Zinc Finger Protein 278 Proteins (ZNF278)

The protein encoded by ZNF278 contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Additionally we are shipping Zinc Finger Protein 278 Antibodies (22) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ZNF278 23598 Q9HBE1
Mouse ZNF278 ZNF278 56218  
Rat ZNF278 ZNF278 305471  
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Top Zinc Finger Protein 278 Proteins at antibodies-online.com

Showing 3 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,626.73
Details
Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$338.33
Details
Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Log in to see Available
$284.90
Details

ZNF278 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,

More Proteins for Zinc Finger Protein 278 (ZNF278) Interaction Partners

Human Zinc Finger Protein 278 (ZNF278) interaction partners

  1. The results of IHC and qPCR analyses showed that the expression of PATZ1 in cancerous tissue was significantly lower than that in non-cancerous tissues. Meanwhile, PATZ1 expression was significantly associated with tumor differentiation and LN metastasis.

  2. ZNF278 played a prominent role in the pathogenesis of colorectal cancer (CRC), and promoted CRC cell proliferation via the ERK/MAPK pathway, suggesting that it may act as a potential target in the diagnosis or treatment of CRC

  3. this study show that PATZ1 expression correlates positively with BAX and negatively with BCL6 and survival in human diffuse large B cell lymphomas

  4. Our results suggest that PATZ1 and PP4R2 provide negative feedback on IKK/NF-kappaB signaling to prevent cancer cells from over-stimulation from cellular stimuli

  5. The derived allele of rs174557, which is the common variant in most populations, diminishes binding of PATZ1, a transcription factor conferring allele-specific downregulation of FADS1.

  6. Loss of PATZ1 expression is associated with thyroid cancer progression.

  7. Results show that PATZ1 binds to p53 and inhibits p53-dependent transcription activation.

  8. these results propose that Patz1 is important for ESC pluripotency.

  9. The data support a PATZ1 tumour-suppressive function based on its ability to enhance p53-dependent transcription and apoptosis.

  10. PATZ1 may have an important role in the regulation of EC senescence through an ROS-mediated p53-dependent pathway and contribute to vascular diseases associated with aging.

  11. these results showed a potentially novel mechanism of cAMP signaling mediated through the interaction of RIalpha with PATZ1.

  12. We report here the isolation and characterization of two novel nuclear BTB/POZ domain zinc finger isoformsthat are specifically expressed in early hippocampal neurons, cerebellar granule cells, and gliogenic progenitors as well as in differentiated glia

  13. MAZR and MITF synergistically transactivated the mMCP-6 gene. MAZR appeared to play important roles in the normal phenotypic expression of mast cells in association with MITF

  14. The results show that ZNF278 promotes cell growth, and its knockdown suppresses cell proliferation. ZNF278 could be a potential proto-oncogene in colorectal cancer.

  15. The short isoform of the Zinc finger Sarcoma Gene (ZSG) was isolated as a RNF4 interacting protein.

Mouse (Murine) Zinc Finger Protein 278 (ZNF278) interaction partners

  1. endothelial PATZ1 thus potently inhibits endothelial function and angiogenesis via inhibition of FABP4 expression, and abnormal induction of endothelial PATZ1 may contribute to multiple aspects of vascular dysfunction in diabetes

  2. Together, these results suggest a novel mechanism regulating endothelial PATZ1 expression based on the down-regulation of miR-24 expression caused by hyperglycemia. Interfering with PATZ1 expression via miRNAs or miRNA mimics could potentially represent a new way to target endothelial PATZ1-dependent signaling of vascular dysfunction in diabetes.

  3. the repression of ThPOK during CD8 lineage differentiation is mediated by the synergistic activity of the transcription factor MAZR and Runx/CBFbeta complexes.

  4. Results show that PATZ1 binds to p53 and inhibits p53-dependent transcription activation.

  5. The data support a PATZ1 tumour-suppressive function based on its ability to enhance p53-dependent transcription and apoptosis.

  6. analysis of embryos in which Patz1 was disrupted revealed the presence of severe defects in the CNS and in the cardiac outflow tract, which eventually lead to a pre-mature in utero death during late gestation or soon after birth

  7. PATZ1 may have an important role in the regulation of EC senescence through an ROS-mediated p53-dependent pathway and contribute to vascular diseases associated with aging.

  8. controls the CD4 versus CD8 lineage fate of double-positive thymocytes

  9. MAZR and MITF synergistically transactivated the mMCP-6 gene. MAZR appeared to play important roles in the normal phenotypic expression of mast cells in association with MITF

  10. results demonstrate epigenetic control of the Cd8 loci and identify MAZR as an important regulator of Cd8 expression

Zinc Finger Protein 278 (ZNF278) Protein Profile

Protein Summary

The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated t1\;22p36.1\;q12. The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene.

Gene names and symbols associated with ZNF278

  • POZ/BTB and AT hook containing zinc finger 1 (PATZ1)
  • POZ/BTB and AT hook containing zinc finger 1 S homeolog (patz1.S)
  • POZ (BTB) and AT hook containing zinc finger 1 (Patz1)
  • POZ-, AT hook-, and zinc finger-containing protein 1 (LOC100153931)
  • 8430401L15Rik protein
  • AI447519 protein
  • dJ400N23 protein
  • Mazr protein
  • Patz protein
  • RIAZ protein
  • ZBTB19 protein
  • Zfp278 protein
  • Znf278 protein
  • ZSG protein

Protein level used designations for ZNF278

zinc finger protein 278 , BTB-POZ domain zinc finger transcription factor , BTB/POZ domain zinc finger transcription factor , MAZ-related factor , POZ-, AT hook-, and zinc finger-containing protein 1 , POZ-AT hook-zinc finger protein , protein kinase A RI subunit alpha-associated protein , zinc finger and BTB domain-containing protein 19 , zinc finger sarcoma gene protein , POZ and AT hook containing zinc finger 1 long C isoform , transcription factor (MAZ-related) MAZR

GENE ID SPECIES
100058375 Equus caballus
733194 Xenopus laevis
416963 Gallus gallus
23598 Homo sapiens
486365 Canis lupus familiaris
100328729 Oryctolagus cuniculus
56218 Mus musculus
305471 Rattus norvegicus
532416 Bos taurus
100153931 Sus scrofa
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