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The Wilms tumor suppressor gene WT1 appears to play a role in both transcriptional and posttranscriptional regulation of certain cellular genes. Additionally we are shipping WTAP Antibodies (76) and WTAP Kits (7) and many more products for this protein.
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WTAP was over-expressed in glioma tissues, and the expression was closely correlated with glioma grade.
WTAP as a regulatory subunit is required for formation of a functional m6A methyltransferase complex including METTL3 (show METTL3 Proteins) and METTL14 (show METTL14 Proteins), which play an important role in the regulation of gene expression and alternative splicing.
WTAP regulates migration and invasion of cholangiocarcinoma cells.
WTAP has an important role in abnormal proliferation and arrested differentiation of leukemia cells, and WTAP is a novel client protein of Hsp90 (show HSP90 Proteins)
the WTAP complex is a novel component of the RNA processing machinery, implying an important role in both posttranscriptional control and cell cycle regulation.
WTAP overexpression made cancer cells more tumorigenic
WTAP level in poodocytes is a valuable alternative technique in the study of podocyte injury in diabetic nephropathy.
WTAP protein involved in the morphogenesis of the genitourinaty tract and in the etiology of isolated hypospadias.
WTAP and ATF3 (show ATF3 Proteins) Transcription Factor are activated in Wilms' tumor and accelerate tumorigenesis.
WTAP as an essential factor for the stabilization of cyclin A2 (show CCNA2 Proteins) mRNA, thereby regulating G2/M cell-cycle transition
Wtap is required for Xist-mediated silencing
findings indicate that Wtap is indispensable for differentiation of mesoderm and endoderm in the mouse embryo
The Wilms tumor suppressor gene WT1 appears to play a role in both transcriptional and posttranscriptional regulation of certain cellular genes. This gene encodes a WT1-associating protein, which is a ubiquitously expressed nuclear protein. Like WT1 protein, this protein is localized throughout the nucleoplasm as well as in speckles and partially colocalizes with splicing factors. Alternative splicing of this gene results in several transcript variants encoding three different isoforms.
Wilms tumor 1 associated protein
, Wilms' tumour 1-associating protein
, pre-mRNA-splicing regulator WTAP
, wilms tumor 1 associated protein
, pre-mRNA-splicing regulator WTAP-like
, WT1-associated protein
, female-lethal(2)D homolog
, putative pre-mRNA splicing regulator female-lethal(2D)
, wilms tumor 1-associating protein