WBP2 N-terminal Like Proteins (WBP2NL)

Xenopus laevis WBP2 N-terminal Like (WBP2NL) interaction partners

1. wbp2nl has an additional developmental role in regionalizing the embryonic ectoderm.

2. Data provides evidence for the first time that sperm-anchored PAWP is a primary initiator of zygotic development.

Human WBP2 N-terminal Like (WBP2NL) interaction partners

1. PLCzeta and PAWP impairments may be one of the possible etiologies of decreased fertility in Oligoasthenoteratozoospermia

2. The value of PAWP and PLCzeta as indicators of sperm quality was studied.

3. Taken into account that WBP2NL/PAWP gene and protein levels and distribution did not correlate with fertilization rates, this study questions the interest of WBP2NL/PAWP protein and gene expression analysis in sperm cells as a prognostic factor for the outcome of ICSI cycles

4. High fertilization (56.06%) and pregnancy (41.7%) rates accomplished in this study following ICSI-AOA indicated that expression profiles of PLCzeta, PAWP, and TR-KIT were low in globozoospermic individuals

5. In male infertility, the absence of PLCZ1 alone is sufficient to prevent oocyte activation irrespective of the presence of PAWP.

6. Conclude that human PAWP is neither sufficient nor necessary for the Ca(2+) oscillations that initiate mammalian oocyte activation at fertilization.

7. WBP2NL might play roles as an anti-apoptotic factor or co-activator to promote breast cancer cell survival and proliferation.

8. Data suggest that PAWP (WW domain-binding protein 2-like) from sperm (rather than PLCZ [phospholipase C zeta] from sperm) acts as the 'sperm factor' within the egg at fertilization and is involved in 'egg activation' and embryogenesis. [REVIEW]

9. Demonstrate significant correlations between sperm PAWP levels and both fertilization rates and normal embryonic development after intracytoplasmic sperm injection.

Cow (Bovine) WBP2 N-terminal Like (WBP2NL) interaction partners

1. PAWP correlates with semen/fertility parameters used in the cattle artificial insemination industry, making PAWP a potential biomarker of bull fertility.

2. PAWP is a sperm-specific WW domain-binding protein that promotes meiotic resumption and pronuclear development during fertilization

Mouse (Murine) WBP2 N-terminal Like (WBP2NL) interaction partners

1. PAWP does not play an essential role in mouse fertilization

2. The data suggest that sperm-derived PAWP is not involved in triggering Ca(2+) oscillations at fertilization in mammalian oocytes.

3. These results indicate that PAWP plays a role in spermatogenesis and germ cell development. Moreover, we suggest PAWP as one of the markers that could be looked in ESC studies as a confirmed testis-specific gene

4. The postacrosomal assembly of sperm head protein, PAWP, is independent of acrosome formation and dependent on microtubular manchette transport