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WDR20 encodes a WD repeat-containing protein that functions to preserve and regulate the activity of the USP12-UAF1 deubiquitinating enzyme complex. Additionally we are shipping WD Repeat Domain 20 Antibodies (38) and and many more products for this protein.
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UAF1 (show WDR48 Proteins) and WDR20 interact with USP12 (show USP12 Proteins) at two distinct sites far from its catalytic center, allosterically activating the enzyme.
our data suggest that downregulation of WDR20 due to 14q loss may be involved in the malignant transformation of ccRCCs, in part through activation of the ERK (show EPHB2 Proteins) and protein kinase B/AKT (show AKT1 Proteins) pathways
WDR20 serves as a stimulatory subunit for preserving and regulating the activity of the subset of the UAF1 (show WDR48 Proteins) x USP12 (show USP12 Proteins) complexes
This gene encodes a WD repeat-containing protein that functions to preserve and regulate the activity of the USP12-UAF1 deubiquitinating enzyme complex. Multiple alternatively spliced transcript variants have been found for this gene.
WD repeat-containing protein 20
, WD repeat domain 20
, WD repeat domain 20a
, WD repeat-containing protein 20-like