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WDR12 encodes a member of the WD repeat protein family.
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MI associated WDR12 allele was associated significantly with diastolic dysfunction and left atrial size.
The DDX27 (show DDX27 Antibodies) can interact specifically with the Pes1 (show PES1 Antibodies) and Bop1 (show BOP1 Antibodies) but fulfils critical function(s) for proper 3' end formation of 47S rRNA independently of the PeBoW-complex.
WDR12 triggers accumulation of p53 in a p19ARF-independent manner in proliferating cells but not in quiescent cells.
Results describe the role of PeBoW-specific proteins Pes1 (show PES1 Antibodies), Bop1 (show BOP1 Antibodies), and WDR12 in complex assembly and stability, nucleolar transport, and pre-ribosome association.
Amino-terminal similarity to Notchless WD repeat protein (show DCAF7 Antibodies). May function in the modulation of Notch (show NOTCH1 Antibodies) signaling activity.
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein is highly similar to the mouse WD repeat domain 12 protein at the amino acid level. The protein encoded by this gene is a component of a nucleolar protein complex that affects maturation of the large ribosomal subunit.
WD repeat domain 12
, WD repeat-containing protein 12
, ribosome biogenesis protein WDR12
, WD repeat domain 12 protein
, nuclear protein Ytm1
, ribosome biogenesis protein wdr12