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WNK1 encodes a member of the WNK subfamily of serine/threonine protein kinases. Additionally we are shipping WNK1 Antibodies (165) and WNK1 Proteins (7) and many more products for this protein.
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Using small-interfering RNA-mediated WNK1 knockdown, we show autophagosome formation and autophagic flux are accelerated. In cells with reduced WNK1, basal and starvation-induced autophagy is increased. We also show that depletion of WNK1 stimulates focal class III phosphatidylinositol 3-kinase complex (PI3KC3) activity, which is required to induce autophagy.
WNK1 and the associated phosphorylation of the PCF11 CID act to promote transcript release from chromatin-associated Pol II, which in turn facilitates mRNA export to the cytoplasm
Akt3 (show AKT3 ELISA Kits) constitutively suppresses macropinocytosis in macrophages through a novel WNK1/SGK1 (show SGK1 ELISA Kits)/Cdc42 (show CDC42 ELISA Kits) pathway.
NKCC1 (show SLC12A2 ELISA Kits) and KCCs are coordinately regulated by L-WNK1 isoforms.
Single nucleotide polymorphisms STK39 (show STK39 ELISA Kits) and WNK were associated with hypertension and BP in our multicenter Belgian case-control study
these data provide insight into the mechanism regulating Cl(-) homeostasis in immature neurons, and suggest that WNK1-regulated changes in KCC2 (show SLC12A5 ELISA Kits) phosphorylation contribute to the developmental excitatory-to-inhibitory GABA sequence.
Identify a new chimeric transcript generated by the fusion of WNK1 and B4GALNT3 genes, correlated with B4GALNT3 overexpression in papillary thyroid carcinoma.
a novel gene, WNK1, for susceptibility to pelvic organ prolapse
findings indicate that the proline-rich exons are modular cassettes that convert WNK1 into a NEDD4-2 substrate, thereby linking aldosterone and other NEDD4-2-suppressing antinatriuretic hormones to NCC (show SLC12A3 ELISA Kits) phosphorylation status.
enhances BK channel function by reducing ERK1/2 (show MAPK1/3 ELISA Kits) signaling-mediated lysosomal degradation of the channel
HSN2 is a nervous system-specific exon of the WNK1 gene (WNK1/HSN2 isoform).
The differential regulation of ROMK, large-conductance Ca(2 (show CA2 ELISA Kits)+)-activated K(+) (BK) channel, BK-alpha and NKCC2 (show SLC12A1 ELISA Kits) between female and male mice, at least, were partly mediated via WNK1 pathway, which may contribute to the sexual dimorphism of plasma K(+) and blood pressure control.
this study identified the WNK1 kinase as a regulator of both integrin-mediated adhesion and T cell migration
Electrophysiological analysis showed that WNK1/HSN2 shifted the concentration of Cl(-)such that GABA signaling resulted in a less hyperpolarized state (increased neuronal activity) rather than a more hyperpolarized state (decreased neuronal activity) in mouse spinal nerves.
A high-K(+) diet induced an increase in L-WNK1 expression selectively in intercalated cells and may contribute to enhanced BK channel expression and K(+) secretion in collecting ducts.
increased protein expression levels of WNK1 and WNK4 kinases cause PHAII by KLHL3 R528H mutation due to impaired KLHL3-Cullin3-mediated ubiquitination.
study identifies a separation of functions for the WNK1-activated protein kinases OSR1 and SPAK (show STK39 ELISA Kits) in mediating proliferation, invasion, and gene expression in endothelial cells
This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined.
WNK lysine deficient protein kinase 1 isoform
, erythrocyte 65 kDa protein
, prostate-derived sterile 20-like kinase
, protein kinase with no lysine 1
, serine/threonine-protein kinase WNK1
, WNK lysine deficient protein kinase 1
, serine/threonine-protein kinase WNK1-like
, protein kinase lysine-deficient 1