Voltage-Dependent Anion Channel 1 Proteins (VDAC1)

VDAC1 encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. Additionally we are shipping VDAC1 Antibodies (216) and VDAC1 Kits (24) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
VDAC1 7416 P21796
Rat VDAC1 VDAC1 83529 Q9Z2L0
Mouse VDAC1 VDAC1 22333 Q60932
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Top VDAC1 Proteins at antibodies-online.com

Showing 3 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Escherichia coli (E. coli) Human GST tag,His tag 100 μg Log in to see 15 to 18 Days

VDAC1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,

More Proteins for Voltage-Dependent Anion Channel 1 (VDAC1) Interaction Partners

Arabidopsis thaliana Voltage-Dependent Anion Channel 1 (VDAC1) interaction partners

  1. Abnormal ovules in the process of female gametogenesis were observed. Both mitochondrial transmembrane potential and ATP synthesis rate were obviously reduced in the mitochondria isolated from atvdac1 plants.

  2. Data indicate that both voltage-dependent anion channel 1 (AtVDAC1) and calcium sensor CBL1 regulate cold stress responses during seed germination and plant development.

  3. AtVDAC1 has a main function in mitochondria

  4. VDAC1 is not only necessary for normal growth but also important for disease resistance through regulation of hydrogen peroxide generation.

Human Voltage-Dependent Anion Channel 1 (VDAC1) interaction partners

  1. VDAC1 allows Ca(2+) access to the MCU, facilitating transport of Ca(2+) to the matrix, and also from the IMS to the cytosol. Intra-mitochondrial Ca(2+) controls energy production and metabolism by modulating critical enzymes in the tricarboxylic acid (TCA) cycle and fatty acid oxidation.

  2. associate dysfunction in Fe-S cluster biogenesis with cleavage of VDAC1

  3. HK1 competes with SOD1 G93A mutant from familial amyotrophic lateral sclerosis cases for binding VDAC1.SOD1 G93A mutant from familial amyotrophic lateral sclerosis cases binds VDAC1 with high affinity.

  4. Study shows that silencing voltage-dependent anion channel 1 (VDAC1) expression using short interfering RNA-VDAC1 in 9 glioblastoma-related cell lines, including patient-derived cells, led to marked decreases in VDAC1 levels and cell growth.

  5. VDAC1 plays an important role in dengue virus infection.

  6. VDAC1 is a direct target of miR-320a in non-small cell lung cancer (NSCLC) cells, and miR-320a inhibits VDAC1 expression in NSCLC cells

  7. The results of this study shown VDAC1, the Potential Target of miR-320a, is Upregulated in Response to HIV-1 Tat.

  8. the present study indicated that VDAC1 may interact with HPV16 E7 to promote the malignant progression of HPV-related cervical cancer

  9. Porin expression was lower in patients with heart failure with preserved ejection fraction compared to controls.

  10. Studied voltage-dependent anion channel 1 (VDAC1) structure and oligomerization using an Escherichia coli cell-free protein synthesis system and bicelle crystallization.

  11. In this study, molecular dynamics simulations and single-channel experiments of VDAC-1 show agreement for the current-voltage relationships of an "open" channel and they also show several subconducting transient states that are more cation selective in the simulations. We observed voltage-dependent asymmetric distortions of the VDAC-1 barrel and the displacement of particular charged amino acids.

  12. VDAC1 was accumulated in the desmin highly stained area of muscle fibers of desminopathy patients.

  13. work raises the interesting possibility that cholesterol-mediated regulation of VDAC1 may be facilitated through a specific binding site at the functionally important Glu(73) residue.

  14. this study describes novel drug candidates with a defined mechanism of action that involves inhibition of VDAC1 oligomerization, apoptosis, and mitochondrial dysfunction. The compounds VBIT-3 and VBIT-4 offer a therapeutic strategy for treating different diseases associated with enhanced apoptosis and point to VDAC1 as a promising target for therapeutic intervention.

