Wolf-Hirschhorn Syndrome Candidate 1 Proteins (WHSC1)

WHSC1 encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. Additionally we are shipping WHSC1 Antibodies (51) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
WHSC1 7468 O96028
Rat WHSC1 WHSC1 680537  
WHSC1 107823 Q8BVE8
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Top WHSC1 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Escherichia coli (E. coli) Human GST tag MMSET / WHSC1 - SET activity assay using Recombinant Nucleosomes as substrates. Recombinant Nucleosomes were used as substrates in an assay measuring the methyltransferase activity of MMSET / WHSC1 - SET. Activity was detected by fluorography. Recombinant MMSET / WHSC1 - SET protein gel. Recombinant MMSET / WHSC1 - SET run on an SDS-PAGE gel and stained with Coomassie blue. 50 μg Log in to see 1 to 2 Days
Baculovirus Human DYKDDDDK Tag MMSET / WHSC1 activity assay. HMT assay measuring the activity of Recombinant MMSET / WHSC1. Activity was detected by fluorography. Recombinant MMSET / WHSC1 protein gel. MMSET / WHSC1 protein was run on a 10% SDS-PAGE gel and stained with Coomassie blue. 20 μg Log in to see 1 to 2 Days

WHSC1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine)

More Proteins for Wolf-Hirschhorn Syndrome Candidate 1 (WHSC1) Interaction Partners

Zebrafish Wolf-Hirschhorn Syndrome Candidate 1 (WHSC1) interaction partners

  1. These results indicate that DrWhsc1 is a functional homolog of WHSC1 and that the SET domain of DrWhsc1 is essential for di-methylation of histone H3K36 in zebrafish.

Human Wolf-Hirschhorn Syndrome Candidate 1 (WHSC1) interaction partners

  1. Mutations in NSD1 or NSD2 are independent favorable prognostic biomarkers for laryngeal cancer.

  2. The MMSET is required for efficient NER and that it catalyzes the dimethylation of histone H4 at lysine 20 (H4K20me2).

  3. NSD2 promoted the proliferation of pancreatic beta cell lines. Moreover, ectopic expression of NSD2 significantly promoted insulin secretion. In addition, NSD2 served as a transfection factor and it was identified that NSD2 transcriptionally regulated PDX1 expression through its H3K36me2 methyltransferase activity.

  4. Herein we report on the first fully validated WHSC1 inhibitor, PTD2, a norleucine-containing peptide derived from the histone H4 sequence. This peptide exhibits micromolar affinity towards WHSC1 in biochemical and biophysical assays. Furthermore, a crystal structure was solved with the peptide in complex with SAM and the SET domain of WHSC1L1

  5. The histone methyltransferase NSD2/WHSC1/MMSET is overexpressed in a number of solid tumors but its contribution to the biology of these tumors is not well understood. Here, we describe that NSD2 contributes to the proliferation of a subset of lung cancer cell lines by supporting oncogenic RAS transcriptional responses.

  6. MMSET-like gene signature captures a subset of high-risk myeloma patients underrepresented by conventional risk stratification platforms and defines a distinct biologic subtype.

  7. These findings indicate that the miR-2392-MAML3/WHSC1-Slug/Twist1 regulatory axis plays a critical role in GC metastasis.

  8. In a murine xenograft model using t(4;14)+ KMS11 MM cells harboring an inducible MMSET shRNA, depletion of MMSET enhanced the efficacy of chemotherapy, inhibiting tumor growth and extending survival.

  9. data suggest multiple myeloma SET domain containing protein(MMSET) may play a role in the inhibitory effect of metformin on prostate cancer and could serve as a potential novel therapeutic target for prostate cancer

  10. NSD2 overexpression is significantly associated with high risk of relapse and poor survival in tamoxifen-treated ER-positive breast cancer patients via coordinated activation of pentose phosphate pathway enzymes.

  11. Results show that WHSC1 is hypomethylated in cervical cancer cells and tissues. Both methylation and mRNA expression of WHSC1 were significantly correlated with lymph node metastasis and the overall survival of patients.

  12. Results showed that high levels of MMSET in the myeloma-like cells drove the formation of hypermethyled proteoforms containing H3K36me2 co-existent with the repressive marks H3K9me2/3 and H3K27me2/3.

  13. In MMSET-depleted cells there are defects in DNA replication and a decreased association with chromatin.

  14. results identify a pivotal role for NSD2 binding to its catalytic product in regulating its cellular functions, and suggest a model for how this interaction may facilitate epigenetic spreading and propagation of H3K36me2.

