WDYHV Motif Containing 1 Proteins (WDYHV1)

Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N- terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C- terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine (By similarity).

• WDYHV motif containing 1 (WDYHV1)
• WDYHV motif containing 1 S homeolog (wdyhv1.S)
• WDYHV motif containing 1 (wdyhv1)
• WDYHV motif containing 1 (Wdyhv1)

• 2410187C16Rik protein
• AU014961 protein
• AW550036 protein
• C8orf32 protein
• C14H8orf32 protein
• Show all synonym aliases
• Ntaq1 protein
• RGD1311362 protein
• si:rp71-45k5.3 protein

WDYHV motif containing 1 , protein N-terminal glutamine amidohydrolase , nt(Q)-amidase , N-terminal Gln amidase , WDYHV motif-containing protein 1 , protein NH2-terminal glutamine deamidase