WASP Protein (AA 1-502) (GST tag)

Catalog No. ABIN1989806

Product Details

Target: WASP (WAS) (Wiskott-Aldrich Syndrome (Eczema-thrombocytopenia) (WAS))

Protein Type: Recombinant

Protein Characteristics: AA 1-502

Origin: Human

Source: Wheat germ

Purification tag / Conjugate: This WASP protein is labelled with GST tag.

Application: Western Blotting (WB), ELISA, Antibody Array (AA), Affinity Purification (AP)

Purpose: WAS (Human) Recombinant Protein (P01)

Sequence: MSGGPMGGRP GGRGAPAVQQ NIPSTLLQDH ENQRLFEMLG RKCLTLATAV VQLYLALPPG AEHWTKEHCG AVCFVKDNPQ KSYFIRLYGL QAGRLLWEQE LYSQLVYSTP TPFFHTFAGD DCQAGLNFAD EDEAQAFRAL VQEKIQKRNQ RQSGDRRQLP PPPTPANEER RGGLPPLPLH PGGDQGGPPV GPLSLGLATV DIQNPDITSS RYRGLPAPGP SPADKKRSGK KKISKADIGA PSGFKHVSHV GWDPQNGFDV NNLDPDLRSL FSRAGISEAQ LTDAETSKLI YDFIEDQGGL EAVRQEMRRQ EPLPPPPPPS RGGNQLPRPP IVGGNKGRSG PLPPVPLGIA PPPPTPRGPP PPGRGGPPPP PPPATGRSGP LPPPPPGAGG PPMPPPPPPP PPPPSSGNGP APPPLPPALV PAGGLAPGGG RGALLDQIRQ GIQLNKTPGA PESSALQPPP QSSEGLVGAL MHVMQKRSRA IHSSDEGEDQ AGDEDEDDEW DD

Characteristics: Human WAS full-length ORF (AAH12738.1, 1 a.a. - 502 a.a.) recombinant protein with GST tag at N-terminal.

Purification: in vitro wheat germ expression system

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH =8.0 in the elution buffer.

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -80 °C

Storage Comment: Best use within three months from the date of receipt of this protein.

Target Details

Target: WASP (WAS) (Wiskott-Aldrich Syndrome (Eczema-thrombocytopenia) (WAS))

Alternative Name: WAS (WAS Products)

Synonyms: IMD2 Protein, SCNX Protein, THC Protein, THC1 Protein, WASP Protein, U42471 Protein, WASp Protein, Wasp Protein, imd2 Protein, thc Protein, thc1 Protein, was Protein, wasp Protein, wu:fk81c08 Protein, zgc:64164 Protein, Wiskott-Aldrich syndrome Protein, neural Wiskott-Aldrich syndrome protein Protein, wiskott-aldrich syndrome protein Protein, Wiskott-Aldrich syndrome L homeolog Protein, Wiskott-Aldrich syndrome (eczema-thrombocytopenia) b Protein, WAS Protein, LOC5578888 Protein, CpipJ_CPIJ006699 Protein, Was Protein, was.L Protein, wasb Protein

Background: Synonyms: IMD2,THC,WASP
Gene Description: Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
Gene Name: WAS
Gene Summary: The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients. A transcript variant arising as a result of alternative promoter usage, and containing a different 5' UTR sequence, has been described, however, its full-length nature is not known.
GenBank: BC012738.2, AAH12738.1

Molecular Weight: 81.62 kDa (theoreatical)

Gene ID: 7454