Von Willebrand Factor Proteins (VWF)

The glycoprotein encoded by VWF functions as both an antihemophilic factor carrier and a platelet-vessel wall mediator in the blood coagulation system.

list all proteins Gene Name GeneID UniProt
Human VWF VWF 7450 P04275
Rat VWF VWF 116669  
Mouse VWF VWF 22371 Q8CIZ8
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Top VWF Proteins at antibodies-online.com

Showing 10 out of 23 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
CHO Cells Human His tag 100 μg Log in to see 20 to 21 Days
$382.80
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$12,127.90
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Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 18 Days
$688.00
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Escherichia coli (E. coli) Wild boar His tag 100 μg Log in to see 15 to 18 Days
$784.00
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Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 15 to 18 Days
$608.00
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Insect cells (Sf9) Human DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$504.90
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Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 15 to 18 Days
$560.00
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Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,201.00
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Escherichia coli (E. coli) Human His-SUMO Tag   50 μg Log in to see 11 Days
$341.00
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Escherichia coli (E. coli) Dog GST tag,His tag 100 μg Log in to see 15 to 18 Days
$797.00
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More Proteins for Von Willebrand Factor (VWF) Interaction Partners

Human Von Willebrand Factor (VWF) interaction partners

  1. von Willebrand Factor is steadily elevated throughout the course of dysrhythmia in NVAF patients treated with warfarin and in those with higher intensity of left atrium blood stasis.

  2. The levels of VWF-cleaving protease ADAMTS13 (show ADAMTS13 Proteins) among neonates were higher as compared with healthy adults, despite a significant elevation of VWF antigen (Ag) and Ristocetin cofactor (RiCof) noted in all neonates.

  3. The pathogenic effects of candidate VWF gene mutations were explored in this study. Molecular dynamic simulations on p.M771I mutant VWF revealed distinct structural rearrangements including a large deviation in the E' domain, and significant loss of beta-sheet secondary structure.

  4. investigated the roles of ADAMTS13 (show ADAMTS13 Proteins) and VWF in thrombotic events of patients with Connective Tissue Diseases

  5. vWF had a significant prognostic impact on cardiovascular mortality when OPG (show TNFRSF11B Proteins) levels were low. Low levels of both OPG (show TNFRSF11B Proteins) and act vWF were associated with a 99 % survival rate during the follow-up of five years.

  6. Studied the significance of the von Willebrand factor (VWF)/ ADAMTS-13 (show ADAMTS13 Proteins) ratio in advanced non-small-cell lung cancer (NSCLC). Findings suggest that the imbalance between VWF secretion and ADAMTS-13 (show ADAMTS13 Proteins) may play a role in the hypercoagulability state in advanced NSCLC, and increase of the plasma VWF/ADAMTS-13 (show ADAMTS13 Proteins) ratio may serve as an independent predictive factor for mortality in patients with advanced NSCLC.

  7. Type 3 von Willebrand disease patients with the Pro2808Leufs*24 have bioavailable platelet-derived VWF that may produce a milder bleeding phenotype than other type 3s

  8. vaso-occlusive crisis in sickle cell disease is associated with increased reactivity of VWF, without a pronounced ADAMTS-13 (show ADAMTS13 Proteins) deficiency

  9. Different patterns of VWF multimer loss were seen in heart failure patients treated with implantation of left ventricular assist device and total artificial heart, which may contribute to bleeding patterns.

  10. Complex VWF-ADAMTS13 (show ADAMTS13 Proteins)-mediated mechanisms disturb haemostasis in inflammatory bowel disease.

Pig (Porcine) Von Willebrand Factor (VWF) interaction partners

  1. In conclusion, endothelial vWF knockdown prevented angiotensin II-induced ET-1 (show EDN1 Proteins) upregulation through attenuation of NOX-mediated O2- production.

  2. alterations in glycosylation of vWF and other adhesion proteins associated with the targeting of the alpha1,3-Gal (show GAL Proteins)-epitope in mutant swine may have salutatory effects on the primate platelet activation observed in these xenografts.

