WDYHV1 Proteins

Protein Summary

Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N- terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C- terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine (By similarity).

Gene names and symbols associated with WDYHV1

• WDYHV motif containing 1 (WDYHV1) antibody
• WDYHV motif containing 1 S homeolog (wdyhv1.S) antibody
• WDYHV motif containing 1 (wdyhv1) antibody
• WDYHV motif containing 1 (Wdyhv1) antibody

• 2410187C16Rik antibody
• AU014961 antibody
• AW550036 antibody
• C8orf32 antibody
• C14H8orf32 antibody
• Show all synonym aliases
• Ntaq1 antibody
• RGD1311362 antibody
• si:rp71-45k5.3 antibody

Protein level used designations for WDYHV1

WDYHV motif containing 1 , protein N-terminal glutamine amidohydrolase , nt(Q)-amidase , N-terminal Gln amidase , WDYHV motif-containing protein 1 , protein NH2-terminal glutamine deamidase