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WDR20 encodes a WD repeat-containing protein that functions to preserve and regulate the activity of the USP12-UAF1 deubiquitinating enzyme complex. Additionally we are shipping WD Repeat Domain 20 Antibodies (37) and and many more products for this protein.
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Results identified WDR20 as an important adaptor protein involved in ERAD system by promoting protein ubiquitination.
UAF1 and WDR20 interact with USP12 at two distinct sites far from its catalytic center, allosterically activating the enzyme.
our data suggest that downregulation of WDR20 due to 14q loss may be involved in the malignant transformation of ccRCCs, in part through activation of the ERK and protein kinase B/AKT pathways
WDR20 serves as a stimulatory subunit for preserving and regulating the activity of the subset of the UAF1 x USP12 complexes
This gene encodes a WD repeat-containing protein that functions to preserve and regulate the activity of the USP12-UAF1 deubiquitinating enzyme complex. Multiple alternatively spliced transcript variants have been found for this gene.
WD repeat-containing protein 20
, WD repeat domain 20
, WD repeat domain 20a
, WD repeat-containing protein 20-like