anti-WD Repeat and FYVE Domain Containing 3 (WDFY3) Antibodies

WDFY3 encodes a phosphatidylinositol 3-phosphate-binding protein that functions as a master conductor for aggregate clearance by autophagy. Additionally we are shipping and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
WDFY3 23001 Q8IZQ1
WDFY3 72145 Q6VNB8
WDFY3 305164  
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Top anti-WDFY3 Antibodies at antibodies-online.com

Showing 10 out of 90 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-WDFY3 Antibody Titration:  0.2-1 ug/ml  Positive Control:  Human brain Host:  Rabbit  Target Name:  WDFY3  Sample Tissue:  Human Fetal Liver  Antibody Dilution:  1.0ug/ml 100 μL 2 to 3 Days
$319.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-WDFY3 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:12500  Positive Control:  Human Muscle 100 μL 2 to 3 Days
$289.00
Details
Mouse Goat Un-conjugated ELISA, WB   100 μg 6 to 7 Days
$429.84
Details
Guinea Pig Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$551.83
Details
Human Rabbit FITC ICC, IF, WB Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-WDFY3 Polyclonal Antibody . Tissue: Colon carcinoma cell line (RKO). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Rabbit Anti-WDFY3 Polyclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Rabbit ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60 min at RT, 5 min at RT. Localization: Cytoplasm, Nucleus, Membrane. Magnification: 60X. (A) DAPI nuclear stain. (B) Phalloidin Texas Red F-Actin stain. (C) WDFY3 Antibody. (D) Composite. Western blot analysis of Human HeLa and 293Trap cell lysates showing detection of 395.2 kDa WDFY3 protein using Rabbit Anti-WDFY3 Polyclonal Antibody . Lane 1: Molecular Weight Ladder (MW). Lane 2: Human HeLa and 293Trap cell lysates. Load: 15 µg . Block: 5% Skim Milk in 1X TBST. Primary Antibody: Rabbit Anti-WDFY3 Polyclonal Antibody  at 1:1000 for 1 hour at RT. Secondary Antibody: Goat Anti-Rabbit HRP at 1:2000 for 60 min at RT. Color Development: ECL solution for 6 min in RT. Predicted/Observed Size: 395.2 kDa. 100 μg 3 to 4 Days
$505.70
Details
Human Rabbit APC ICC, IF, WB Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-WDFY3 Polyclonal Antibody . Tissue: Colon carcinoma cell line (RKO). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Rabbit Anti-WDFY3 Polyclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Rabbit ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60 min at RT, 5 min at RT. Localization: Cytoplasm, Nucleus, Membrane. Magnification: 60X. (A) DAPI nuclear stain. (B) Phalloidin Texas Red F-Actin stain. (C) WDFY3 Antibody. (D) Composite. Western blot analysis of Human HeLa and 293Trap cell lysates showing detection of 395.2 kDa WDFY3 protein using Rabbit Anti-WDFY3 Polyclonal Antibody . Lane 1: Molecular Weight Ladder (MW). Lane 2: Human HeLa and 293Trap cell lysates. Load: 15 µg . Block: 5% Skim Milk in 1X TBST. Primary Antibody: Rabbit Anti-WDFY3 Polyclonal Antibody  at 1:1000 for 1 hour at RT. Secondary Antibody: Goat Anti-Rabbit HRP at 1:2000 for 60 min at RT. Color Development: ECL solution for 6 min in RT. Predicted/Observed Size: 395.2 kDa. 100 μg 3 to 4 Days
$514.80
Details
Human Rabbit PerCP ICC, IF, WB Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-WDFY3 Polyclonal Antibody . Tissue: Colon carcinoma cell line (RKO). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Rabbit Anti-WDFY3 Polyclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Rabbit ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60 min at RT, 5 min at RT. Localization: Cytoplasm, Nucleus, Membrane. Magnification: 60X. (A) DAPI nuclear stain. (B) Phalloidin Texas Red F-Actin stain. (C) WDFY3 Antibody. (D) Composite. Western blot analysis of Human HeLa and 293Trap cell lysates showing detection of 395.2 kDa WDFY3 protein using Rabbit Anti-WDFY3 Polyclonal Antibody . Lane 1: Molecular Weight Ladder (MW). Lane 2: Human HeLa and 293Trap cell lysates. Load: 15 µg . Block: 5% Skim Milk in 1X TBST. Primary Antibody: Rabbit Anti-WDFY3 Polyclonal Antibody  at 1:1000 for 1 hour at RT. Secondary Antibody: Goat Anti-Rabbit HRP at 1:2000 for 60 min at RT. Color Development: ECL solution for 6 min in RT. Predicted/Observed Size: 395.2 kDa. 100 μg 3 to 4 Days
