Zinc Finger Protein, Multitype 1 Proteins (ZFPM1)

Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Additionally we are shipping ZFPM1 Antibodies (35) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ZFPM1 161882 Q8IX07
ZFPM1 22761 O35615
Rat ZFPM1 ZFPM1 691504  
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Top ZFPM1 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$13,741.67
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$13,741.67
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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Yeast Zebrafish His tag   1 mg Log in to see 60 to 71 Days
$2,561.17
Details

ZFPM1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Zinc Finger Protein, Multitype 1 (ZFPM1) Interaction Partners

Human Zinc Finger Protein, Multitype 1 (ZFPM1) interaction partners

  1. Forced FOG1 protein expression in K562 erythroleukemia cells induced the expression of SLC4A1 protein, but repressed that of transcription factor PU.1.

  2. GAB2, GSPT1, TFDP2 and ZFPM1 are four new susceptibility loci for testicular germ cell tumor.

  3. FOG1 is a member of the PR domain containing, zinc finger protein family of transcriptional regulators.

  4. Our results reveal that the protein structure does not affect ligand binding, and the top three TCM candidates Bittersweet alkaloid II, Eicosandioic acid, and Perivine might resolve the instability of the RbAp48-FOG1 complex

  5. FOG1, FOG2 and GATA-6 modulate the transcriptional up-regulation of HAMP in hepatocytes during inflammation.

  6. ZFPM1 that facilitates human Th1 differentiation via the downregulation of IL-4 is a potential target for the treatment of allergic diseases.

  7. Anagrelide suppresses megakaryocytopoiesis by reducing the expression levels of GATA-1 and FOG-1 via a PDEIII-independent mechanism that is differentiation context-specific and does not involve inhibition of MPL-mediated early signal transduction events

  8. The FOG-1 peptide contacts a negatively charged binding pocket on top of the RbAp48 beta-propeller that is distinct from the binding surface used by RpAp48 to contact histone H4

  9. X-linked thrombocytopenia with thalassemia from a mutation in the amino finger of GATA-1 affects DNA binding but does not affect FOG-1 interaction.(FOG1, cofactor of GATA1)

  10. Erythroid and megakaryocytic lineage differentiation and maturation are regulated via cooperation between transcription factor GATA1 and its essential cofactor FOG1. It depends on the binding of FOG1 to the N-terminalfinger of GATA1.

  11. 3D structure of a complex comprising the interaction domains of FOG1 and GATA1 reveals how zinc fingers can act as protein recognition motifs and provides a molecular explanation for how GATA-1 mutations contribute to distinct, related genetic diseases.

  12. Megakaryocytes from idiopathic myelofibrosis patients have reduced GATA-1 content, possibly contributing to disease pathogenesis as in the GATA-1(low) mice.

  13. Data verified the function of Zfpm-1 during erythropoietic differentiation.

  14. FOG-1 inhibits mast-cell differentiation in a differentiation stage-dependent manner, and its effects are produced via different molecular mechanisms.

  15. two novel mechanisms for the regulation of GATA1 interaction with FOG1-dependent protein complexes through the production of two translational isoforms with differential interaction profiles and independent nuclear localization controls.

Mouse (Murine) Zinc Finger Protein, Multitype 1 (ZFPM1) interaction partners

  1. FOG1 is a member of the PR domain containing, zinc finger protein family of transcriptional regulators.

  2. the role of FOG-1 in B lymphocytes

  3. FOG-1 is required for the formation of all committed Mk- and E-lineage progenitors. It mediates transcriptional megakaryocyte/erythrocyte programming of HSCs as well as their subsequent Mk/E-lineage commitment.

  4. Disruption of the GATA1/FOG1/NuRD transcriptional system results in a complex, pleiotropic platelet defect beyond gray platelet syndrome-like macrothrombocytopenia.

  5. These results implicate FOG1 and 2 and CTBPs as partners of GATA proteins in the control of adipocyte proliferation and differentiation.

  6. role of the hematopoietic transcription factor GATA-1, its cofactor FOG-1, and the associated chromatin remodeling complex NuRD in the developmental silencing of HBG1 and HBG2 gene expression

  7. The continuous presence of GATA1, FOG1, and NuRD is required to maintain lineage fidelity throughout megakaryocyte-erythroid ontogeny.

