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WFDC5 encodes a member of the WAP-type four-disulfide core (WFDC) domain family.
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analysis of promoter of mutated human whey acidic protein (WAP) gene
C-terminal domain of the nuclear factor I-B2 isoform is glycosylated and transactivates the WAP gene in tumor cells
This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. Most WFDC proteins contain only one WFDC domain, and this encoded protein contains two WFDC domains. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster.
WAP four-disulfide core domain 5
, WAP four-disulfide core domain protein 5
, p53-responsive gene 5 protein
, protease inhibitor WAP1
, putative protease inhibitor WAP1