Wiskott-Aldrich Syndrome (Eczema-thrombocytopenia) Proteins
The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton.
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Wiskott-Aldrich Syndrome (Eczema-thrombocytopenia) (WAS) (AA 2-502) protein (His tag) Protein
Wiskott-Aldrich Syndrome (Eczema-thrombocytopenia) (WAS) (AA 39-251) protein (T7 tag,His tag) Protein
Wiskott-Aldrich Syndrome (Eczema-thrombocytopenia) (WAS) (AA 1-298) protein (T7 tag,His tag) Protein
Wiskott-Aldrich Syndrome (Eczema-thrombocytopenia) (WAS) (AA 57-170) protein (GST tag) Protein
Wiskott-Aldrich Syndrome (Eczema-thrombocytopenia) (WAS) Protein Protein
Wiskott-Aldrich Syndrome (Eczema-thrombocytopenia) (WAS) Protein Protein
Wiskott-Aldrich Syndrome (Eczema-thrombocytopenia) (WAS) protein (Myc-DYKDDDDK Tag) Protein
Wiskott-Aldrich Syndrome (Eczema-thrombocytopenia) (WAS) Protein Profile
Protein Summary
The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients. A transcript variant arising as a result of alternative promoter usage, and containing a different 5' UTR sequence, has been described, however, its full-length nature is not known.
Gene names and symbols associated with WAS
- Wiskott-Aldrich syndrome (WAS) antibody
- neural Wiskott-Aldrich syndrome protein (LOC5578888) antibody
- wiskott-aldrich syndrome protein (CpipJ_CPIJ006699) antibody
- Wiskott-Aldrich syndrome (Was) antibody
- Wiskott-Aldrich syndrome L homeolog (was.L) antibody
- Wiskott-Aldrich syndrome (eczema-thrombocytopenia) b (wasb) antibody
- imd2 antibody
- SCNX antibody
- thc antibody
- thc1 antibody
- U42471 antibody
- was antibody
- wasp antibody
- wu:fk81c08 antibody
- zgc:64164 antibody
Protein level used designations for WAS
eczema-thrombocytopenia , thrombocytopenia 1 (X-linked) , wiskott-Aldrich syndrome protein , wiskott-aldrich syndrome protein , Wiskott-Aldrich syndrome homolog , wiskott-Aldrich syndrome protein homolog , Wiskott-Aldrich syndrome (eczema-thrombocytopenia) , Wiskott-Aldrich syndrome L homeolog , wiskott-Aldrich syndrome L homeolog , wasp1
| GENE ID | SPECIES |
|---|---|
| 7454 | Homo sapiens |
| 5578888 | Aedes aegypti |
| 6038460 | Culex quinquefasciatus |
| 22376 | Mus musculus |
| 317371 | Rattus norvegicus |
| 100037214 | Xenopus laevis |
| 335158 | Danio rerio |
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