  8. Data demonstrate that sumoylation of GATA-1 K137 promotes transcriptional activation only at target genes requiring the coregulator Friend of GATA-1 (FOG-1).

  9. Gene expression analysis in primary mutant erythroid cells and megakaryocytes revealed an essential function for NuRD during both the repression and activation of select Gata-1/Fog1 target genes.

  10. Homozygous Fog1(R3K5A) mice were found to have splenomegaly, extramedullary erythropoiesis, granulocytosis and thrombocytopaenia secondary to a block in megakaryocyte maturation.

  11. Interaction between FOG-1 and the corepressor C-terminal binding protein is dispensable for normal erythropoiesis in vivo.

  12. may modulate the fate of a bipotential erythroid/megakaryocytic precursor cell.

  13. requires an interaction with either GATA-1 or -2 as part of its essential role in early megakaryopoiesis

  14. FOG-2, in addition to GATA-4, has a role in early gonadal development and sexual differentiation, and FOG-1 at later fetal stages, while GATA-1 executes its action postnatally

  15. plays a role in the control of megakaryocyte-specific gene expression with gata-1: Ets transcription factors also have a role

  16. nonredundant requirement for FOG-1 in the outlet tract and atrioventricular valves of the heart that depend on expression in endothelial-derived tissue and presumably reflect cooperation with the GATA-4/5/6 subfamily

  17. Transgene expression comparable to the endogenous GATA-1 level resulted in much lower frequency of rescue, indicating that the GATA-1-FOG-1 association is critical for normal embryonic hematopoiesis.

  18. the alpha-helix of FOG-ZF3 recognizes a C-terminal portion of the TACC3 coiled-coil

  19. Status of differentiation depends on FOG-1 protein.

  20. GATA-1 and its cofactor FOG-1 are required for the physical interaction between the beta-globin locus control region (LCR) and the beta-major globin promoter.

Xenopus laevis Zinc Finger Protein, Multitype 1 (ZFPM1) interaction partners

  1. a requirement for FOG and its interaction with NuRD during primitive erythropoiesis

Zebrafish Zinc Finger Protein, Multitype 1 (ZFPM1) interaction partners

  1. Loss of zinc finger protein multitype 1 (Zfpm1) activity resulted in over-activation of Neuregulin-ErbB signaling and abnormally elevated cardiomyocyte proliferation.

  2. we identified 2 cis-regulatory elements that control the tissue-specific gene expression of FOG-1.

ZFPM1 Protein Profile

Protein Summary

Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2.

Gene names and symbols associated with ZFPM1

  • zinc finger protein, FOG family member 1 (ZFPM1)
  • zinc finger protein, multitype 1 (Zfpm1)
  • zinc finger protein, FOG family member 1 L homeolog (zfpm1.L)
  • zinc finger protein, FOG family member 1 (zfpm1)
  • fog protein
  • FOG-1 protein
  • fog1 protein
  • si:dkey-20g6.1 protein
  • si:dkey-38l12.1 protein
  • Xfog protein
  • ZC2HC11A protein
  • ZFPM1 protein
  • ZNF89A protein
  • ZNF408 protein
  • ZNF469 protein

Protein level used designations for ZFPM1

FOG-1 , friend of GATA 1 , friend of GATA protein 1 , friend of GATA-1 , zinc finger protein 89A , zinc finger protein ZFPM1 , zinc finger protein, multitype 1 , Friend of GATA 1 , Friend of GATA-1 , Friend of GATA protein 1 , zinc finger protein FOG , friend of Gata1 , friend-of-GATA 1 , zinc finger protein FOG1 , zinc finger protein 469 , zinc finger protein ZFPM1-like

GENE ID SPECIES
161882 Homo sapiens
22761 Mus musculus
398166 Xenopus laevis
407655 Danio rerio
415835 Gallus gallus
454304 Pan troglodytes
528338 Bos taurus
100387228 Callithrix jacchus
691504 Rattus norvegicus
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