$514.80
Details
Human Rabbit Atto 594 ICC, IF, WB Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-WDFY3 Polyclonal Antibody . Tissue: Colon carcinoma cell line (RKO). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Rabbit Anti-WDFY3 Polyclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Rabbit ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60 min at RT, 5 min at RT. Localization: Cytoplasm, Nucleus, Membrane. Magnification: 60X. (A) DAPI nuclear stain. (B) Phalloidin Texas Red F-Actin stain. (C) WDFY3 Antibody. (D) Composite. Western blot analysis of Human HeLa and 293Trap cell lysates showing detection of 395.2 kDa WDFY3 protein using Rabbit Anti-WDFY3 Polyclonal Antibody . Lane 1: Molecular Weight Ladder (MW). Lane 2: Human HeLa and 293Trap cell lysates. Load: 15 µg . Block: 5% Skim Milk in 1X TBST. Primary Antibody: Rabbit Anti-WDFY3 Polyclonal Antibody  at 1:1000 for 1 hour at RT. Secondary Antibody: Goat Anti-Rabbit HRP at 1:2000 for 60 min at RT. Color Development: ECL solution for 6 min in RT. Predicted/Observed Size: 395.2 kDa. 100 μg 3 to 4 Days
$516.10
Details
Human Rabbit Atto 565 ICC, IF, WB Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-WDFY3 Polyclonal Antibody . Tissue: Colon carcinoma cell line (RKO). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Rabbit Anti-WDFY3 Polyclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Rabbit ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60 min at RT, 5 min at RT. Localization: Cytoplasm, Nucleus, Membrane. Magnification: 60X. (A) DAPI nuclear stain. (B) Phalloidin Texas Red F-Actin stain. (C) WDFY3 Antibody. (D) Composite. Western blot analysis of Human HeLa and 293Trap cell lysates showing detection of 395.2 kDa WDFY3 protein using Rabbit Anti-WDFY3 Polyclonal Antibody . Lane 1: Molecular Weight Ladder (MW). Lane 2: Human HeLa and 293Trap cell lysates. Load: 15 µg . Block: 5% Skim Milk in 1X TBST. Primary Antibody: Rabbit Anti-WDFY3 Polyclonal Antibody  at 1:1000 for 1 hour at RT. Secondary Antibody: Goat Anti-Rabbit HRP at 1:2000 for 60 min at RT. Color Development: ECL solution for 6 min in RT. Predicted/Observed Size: 395.2 kDa. 100 μg 3 to 4 Days
$516.10
Details
Human Rabbit Atto 680 ICC, IF, WB Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-WDFY3 Polyclonal Antibody . Tissue: Colon carcinoma cell line (RKO). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Rabbit Anti-WDFY3 Polyclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Rabbit ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60 min at RT, 5 min at RT. Localization: Cytoplasm, Nucleus, Membrane. Magnification: 60X. (A) DAPI nuclear stain. (B) Phalloidin Texas Red F-Actin stain. (C) WDFY3 Antibody. (D) Composite. Western blot analysis of Human HeLa and 293Trap cell lysates showing detection of 395.2 kDa WDFY3 protein using Rabbit Anti-WDFY3 Polyclonal Antibody . Lane 1: Molecular Weight Ladder (MW). Lane 2: Human HeLa and 293Trap cell lysates. Load: 15 µg . Block: 5% Skim Milk in 1X TBST. Primary Antibody: Rabbit Anti-WDFY3 Polyclonal Antibody  at 1:1000 for 1 hour at RT. Secondary Antibody: Goat Anti-Rabbit HRP at 1:2000 for 60 min at RT. Color Development: ECL solution for 6 min in RT. Predicted/Observed Size: 395.2 kDa. 100 μg 3 to 4 Days
$516.10
Details

