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The protein encoded by ZNF278 contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation.
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this study show that PATZ1 expression correlates positively with BAX (show BAX Proteins) and negatively with BCL6 (show BCL6 Proteins) and survival in human diffuse large B cell lymphomas
Our results suggest that PATZ1 and PP4R2 (show PPP4R2 Proteins) provide negative feedback on IKK (show CHUK Proteins)/NF-kappaB (show NFKB1 Proteins) signaling to prevent cancer cells from over-stimulation from cellular stimuli
The derived allele of rs174557, which is the common variant in most populations, diminishes binding of PATZ1, a transcription factor conferring allele-specific downregulation of FADS1 (show FADS1 Proteins).
Loss of PATZ1 expression is associated with thyroid cancer progression.
Results show that PATZ1 binds to p53 (show TP53 Proteins) and inhibits p53 (show TP53 Proteins)-dependent transcription activation.
these results propose that Patz1 is important for ESC pluripotency.
The data support a PATZ1 tumour-suppressive function based on its ability to enhance p53 (show TP53 Proteins)-dependent transcription and apoptosis.
PATZ1 may have an important role in the regulation of EC senescence through an ROS (show ROS1 Proteins)-mediated p53 (show TP53 Proteins)-dependent pathway and contribute to vascular diseases associated with aging.
these results showed a potentially novel mechanism of cAMP signaling mediated through the interaction of RIalpha (show PRKAR1A Proteins) with PATZ1.
MAZR and MITF (show MITF Proteins) synergistically transactivated the mMCP-6 gene. MAZR appeared to play important roles in the normal phenotypic expression of mast cells in association with MITF (show MITF Proteins)
endothelial PATZ1 thus potently inhibits endothelial function and angiogenesis via inhibition of FABP4 (show FABP4 Proteins) expression, and abnormal induction of endothelial PATZ1 may contribute to multiple aspects of vascular dysfunction in diabetes
Together, these results suggest a novel mechanism regulating endothelial PATZ1 expression based on the down-regulation of miR (show MLXIP Proteins)-24 expression caused by hyperglycemia. Interfering with PATZ1 expression via miRNAs or miRNA mimics could potentially represent a new way to target endothelial PATZ1-dependent signaling of vascular dysfunction in diabetes.
the repression of ThPOK (show ZBTB7B Proteins) during CD8 (show CD8A Proteins) lineage differentiation is mediated by the synergistic activity of the transcription factor MAZR and Runx/CBFbeta (show CBFB Proteins) complexes.
analysis of embryos in which Patz1 was disrupted revealed the presence of severe defects in the CNS and in the cardiac outflow tract, which eventually lead to a pre-mature in utero death during late gestation or soon after birth
controls the CD4 (show CD4 Proteins) versus CD8 (show CD8A Proteins) lineage fate of double-positive thymocytes
results demonstrate epigenetic control of the Cd8 (show CD8A Proteins) loci and identify MAZR as an important regulator of Cd8 (show CD8A Proteins) expression
The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated t1\;22p36.1\;q12. The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene.
zinc finger protein 278
, BTB-POZ domain zinc finger transcription factor
, BTB/POZ domain zinc finger transcription factor
, MAZ-related factor
, POZ-, AT hook-, and zinc finger-containing protein 1
, POZ-AT hook-zinc finger protein
, protein kinase A RI subunit alpha-associated protein
, zinc finger and BTB domain-containing protein 19
, zinc finger sarcoma gene protein
, POZ and AT hook containing zinc finger 1 long C isoform
, transcription factor (MAZ-related) MAZR