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YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. Additionally we are shipping YY1 Transcription Factor Antibodies (149) and YY1 Transcription Factor Proteins (8) and many more products for this protein.
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YY1 is essential for Xenopus development in neural ectoderm differentiation, neural crest specification and directing neural crest mesenchyme formation by blocking slug
Yin Yang 1 transcription factor assembly into messenger ribonucleoprotein (show RBP31 ELISA Kits) particles requires direct RNA binding activity
Results show that the YY1-RNA interaction is highly stable, and that YY1 possesses the ability to interact with structurally divergent RNA substrates.
results suggest that YY1a regulates PS receptor expression that linked to function of PSR (show JMJD6 ELISA Kits)-phagocyte mediated apoptotic cell engulfment during development
YY1 promotes zebrafish liver steatosis and lipotoxicity by inhibiting CHOP-10 (show DDIT3 ELISA Kits) expression.
Study demonstrated that beta-arrestin1 (show ARRB1 ELISA Kits) is critically involved in zebrafish primitive hematopoiesis, where beta-arrestin1 (show ARRB1 ELISA Kits) binds to and sequesters the PcG recruiter YY1, thus relieving PcG-mediated repression of cdx4-hox (show MSH2 ELISA Kits) pathway.
YY1 promotes proliferation and migration with suppression of apoptosis via directly inhibiting MYCT1 in laryngeal cancer cells, suggesting that YY1 is a useful target as a potential oncogene (show RAB1A ELISA Kits) in laryngeal cancer development and progression.
These data suggested that YY1 may be important for apoptosis induction via the regulation of Fas during sepsis. Therefore, Fas may be a potential therapeutic target to prevent MOD through regulation of YY1 expression. Furthermore, YY1 and Fas expression in PBMCs may be used to as prognostic markers.
Study shows that the ubiquitously expressed transcription factor Yin Yang 1 (YY1) contributes to enhancer-promoter structural interactions in a manner analogous to DNA interactions mediated by CTCF (show CTCF ELISA Kits).
YY1 was over-expressed in RA which can bind to the promotor of IL-6 (show IL6 ELISA Kits) to introduce IL-6 (show IL6 ELISA Kits) expression, contributing to the inflammation of RA via stimulation of Th17 differentiation.
YY1 promotes apoptosis via upregulating Bax transcription and subsequent activation of Bax by translocation from the cytosol to the mitochondrial membrane.
High YY1 expression is associated with Lung Cancer Progression.
Low YY1 expression is associated with pancreatic ductal adenocarcinoma.
PRE-PIK3C2B interacts directly with YY1 in vitro and recruits PRC2 complex in vivo. The localization of PcG proteins including YY1 to PRE-PIK3C2B in HEK cells is decreased on knock-down of either YY1 or SUZ12.
YY1 promotes mTORC2-mediated AKT (show AKT1 ELISA Kits) activation
Yin Yang 1 (YY1) interacts with Seryl-tRNA synthetase (SerRS) to form a SerRS/YY1 complex which functions as a negative effector to regulate vegfa transcription through binding a distal segment of the vegfa promoter, while NFKB1 serves as a positive effector through outcompeting SerRS/YY1 for binding at the same distal segment.
these results suggested that the basal promoter activity of the mIRF-3 gene is regulated by transcription factors Egr2 (show EGR2 ELISA Kits) and YY1 in NIH3T3 cells
DNA binding domain of YY1 is necessary for X-chromosome inactivation in activated B cells, as ex-vivo YY1 deletion results in loss of inactive X (Xi) chromosome heterochromatin marks and up-regulation of X-linked genes.
Transcriptome analysis revealed that YY1 is required for mitochondrial gene expression, and ultrastructural analysis confirmed compromised mitochondrial integrity in the mutant intestine.
regulates broad general processes throughout all stages of B-cell differentiation: normally activates genes involved in mitochondrial bioenergetics; normally down-regulates genes involved in transcription, mRNA splicing, NF-kappaB (show NFKB1 ELISA Kits) signaling pathways, the AP-1 (show JUN ELISA Kits) transcription factor network, chromatin remodeling, cytokine signaling pathways, cell adhesion, and cell proliferation
Results indicate that YY1 plays an important role in regulating the balance between dark zone and light zone cells in germinal center (GCs (show UGCG ELISA Kits)) and between survival and death of GC B (show NPR2 ELISA Kits) cells.
YY1 is required for germinal center B cell development.
Dp71 (show DMD ELISA Kits) expression in hepatic cells is carried out, in part, by YY1-, Sp1 (show SP1 ELISA Kits)- and Sp3 (show SP3 ELISA Kits)-mediated transcription from the Dp71 (show DMD ELISA Kits) promoter.
this study shows that YY1 regulates the formation of terminal-effector CD8 (show CD8A ELISA Kits)+ T cell fates
that yin yang 1 strongly localizes in the spermatogonial stem cells and co-localizes heterogeneously with CP2c to permit spermatogenesis
YY1 and SP1 independently and cooperatively govern the Mesp1 expression during embryogenesis.
YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1.
YY1 transcription factor
, YY1 transcription factor, like
, transcription factor YY1
, Yin Yang 1
, INO80 complex subunit S
, Yin and Yang 1 protein
, delta transcription factor
, transcriptional repressor protein YY1
, GLI-Krupple related protein
, UCR-motif DNA-binding protein
, UCRBP transcription factor
, yin and yang 1