  15. Results from the simulations show that HK2 binding restricts the movement of the VDAC1 N-terminal helix. As a result, VDAC1 is kept in the open state most of the time and probably allows a constant supply of ATP to HK2 for glycolysis.

  16. The findings of this study suggest that inhibition of intracellular Ca(2+/-) overload could protect cells from damage and that VDAC1 plays a considerable role in Cr(VI)-induced liver injury.

  17. Our study suggested that miR-7 suppressed the expression of VDAC1 in hepatocellular carcinoma

  18. Results shows that beta-barrel of human VDAC1 embedded into a membrane is highly flexible and that Ca2+, a key regulator of metabolism and apoptosis, strongly decreases its plasticity suggesting that physiological VDAC function depends on the molecular plasticity of its channel.

  19. High VDAC1 expression is associated with cervical cancer.

  20. Studies using B16F10 and A375 cells genetically modified for ATF2 indicated that mitochondrial ATF2 was able to dissociate Bim from the Mcl-1/Bim complex to trigger VDAC1 oligomerization.

Pig (Porcine) Voltage-Dependent Anion Channel 1 (VDAC1) interaction partners

  1. Data confirm the synthesis of VDAC1 and 2 subtypes in GV (germinal vesicle) and MII (meiosis II) stage porcine oocytes as well as their protein expression.

Cow (Bovine) Voltage-Dependent Anion Channel 1 (VDAC1) interaction partners

  1. Results describe the expression of voltage-dependent anion channel isoforms in rat, bovine, and chicken brain mitochondria, and suggest that the nature of hexokinase binding site is not determined by the expression of a single VDAC isoform.

  2. Suggest that VDAC1 participates in volume regulatory processes in spermatozoa.

Zebrafish Voltage-Dependent Anion Channel 1 (VDAC1) interaction partners

  1. we found that Bcl-wav controls intracellular Ca(2+) trafficking by acting on the mitochondrial voltage-dependent anion channel, and possibly on MCU, with direct consequences on actin microfilament dynamics and blastomere migration guidance.

VDAC1 Protein Profile

Protein Summary

This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involved in transmembrane electron transport. Alternate splicing results in multiple transcript variants. Multiple pseudogenes of this gene are found on chromosomes 1, 2 3, 6, 9, 12, X and Y.

Gene names and symbols associated with VDAC1

  • voltage-dependent anion channel 1 S homeolog (vdac1.S)
  • voltage-dependent anion channel 1 (vdac1)
  • voltage dependent anion channel 1 (VDAC1)
  • voltage-dependent anion channel 1 (Vdac1)
  • voltage dependent anion channel 1 (Vdac1)
  • 5076 protein
  • AL033343 protein
  • ATVDAC1 protein
  • fa13f11 protein
  • PORIN protein
  • T22N4.9 protein
  • T22N4_9 protein
  • VDAC-1 protein
  • VDAC1 protein
  • Vdac5 protein
  • voltage dependent anion channel 1 protein
  • wu:fa13f11 protein
  • zgc:85830 protein

Protein level used designations for VDAC1

voltage-dependent anion channel 1 , outer mitochondrial membrane protein porin 1 , plasmalemmal porin , porin 31HL , porin 31HM , voltage-dependent anion-selective channel protein 1 , VDAC-1 , rVDAC1 , BR1-VDAC , brain-derived voltage-dependent anion channel 1 , VDAC-5 , mVDAC1 , mVDAC5 , voltage-dependent anion-selective channel protein 5

380376 Xenopus laevis
549246 Xenopus (Silurana) tropicalis
745717 Pan troglodytes
820914 Arabidopsis thaliana
7416 Homo sapiens
83529 Rattus norvegicus
397010 Sus scrofa
282119 Bos taurus
100008751 Oryctolagus cuniculus
22333 Mus musculus
334582 Danio rerio
474681 Canis lupus familiaris
100145866 Ovis aries
100723897 Cavia porcellus
416320 Gallus gallus
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