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The protein encoded by ZMYM2 is a zinc finger protein that may act as a transcription factor. Additionally we are shipping and many more products for this protein.
Showing 10 out of 45 products:
Human Polyclonal ZMYM2 Primary Antibody for ICC, IF - ABIN4367041
Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. in Nature methods 2013
In this report we described the first successful development of a model of human ZMYM2-FGFR1 (show FGFR1 Antibodies) driven AML (show RUNX1 Antibodies) in immunocompromised mice, which shows an etiology consistent with the development of the primary human disease.
Multi-SUMO binding is mediated through multi-SIM (show SIM2 Antibodies) modules, and the functional importance of these interactions is demonstrated for the transcriptional corepressor ZMYM2/ZNF198
downregulation of SUZ12 and ZNF198 leads to epigenetic reprogramming of infected hepatocytes. Because both Plk1 (show PLK1 Antibodies) and HOTAIR are elevated in many human cancers, we propose that their combined effects are involved in epigenetic reprogramming
B-lymphoblastic leukemia/lymphoma associated with t(8;13)(p11 (show S100A10 Antibodies);q12)/ ZMYM2 (ZNF198)-FGFR1 (show FGFR1 Antibodies)
We propose Plk1 activity down-regulates ZNF198 and SUZ12, thereby enhancing both HBV replication and pX-mediated oncogenic transformation.
cell transformation mediated by ZNF198-FGFR1 (show FGFR1 Antibodies) requires STAT5 (show STAT5A Antibodies) activation
ZNF198/fibroblast growth factor receptor-1 (show FGFR1 Antibodies) has signaling function comparable with interleukin-6 (show IL6 Antibodies) cytokine receptors.
SUMO-1 (show SUMO1 Antibodies), PML (show PML Antibodies) and ZNF198 colocalize to punctate structures, shown by immunocytochemistry to be PML (show PML Antibodies) bodies.
ZNF198-FGFR1 (show FGFR1 Antibodies) activated both the AKT (show AKT1 Antibodies) and mitogen activated protein kinase (show MAPK1 Antibodies) (MAPK (show MAPK1 Antibodies)) prosurvival signaling pathways, resulting in elevated phosphorylation of the AKT (show AKT1 Antibodies) target FOXO3a (show FOXO3 Antibodies) at T32 and BAD at S112, respectively.
HSPA1A (show HSPA1A Antibodies) is an important regulator of the stability and function of ZNF198 and its oncogenic derivative, ZNF198-FGFR1 (show FGFR1 Antibodies).
The study demonstrates frequent, constitutive activation of Notch1 (show NOTCH1 Antibodies) and its downstream target genes in T-cell lymphomas that arose in a murine model of Zmym2-Fgfr1 (show FGFR1 Antibodies) stem cell leukemia-lymphoma syndrome.
The protein encoded by this gene is a zinc finger protein that may act as a transcription factor. The encoded protein may be part of a BHC histone deacetylase complex. Translocation of this gene with the fibroblast growth factor receptor-1 gene (FGFR1) results in a fusion gene, which may be a cause of stem cell leukemia lymphoma syndrome (SCLL). Several transcript variants encoding the same protein have been found for this gene.
zinc finger, MYM-type 2
, zinc finger protein 198
, fused in myeloproliferative disorders protein
, rearranged in an atypical myeloproliferative disorder
, zinc finger MYM-type protein 2
, MYM-type zinc finger protein 2