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Function as a transcriptional repressor for PRDM1 (By similarity).. Additionally we are shipping Zinc Finger Protein 340 Proteins (2) and and many more products for this protein.
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Human Polyclonal ZNF340 Primary Antibody for IHC, IHC (p) - ABIN4366674
Wang, Sun, Kumar, Puerta, Jo, Rezvan: ZBTB46 is a shear-sensitive transcription factor inhibiting endothelial cell proliferation via gene expression regulation of cell cycle proteins. in Laboratory investigation; a journal of technical methods and pathology 2019
Human Polyclonal ZNF340 Primary Antibody for ELISA - ABIN4220010
Mertens-Talcott, Chintharlapalli, Li, Safe: The oncogenic microRNA-27a targets genes that regulate specificity protein transcription factors and the G2-M checkpoint in MDA-MB-231 breast cancer cells. in Cancer research 2007
ZBTB46 is able to clearly define the dendritic cell identity of many previously unclassified histiocytic disease subtypes. All examined cases of Langerhans cell histiocytosis and histiocytic sarcoma expressed ZBTB46, while all cases of blastic plasmacytoid dendritic cell neoplasm, chronic myelomonocytic leukemia, juvenile xanthogranuloma, Rosai-Dorfman disease, and Erdheim-Chester disease failed to express ZBTB46.
Authors report a novel tumor promoter, ZBTB46, which is negatively regulated by AR signaling via microRNA (miR)-1-mediated downregulation. ZBTB46 is associated with malignant prostate cancer and is essential for metastasis.
A single nucleotide polymorphisn in ZBTB46, rs6062314, is associated with an increased genetic risk for multiple sclerosis.
Zbtb46 is a repressor of a transcriptional network that is extinguished upon immune stimulation by TLR ligands. This network is in part responsible for maintaining dendritic cells quiescence in the steady state.
Zbtb46 may help enforce dendritic cell identity by restricting responsiveness to non-dendritic cells growth factors and may serve as a useful marker to identify rare dendritic cell progenitors
expression of the Btbd4 defines the classical dendritic cell lineage
Function as a transcriptional repressor for PRDM1 (By similarity).
BTB (POZ) domain containing 4
, BTB-ZF protein expressed in effector lymphocytes
, BTB/POZ domain-containing protein 4
, zinc finger and BTB domain-containing protein 46
, zinc finger protein 340