inhibitors inhibited apoptosis via direct interaction with VDAC1 to inhibit its oligomerization and subsequent Cyto c release and apoptosis.

  14. Reducing VDAC1 expression induces a non-apoptotic role for pro-apoptotic proteins in glioblastoma multiforme cancer cell differentiation.

  15. TSPO as a novel element in the regulation of mitochondrial quality control by autophagy, and demonstrate the importance for cell homeostasis of its expression ratio with voltage-dependent anion channel 1

  16. ATP flows through VDAC through multiple pathways, in agreement with our structural data and experimentally determined physiological rates.

  17. Reduced VDAC1 expression protects against Alzheimer's disease and synaptic deficiencies.

  18. Data suggest presence of unstructured C-terminal tubulin tail in VDAC pore decreases conductance and switches selectivity from anionic to cationic rendering ATP transport virtually impossible; involves stable salt bridge (K336-tubulin/D186-Vdac1).

  19. MAVS binds to voltage-dependent anion channel 1 (VDAC1) and induces apoptosis by caspase-3 activation, which is independent of its role in innate immunity.

  20. Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease.

Zebrafish Voltage-Dependent Anion Channel 1 (VDAC1) interaction partners

  1. we found that Bcl-wav controls intracellular Ca(2+) trafficking by acting on the mitochondrial voltage-dependent anion channel, and possibly on MCU, with direct consequences on actin microfilament dynamics and blastomere migration guidance.

VDAC1 Antigen Profile

Protein Summary

This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involved in transmembrane electron transport. Alternate splicing results in multiple transcript variants. Multiple pseudogenes of this gene are found on chromosomes 1, 2 3, 6, 9, 12, X and Y.

Gene names and symbols associated with VDAC1

  • voltage-dependent anion channel 1 S homeolog (vdac1.S) antibody
  • voltage-dependent anion channel 1 (vdac1) antibody
  • voltage dependent anion channel 1 (VDAC1) antibody
  • voltage-dependent anion channel 1 (Vdac1) antibody
  • voltage dependent anion channel 1 (Vdac1) antibody
  • 5076 antibody
  • AL033343 antibody
  • ARABIDOPSIS THALIANA VOLTAGE DEPENDENT ANION CHANNEL 1 antibody
  • ATVDAC1 antibody
  • fa13f11 antibody
  • PORIN antibody
  • T22N4.9 antibody
  • T22N4_9 antibody
  • VDAC-1 antibody
  • VDAC1 antibody
  • Vdac5 antibody
  • voltage dependent anion channel 1 antibody
  • wu:fa13f11 antibody
  • zgc:85830 antibody

Protein level used designations for VDAC1

voltage-dependent anion channel 1 , outer mitochondrial membrane protein porin 1 , plasmalemmal porin , porin 31HL , porin 31HM , voltage-dependent anion-selective channel protein 1 , VDAC-1 , rVDAC1 , BR1-VDAC , brain-derived voltage-dependent anion channel 1 , VDAC-5 , mVDAC1 , mVDAC5 , voltage-dependent anion-selective channel protein 5

GENE ID SPECIES
380376 Xenopus laevis
549246 Xenopus (Silurana) tropicalis
745717 Pan troglodytes
820914 Arabidopsis thaliana
7416 Homo sapiens
83529 Rattus norvegicus
397010 Sus scrofa
282119 Bos taurus
100008751 Oryctolagus cuniculus
22333 Mus musculus
334582 Danio rerio
474681 Canis lupus familiaris
100145866 Ovis aries
100723897 Cavia porcellus
416320 Gallus gallus
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