Cow (Bovine) Von Willebrand Factor (VWF) interaction partners

  1. Hemodynamic activation of vWF and increased plasma ADAMTS-13 (show ADAMTS13 Proteins) may have contributed to reduced high-molecular-weight vWF multimers and impairment of the vWF-platelet aggregation pathway during mechanical circulatory support.

  2. both the gpIb-VWF interaction and the integrin alpha(2 (show ITGA2 Proteins))beta(1)-collagen interaction contribute to platelet adhesion under high shear stress; integrin alpha(II (show GSTA3 Proteins))beta(1) makes a greater contribution to adhesion to type I collagen because less VWF is bound

Mouse (Murine) Von Willebrand Factor (VWF) interaction partners

  1. this study shows that Von Willebrand factor protects against acute CCl4 (show CCL4 Proteins)-induced hepatotoxicity through phospho-p38 MAPK (show MAPK14 Proteins) signaling pathway inhibition

  2. the ADAMTS13 (show ADAMTS13 Proteins)-vWF axis is partially involved in the pathophysiology of kidney ischemic reperfusion injury.

  3. Type 2N von Willebrand disease variants were associated with decreased VWF secretion and impaired factor VIII binding/stability.

  4. identify a critical role for VWF in cerebral inflammation and blood-brain barrier damage after intracerebral haemorrhage

  5. The low-molecular-weight heparin (LMWH) Tinzaparin inhibited Von Willebrand factor (VWF) fiber formation and vessel occlusion in tumor vessels by blocking thrombin (show F2 Proteins)-induced endothelial cells (ECs) activation and vascular endothelial growth factor-A (VEGF-A (show VEGFA Proteins))-mediated VWF release.

  6. In a laser injury-induced thrombosis model, P-selectin (show SELP Proteins) modulates thrombus propagation independently of VWF and TSP1 (show GZMA Proteins)

  7. Refrigeration-induced binding of VWF to platelets facilitates their rapid clearance by inducing GPIbalpha (show GP1BA Proteins)-mediated signaling.

  8. BLOC-2 (show HPS6 Proteins) subunit HPS6 (show HPS6 Proteins) deficiency affects the tubulation and secretion of von Willebrand factor from mouse endothelial cells

  9. A novel single-domain antibody against von Willebrand factor A1 domain that interferes with VWF-platelet interactions in vivo. By using this sdAb, show that the A1 domain is pertinent to the participation of VWF in the inflammatory response.

  10. These experiments delineate an unexpected pathway in which microbiota-triggered TLR2 signaling alters the synthesis of proadhesive VWF by the liver endothelium and favors platelet integrin-dependent thrombus growth.

VWF Protein Profile

Protein Summary

The glycoprotein encoded by this gene functions as both an antihemophilic factor carrier and a platelet-vessel wall mediator in the blood coagulation system. It is crucial to the hemostasis process. Mutations in this gene or deficiencies in this protein result in von Willebrand's disease. An unprocessed pseudogene has been found on chromosome 22.

Gene names and symbols associated with Von Willebrand Factor Proteins (VWF)

  • von Willebrand factor (VWF)
  • von Willebrand factor (vwf)
  • von Willebrand factor (Vwf)
  • Von Willebrand factor (Vwf)
  • 6820430P06Rik protein
  • AI551257 protein
  • B130011O06Rik protein
  • C630030D09 protein
  • F8VWF protein
  • si:ch1073-474e24.1 protein
  • VWD protein
  • VWF protein

Protein level used designations for Von Willebrand Factor Proteins (VWF)

von Willebrand factor , coagulation factor VIII VWF

GENE ID SPECIES
451773 Pan troglodytes
493760 Felis catus
570643 Danio rerio
619381 Monodelphis domestica
722019 Macaca mulatta
7450 Homo sapiens
116669 Rattus norvegicus
399544 Canis lupus familiaris
100009165 Oryctolagus cuniculus
399543 Sus scrofa
280958 Bos taurus
100732530 Cavia porcellus
419031 Gallus gallus
101110931 Ovis aries
22371 Mus musculus
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