Von Willebrand Factor A Domain Containing 1 Proteins (VWA1)

Human Von Willebrand Factor A Domain Containing 1 (VWA1) interaction partners

1. The VWA1 domain of matrilin-3 (show MATN3 Proteins) is primarily responsible for the induction of IL-6 (show IL6 Proteins) release from primary human chondrocytes.

2. WARP is ideally placed to function as an adapter protein (show TOLLIP Proteins) in the cartilage pericellular matrix.

3. The distinct localization of WARP in the human and mouse inner ear blood vessels suggests an important role maintaining the integrity of the vasculature.

4. Evolutionary relationship between von Willebrand factor A domain-related protein (WARP), and the fibril-associated collagen with interrupted triple helix (FACIT) and FACIT-like subfamilies of collagens.

5. WARP forms macromolecular structures that interact with perlecan (show HSPG2 Proteins) to contribute to the assembly and/or maintenance of "permanent" cartilage structures during development and in mature cartilages

6. Urea was used as a surrogate for shear to study denaturation of the individual VWF (show VWF Proteins) recombinant A domains, A1, A2, and A3, and the domain triplet, A1-A2-A3.

Mouse (Murine) Von Willebrand Factor A Domain Containing 1 (VWA1) interaction partners

1. evolutionary relationship between von Willebrand factor A-domain-related protein (WARP), and the fibril-associated collagen with interrupted triple helix (FACIT) and FACIT-like subfamilies of collagens

2. WARP forms macromolecular structures that interact with perlecan (show HSPG2 Proteins) to contribute to the assembly and/or maintenance of "permanent" cartilage structures during development and in mature cartilages

3. identification of WARP as a component of a limited range of specialized basement membranes provides further evidence for the heterogeneous composition of basement membranes between different tissues

4. although WARP is not essential for basement membrane formation or musculoskeletal development, it has critical roles in the structure and function of peripheral nerves.