Top referenced anti-WDFY3 Antibodies

  1. Human Polyclonal WDFY3 Primary Antibody for EM, ICC - ABIN315857 : Sommi, Necchi, Vitali, Montagna, De Luigi, Salmona, Ricci, Solcia: PaCS is a novel cytoplasmic structure containing functional proteasome and inducible by cytokines/trophic factors. in PLoS ONE 2013 (PubMed)
    Show all 6 Pubmed References

  2. Cow (Bovine) Polyclonal WDFY3 Primary Antibody for WB - ABIN2784358 : Hillier, Graves, Fulton, Fulton, Pepin, Minx, Wagner-McPherson, Layman, Wylie, Sekhon, Becker, Fewell, Delehaunty, Miner, Nash, Kremitzki, Oddy, Du, Sun, Bradshaw-Cordum, Ali, Carter, Cordes, Harris et al.: Generation and annotation of the DNA sequences of human chromosomes 2 and 4. ... in Nature 2005 (PubMed)
    Show all 2 Pubmed References

  3. Human Monoclonal WDFY3 Primary Antibody for ELISA, WB - ABIN949075 : Orosco, Ross, Cates, Scott, Wu, Sohn, Pleasure, Pleasure, Adamopoulos, Zarbalis: Loss of Wdfy3 in mice alters cerebral cortical neurogenesis reflecting aspects of the autism pathology. in Nature communications 2014 (PubMed)

More Antibodies against WDFY3 Interaction Partners

Human WD Repeat and FYVE Domain Containing 3 (WDFY3) interaction partners

  1. a crucial role for ALFY in retinoid triggered maturation of acute myeloid leukemia cells, is reported.

  2. The Autophagy linked FYVE protein (Alfy), also known as WDFY3, is required for development of the central nervous system (CNS) in mice.

  3. we demonstrate that normally ALFY attenuates the canonical Wnt signaling pathway via autophagy-dependent removal specifically of aggregates of DVL3 and not of Dvl1 or Dvl2.

  4. ALFY binds selectively to LC3C and the GABARAPs through a LC3-interacting region in its WD40 domain.

  5. increasing Alfy-mediated protein degradation may be beneficial in some organs, but may be detrimental in others

  6. Data suggest that p62 and ALFY interact to organize misfolded, ubiquitinated proteins into protein bodies that become degraded by autophagy.

  7. The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy.

  8. Alfy might target cytosolic protein aggregates for autophagic degradation.

Mouse (Murine) WD Repeat and FYVE Domain Containing 3 (WDFY3) interaction partners

  1. These findings support a critical role for Wdfy3 in mitochondrial homeostasis with implications for neuron differentiation, neurodevelopment and age-dependent neurodegeneration.

  2. Data provide a novel association between WDFY3 and the RANKL-induced osteoclastogenesis pathway via the modulation of TRAF6.

  3. The authors report that this evolutionarily conserved protein is required for the formation of axonal tracts throughout the brain and spinal cord, including the formation of the major forebrain commissures.

  4. Alfy translocalization likely is involved in the pathogenesis of amyotrophic lateral sclerosis.

  5. Wdfy3 is important in regulating neural progenitor divisions, neural migration, cerebral expansion and functional organization in the developing brain. Loss-of-function leads to pathological changes characteristic of autism spectrum disorders.

  6. gene expression profiling; in situ hybridization analysis revealed that the expressed BWF1 mRNA was restricted to the marginal region both in E14 and E16 embryonic brain, but became diffuse after birth

WDFY3 Antigen Profile

Protein Summary

This gene encodes a phosphatidylinositol 3-phosphate-binding protein that functions as a master conductor for aggregate clearance by autophagy. This protein shuttles from the nuclear membrane to colocalize with aggregated proteins, where it complexes with other autophagic components to achieve macroautophagy-mediated clearance of these aggregated proteins. However, it is not necessary for starvation-induced macroautophagy.

Gene names and symbols associated with WDFY3

  • WDFY family member 4 (WDFY4) antibody
  • WD repeat and FYVE domain containing 3 (WDFY3) antibody
  • WD repeat and FYVE domain-containing protein 3 (MGYG_03998) antibody
  • WD repeat and FYVE domain containing 3 (Wdfy3) antibody
  • 2610509D04Rik antibody
  • ALFY antibody
  • AW319683 antibody
  • B930017C24 antibody
  • Bchs antibody
  • BWF1 antibody
  • D5Ertd66e antibody
  • Ggtb3 antibody
  • mKIAA0993 antibody
  • ZFYVE25 antibody

Protein level used designations for WDFY3

WD repeat and FYVE domain containing 3 , WD repeat and FYVE domain-containing protein 3 , autophagy-linked FYVE protein , beach domain, WD repeat and FYVE domain-containing protein 1 , galactosyltransferase 3 beta 1, 4

GENE ID SPECIES
100157904 Sus scrofa
461201 Pan troglodytes
10029110 Arthroderma gypseum CBS 118893
422613 Gallus gallus
23001 Homo sapiens
487841 Canis lupus familiaris
537096 Bos taurus
72145 Mus musculus
305164 Rattus norvegicus
Selected quality suppliers for anti-WDFY3 (WDFY3) Antibodies
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