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WHSC1 encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. Additionally we are shipping WHSC1 Antibodies (51) and many more products for this protein.
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These results indicate that DrWhsc1 is a functional homolog of WHSC1 and that the SET domain of DrWhsc1 is essential for di-methylation of histone H3K36 in zebrafish.
Herein we report on the first fully validated WHSC1 inhibitor, PTD2, a norleucine-containing peptide derived from the histone H4 sequence. This peptide exhibits micromolar affinity towards WHSC1 in biochemical and biophysical assays. Furthermore, a crystal structure was solved with the peptide in complex with SAM (show TTN Proteins) and the SET domain of WHSC1L1 (show WHSC1L1 Proteins)
The histone methyltransferase NSD2/WHSC1/MMSET is overexpressed in a number of solid tumors but its contribution to the biology of these tumors is not well understood. Here, we describe that NSD2 contributes to the proliferation of a subset of lung cancer cell lines by supporting oncogenic RAS transcriptional responses.
MMSET-like gene signature captures a subset of high-risk myeloma patients underrepresented by conventional risk stratification platforms and defines a distinct biologic subtype.
These findings indicate that the miR (show MLXIP Proteins)-2392-MAML3/WHSC1-Slug/Twist1 (show TWIST1 Proteins) regulatory axis plays a critical role in GC metastasis.
In a murine xenograft model using t(4;14)+ KMS11 MM cells harboring an inducible MMSET shRNA, depletion of MMSET enhanced the efficacy of chemotherapy, inhibiting tumor growth and extending survival.
data suggest multiple myeloma SET domain containing protein(MMSET) may play a role in the inhibitory effect of metformin on prostate cancer and could serve as a potential novel therapeutic target for prostate cancer
NSD2 overexpression is significantly associated with high risk of relapse and poor survival in tamoxifen-treated ER-positive breast cancer patients via coordinated activation of pentose phosphate pathway enzymes.
Results show that WHSC1 is hypomethylated in cervical cancer cells and tissues. Both methylation and mRNA expression of WHSC1 were significantly correlated with lymph node metastasis and the overall survival of patients.
Results showed that high levels of MMSET in the myeloma-like cells drove the formation of hypermethyled proteoforms containing H3K36me2 co-existent with the repressive marks H3K9me2/3 and H3K27me2/3.
In MMSET-depleted cells there are defects in DNA replication and a decreased association with chromatin.
MMSET promotes AICDA (show AICDA Proteins)-mediated DNA breaks at the donor switch region during immunoglobulin class switch recombination.
Whsc1 plays an important role at several points of hematopoietic development.
findings highlight a pivotal link between an epigenetic regulator, WHSC1, and key intracellular signaling molecules, AKT, RICTOR, and Rac1, to drive prostate cancer metastasis.
WHSC1-deficient mice display craniofacial defects that overlap with Wolf-Hirschhorn syndrome, including cochlea anomalies
Histone H3 (show HIST3H3 Proteins) lysine 36 methyltransferase Whsc1 promotes the association of Runx2 (show RUNX2 Proteins) and p300 (show NOTCH1 Proteins) in the activation of bone-related genes
all of the H3K36-specific methyltransferases, including ASH1L (show ASH1L Proteins), HYPB, NSD1, and NSD2 were inhibited by ubH2A, whereas the other histone methyltransferases, including PRC2, G9a (show EHMT2 Proteins), and Pr-Set7 (show SETD8 Proteins) were not affected by ubH2A.
WHSC1 links transcription elongation to HIRA (show HIRA Proteins)-mediated histone H3.3 (show H3F3A Proteins) deposition.
H3K36me3-specific histone methyltransferase WHSC1 (also NSD2 or MMSET) functions in transcriptional regulation together with developmental transcription factors whose defects overlap with the human disease Wolf-Hirschhorn syndrome
This gene encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene maps to the 165 kb WHS critical region and has also been involved in the chromosomal translocation t(4\;14)(p16.3\;q32.3) in multiple myelomas. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Some transcript variants are nonsense-mediated mRNA (NMD) decay candidates, hence not represented as reference sequences.
Wolf-Hirschhorn syndrome candidate 1 protein
, Wolf-Hirschhorn syndrome candidate 1
, probable histone-lysine N-methyltransferase NSD2
, IL5 promoter REII region-binding protein
, histone-lysine N-methyltransferase NSD2
, multiple myeloma SET domain containing protein type III
, nuclear SET domain-containing protein 2
, trithorax/ash1-related protein 5
, multiple myeloma SET domain-containing protein
, wolf-Hirschhorn syndrome candidate 1 protein homolog