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Involved in the reprogramming of X-chromosome inactivation during the acquisition of pluripotency. Additionally we are shipping ZFP42 Antibodies (117) and ZFP42 Kits (1) and many more products for this protein.
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Results provide evidence that bFGF regulates stemness maintenance in stem cells isolated from human exfoliated deciduous teeth (SHEDs) by enhancing REX-1 mRNA expression via the FGFR and Akt signaling pathways. Moreover, IL-6 is also involved in the bFGF-induced REX1 expression.
Results show that a novel pluripotency regulator, REX1, is essential for pluripotency and reprogramming.
hRex1 binds to the hRex1 promoter region at -298 bp and positively regulates hRex1 transcription, but this regulation is lost in PC-3 (show PCSK1 Proteins) human prostate cancer cells.
REX1 functions in normal adult epithelial cells and tumorigenic stem cells.
Data show that Oct-4 (show POU5F1 Proteins), Rex-1, and Gata-4 (show GATA4 Proteins) expression in human mesenchymal stem cells increases cell differentiation efficiency but not hTERT expression.
MAPCs express the OCT4 and REX1 transcription factors, two specific markers of undifferentiated embryonic stem (ES) cells.
Data show that zinc finger protein 42 (Rex1) and zinc finger and SCAN domain containing 4D/4C (Zscan4D/4C) correlate with the cell-cycle length under different mechanisms.
Rex1 plays a role during preimplantation development (show MTA2 Proteins) and alters expression levels of Zscan4 (show ZSCAN4 Proteins).
Results show that Rex1 regulates endogenous retroviral element expression in mouse embryonic stem cells and during pre-implantation development and suggest that Rex1 and its relatives have evolved as regulators of endogenous retroviral transcription.
RNF12 causes REX1 breakdown through dose-dependent catalysis, thereby representing an important pathway to initiate X-chromosome inactivation
the involvement of Rex-1 in control of Polycomb (show CBX2 Proteins) target genes during pluripotency or differentiation.
loss of Rex1 leads to impaired testicular function.
the functional connection of Rex1 to genomic imprinting represents another case where newly made genes have co-evolved with lineage-specific phenomena.
Embryonic stem cell marker Rex-1 and the pluripotent stem cell marker Oct-4 (show POU5F1 Proteins) are spontaneously expressed by untreated mesenchymal stem cells.
Rex1, which is highly expressed in stem cells, inhibits signaling via the Janus kinase (JAK (show JAK3 Proteins))/signal transducer and activator of transcription (STAT (show STAT1 Proteins)) pathway, thereby modulating the differentiation of F9 cells.
Involved in the reprogramming of X-chromosome inactivation during the acquisition of pluripotency. Required for efficient elongation of TSIX, a non-coding RNA antisense to XIST. Binds DXPas34 enhancer within the TSIX promoter. Involved in ES cell self-renewal.
, REX1 transcription factor
, reduced expression protein 1
, zinc finger protein 42 homolog
, zinc finger protein 754
, zinc finger protein 42