  15. NSD2 preferentially catalyzes the dimethylation of H3K36 along with a reduced preference for H3K36 monomethylation

  16. Studies indicate that the NSD methyltransferases NSD1, NSD2/WHSC1/MMSET and NSD3/WHSC1L1 were overexpressed, amplified or somatically mutated in multiple types of cancer, suggesting their critical role in cancer.

  17. It was observed that RE-IIBP induces MEIS1-mediated apoptosis, which was dependent on H2BK120 ubiquitination by RNF20.

  18. Results show that WHSC1 is overexpressed in Squamous cell carcinoma of the head and neck (SCCHN) and that it promotes cell-cycle progression through activation of NEK7, indicating its potential role as an oncogenic force in SCCHN.

  19. The results describe the binding of NSD1, 2 and 3 catalytic domains (CD) on histone tails through recognition of histone-lysine and methylation properties.

  20. The role of the shorter isoform (REIIBP) in myeloma cells was characterized and identified a clear and novel interaction of REIIBP with members of the SMN complex.

Mouse (Murine) Wolf-Hirschhorn Syndrome Candidate 1 (WHSC1) interaction partners

  1. Results suggest a critical role of histone-lysine N-methyltransferase Nsd2-mediated histone H3K36 methylation in adipose tissue development and function.

  2. MMSET promotes AICDA-mediated DNA breaks at the donor switch region during immunoglobulin class switch recombination.

  3. Whsc1 plays an important role at several points of hematopoietic development.

  4. findings highlight a pivotal link between an epigenetic regulator, WHSC1, and key intracellular signaling molecules, AKT, RICTOR, and Rac1, to drive prostate cancer metastasis.

  5. WHSC1-deficient mice display craniofacial defects that overlap with Wolf-Hirschhorn syndrome, including cochlea anomalies

  6. Histone H3 lysine 36 methyltransferase Whsc1 promotes the association of Runx2 and p300 in the activation of bone-related genes

  7. all of the H3K36-specific methyltransferases, including ASH1L, HYPB, NSD1, and NSD2 were inhibited by ubH2A, whereas the other histone methyltransferases, including PRC2, G9a, and Pr-Set7 were not affected by ubH2A.

  8. WHSC1 links transcription elongation to HIRA-mediated histone H3.3 deposition.

  9. H3K36me3-specific histone methyltransferase WHSC1 (also NSD2 or MMSET) functions in transcriptional regulation together with developmental transcription factors whose defects overlap with the human disease Wolf-Hirschhorn syndrome

WHSC1 Protein Profile

Protein Summary

This gene encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene maps to the 165 kb WHS critical region and has also been involved in the chromosomal translocation t(4\;14)(p16.3\;q32.3) in multiple myelomas. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Some transcript variants are nonsense-mediated mRNA (NMD) decay candidates, hence not represented as reference sequences.

Gene names and symbols associated with WHSC1

  • nuclear receptor binding SET domain protein 2 (NSD2)
  • nuclear receptor binding SET domain protein 2 (nsd2)
  • Wolf-Hirschhorn syndrome candidate 1 (WHSC1)
  • nuclear receptor binding SET domain protein 2 (Nsd2)
  • 5830445G22Rik protein
  • 9430010A17Rik protein
  • AW555663 protein
  • C130020C13Rik protein
  • D030027O06Rik protein
  • D930023B08Rik protein
  • fc12c04 protein
  • mKIAA1090 protein
  • MMSET protein
  • NSD2 protein
  • REIIBP protein
  • RGD1565590 protein
  • si:rp71-77d7.2 protein
  • TRX5 protein
  • WHS protein
  • WHSC1 protein
  • Whsc1l protein
  • wu:fc12c04 protein
  • wu:fi20c01 protein

Protein level used designations for WHSC1

Wolf-Hirschhorn syndrome candidate 1 protein , Wolf-Hirschhorn syndrome candidate 1 , probable histone-lysine N-methyltransferase NSD2 , IL5 promoter REII region-binding protein , histone-lysine N-methyltransferase NSD2 , multiple myeloma SET domain containing protein type III , nuclear SET domain-containing protein 2 , trithorax/ash1-related protein 5 , multiple myeloma SET domain-containing protein , wolf-Hirschhorn syndrome candidate 1 protein homolog

461070 Pan troglodytes
540769 Bos taurus
100000709 Danio rerio
100051090 Equus caballus
100125213 Xenopus (Silurana) tropicalis
479077 Canis lupus familiaris
7468 Homo sapiens
422897 Gallus gallus
680537 Rattus norvegicus
107823 Mus musculus
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