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The glycoprotein encoded by VWF functions as both an antihemophilic factor carrier and a platelet-vessel wall mediator in the blood coagulation system. Additionally we are shipping VWF Antibodies (519) and VWF Kits (104) and many more products for this protein.
Showing 10 out of 21 products:
VWF binding to MMRN1 (show MMRN1 Proteins) was enhanced by shear exposure and ristocetin, and required VWF A1A2A3 region, specifically the A1 and A3 domains.
coronary thrombi in STEMI patients resistant to fibrinolysis are characterised by higher fibrin, P-selectin (show SELP Proteins) and VWF content than lysis-sensitive thrombi
We compared the classical Sanger sequencing approach and NGS to assess the value-added effect on the analysis of the mutation distribution in different types of VWD. Sixty-two different VWF mutations were identified, 27 of which had not been previously described. NGS detected 26 additional mutations, contributing to a broad overview of the mutant alleles present in each VWD type.
These observations support the hypothesis that a significantly reduced ADAMTS13 (show ADAMTS13 Proteins)/VWF ratio in the coronary artery flow plays a pathogenic role in acute coronary syndromes (ACS (show PLA2G15 Proteins)) and suggest that transition from laminar to turbulent flow at sites of coronary stenosis further enhances VWF activation and deposition.
the major genetic factors affecting plasma VWF levels, i.e. variants at ABO (show ABO Proteins), VWF and a locus on chromosome 2, operate primarily through their effects on VWF clearance
The unique phenotype of VWD2 type IIC-Miami results from dominant impairment of multimer assembly, an aberrant structure of mutant mature VWF and reduced clearance in vivo
Low ADAMTS-13 (show ADAMTS13 Proteins) activity is associated with an increased risk of coronary heart disease in the elderly, independently of VWF and established cardiovascular risk factors
Very low birth weight preterm neonates have increased numbers of platelets interacting with von Willebrand Factor, and increased GPIbalpha (show GP1BA Proteins) expression on the platelet surface
N-linked glycan truncation causes enhanced clearance of plasma-derived von Willebrand factor; variation in VWF glycosylation may be important in the pathophysiology underlying type 1C VWD
Data suggest that an aspartate at position 1261 is the most critical residue of VWF N-terminal linker for inhibiting binding of VWF A1 domain to GP1BA (show GP1BA Proteins) on platelets in a model simulating blood flow velocity; network of salt bridges between Asp1261 and rest of VWF A1 domain lock N-terminal linker in place such that binding to GP1BA (show GP1BA Proteins) is reduced.
alterations in glycosylation of vWF and other adhesion proteins associated with the targeting of the alpha1,3-Gal (show GAL Proteins)-epitope in mutant swine may have salutatory effects on the primate platelet activation observed in these xenografts.
Hemodynamic activation of vWF and increased plasma ADAMTS-13 (show ADAMTS13 Proteins) may have contributed to reduced high-molecular-weight vWF multimers and impairment of the vWF-platelet aggregation pathway during mechanical circulatory support.
both the gpIb-VWF interaction and the integrin alpha(2 (show ITGA2 Proteins))beta(1)-collagen interaction contribute to platelet adhesion under high shear stress; integrin alpha(II (show GSTA3 Proteins))beta(1) makes a greater contribution to adhesion to type I collagen because less VWF is bound
Refrigeration-induced binding of VWF to platelets facilitates their rapid clearance by inducing GPIbalpha (show GP1BA Proteins)-mediated signaling.
BLOC-2 (show HPS6 Proteins) subunit HPS6 (show HPS6 Proteins) deficiency affects the tubulation and secretion of von Willebrand factor from mouse endothelial cells
A novel single-domain antibody against von Willebrand factor A1 domain that interferes with VWF-platelet interactions in vivo. By using this sdAb, show that the A1 domain is pertinent to the participation of VWF in the inflammatory response.
These experiments delineate an unexpected pathway in which microbiota-triggered TLR2 signaling alters the synthesis of proadhesive VWF by the liver endothelium and favors platelet integrin-dependent thrombus growth.
ADAMTS13 (show ADAMTS13 Proteins) controls vascular remodeling by modifying VWF reactivity during stroke recovery.
these novel findings support the hypothesis that conformation of the VWF A domains plays a critical role in modulating macrophage-mediated clearance of VWF in vivo.
results revealed localized vascular expression of FVIII (show F8 Proteins) and von Willebrand factor and identified lymphatic endothelial cell as a major cellular source of FVIII (show F8 Proteins) in extrahepatic tissues.
Endothelial cell derivedVWF is the major determinant that mediates VWF-dependent ischemic stroke by promoting postischemic thrombo-inflammation.
VWF deficiency reduces the progression of liver fibrosis, suggesting a mechanistic role of elevated plasma VWF levels in cirrhosis
von Willebrand factor exerts beneficial effects in a mouse sepsis model via recruitment of neutrophils to inflammatory sites.
The glycoprotein encoded by this gene functions as both an antihemophilic factor carrier and a platelet-vessel wall mediator in the blood coagulation system. It is crucial to the hemostasis process. Mutations in this gene or deficiencies in this protein result in von Willebrand's disease. An unprocessed pseudogene has been found on chromosome 22.
von Willebrand factor
, coagulation factor VIII VWF