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Involved in proliferation and apoptosis in myeloid precursor cells (By similarity). Additionally we are shipping Yippee-Like 3 (Drosophila) Antibodies (16) and many more products for this protein.
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Studies with mouse YPEL3, originally named small unstable apoptot (show ARHGAP24 Proteins)ic prote (show CKAP4 Proteins)in (SUAP), confirmed th (show TP53 Proteins)at the gene encodes a growth suppressive highly unstable protein.[review]
Data show that YPEL3 is downregulated in nasopharyngeal carcinoma (NPC (show NPC1 Proteins)) cell lines and tissue samples and it suppresses NPC (show NPC1 Proteins) EMT (show ITK Proteins) and metastasis by suppressing the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling pathway.
YPEL3 expression, which is induced by the removal of estrogen or treatment with tamoxifen triggers cellular senescence in MCF-7 cells while loss of YPEL3 increases the growth rate of MCF-7 cells.
YPEL3 is downregulated in colon tumors.
In this review we show that transcriptionally active forms of p73 (show TP73 Proteins) and p63 (show RPE65 Proteins), family members of p53 (show TP53 Proteins), can transactivate the human YPEL3 gene[review]
Findings point to YPEL3 being a novel tumor suppressor, which upon induction triggers a permanent growth arrest in human tumor and normal cells.
Involved in proliferation and apoptosis in myeloid precursor cells (By similarity).
protein yippee-like 3
, small ubiquitinated apoptotic protein
, yippee-like 3