WD Repeat and HMG-Box DNA Binding Protein 1 Proteins (WDHD1)

The protein encoded by WDHD1 contains multiple N-terminal WD40 domains and a C-terminal high mobility group (HMG) box. Additionally we are shipping WDHD1 Antibodies (48) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
WDHD1 11169 O75717
Mouse WDHD1 WDHD1 218973 P59328
Rat WDHD1 WDHD1 305827  
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Top WDHD1 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
Wheat germ Human GST tag 10 μg 11 to 12 Days

WDHD1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,

More Proteins for WD Repeat and HMG-Box DNA Binding Protein 1 (WDHD1) Interaction Partners

Xenopus laevis WD Repeat and HMG-Box DNA Binding Protein 1 (WDHD1) interaction partners

  1. Dna2 co-localizes in foci with RPA and is found in a complex with replication fork components And-1 and Mcm10. Dna2 interacts with the DSB repair and checkpoint proteins Nbs1 and ATM.

Human WD Repeat and HMG-Box DNA Binding Protein 1 (WDHD1) interaction partners

  1. AND-1 depletion is incompatible with proliferation, owing to cells accumulating in G2 with activated DNA damage checkpoint

  2. And-1 interacts with CtIP and that these interactions are required for DNA damage checkpoint maintenance, thereby linking DNA processing with prolonged cell cycle arrest to allow sufficient time for DNA repair.

  3. important role of And-1 in homologous recombination repair by regulating CtIP-mediated DNA double-strand break end resection

  4. findings provide important insights into the mechanistic details of human AND-1 function, advancing our understanding of replisome formation during eukaryotic replication.

  5. The WDHD1 gene, one of the genes that is upregulated in human papillomavirus E7-expressing cells, was found to play an important role in E7-induced G1 checkpoint abrogation and rereplication

  6. Results provide additional evidence suggesting that WDHD1 is involved in the mismatch repair pathway.

  7. RecQL4-dependent association of Mcm10 and Ctf4 with replication origins appears to be the first important step controlled by S phase promoting kinases and checkpoint pathways for the initiation of DNA replication in human cells.

  8. And-1 coordinates with Claspin for efficient Chk1 activation in response to replication stress.

  9. The Ctf4-CMG complex contains a homodimeric Ctf4 that acts as a platform linking polymerase alpha to the monomeric hCMG complex.

  10. And-1 together with HJURP regulates the assembly of new CENP-A onto centromeres.

  11. Human And-1 facilitates loading of the MCM2-7 helicase onto chromatin during the assembly of prereplicative complex.

  12. Data show that And-1 forms a complex with both histone H3 and Gcn5.

  13. in human cells, hCtf4 plays an essential role in DNA replication and its ability to stimulate the replicative DNA polymerases may contribute to this effect

  14. Mcm10 is required for chromatin loading of And-1.

  15. AND-1 coordinates multiple cellular events in S phase and G2 phase.

  16. Assembly of the Cdc45-Mcm2-7-GINS complex requires the Ctf4/And-1, RecQL4, and Mcm10 proteins.

WDHD1 Protein Profile

Protein Summary

The protein encoded by this gene contains multiple N-terminal WD40 domains and a C-terminal high mobility group (HMG) box. WD40 domains are found in a variety of eukaryotic proteins and may function as adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. HMG boxes are found in many eukaryotic proteins involved in chromatin assembly, transcription and replication. Alternative splicing results in two transcript variants encoding different isoforms.

Gene names and symbols associated with WDHD1

  • WD repeat and HMG-box DNA binding protein 1 (wdhd1)
  • WD repeat and HMG-box DNA binding protein 1 (WDHD1)
  • WD repeat and HMG-box DNA binding protein 1 L homeolog (wdhd1.L)
  • WD repeat and HMG-box DNA binding protein 1 (Wdhd1)
  • A630092E18 protein
  • AND-1 protein
  • and1 protein
  • CHTF4 protein
  • CTF4 protein
  • D630024B06Rik protein
  • wdhd1 protein
  • wu:fa11f10 protein
  • wu:fb77d12 protein
  • zgc:92585 protein

Protein level used designations for WDHD1

WD repeat and HMG-box DNA-binding protein 1 , WD repeat and HMG-box DNA binding protein 1 , COS2.3 , WD repeat and HMG-box DNA-binding protein 1-like , AND-1 protein , acidic nucleoplasmic DNA-binding protein 1 , Acidic nucleoplasmic DNA-binding protein 1 , CTF4, chromosome transmission fidelity factor 4 homolog

436999 Danio rerio
452918 Pan troglodytes
100024179 Monodelphis domestica
100170635 Ciona intestinalis
100356999 Oryctolagus cuniculus
100404802 Callithrix jacchus
100452140 Pongo abelii
100465042 Ailuropoda melanoleuca
695910 Macaca mulatta
100083933 Ornithorhynchus anatinus
100550441 Meleagris gallopavo
100561848 Anolis carolinensis
397870 Xenopus laevis
11169 Homo sapiens
218973 Mus musculus
423558 Gallus gallus
490701 Canis lupus familiaris
540681 Bos taurus
305827 Rattus norvegicus
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