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The protein encoded by 104125 is a nuclear protein that belongs to the family of Kruppel-like C2H2 zinc finger proteins.
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In vivo, vitamin A supplementation prevents obesity, downregulates Gadd45a (show GADD45A Antibodies) expression, and reduces GADD45A (show GADD45A Antibodies) binding and DNA demethylation in the Zfp423 promoter.
ZFP423 to be expressed in the developing cortex and promote RA-dependent neuronal differentiation.
Zfp423/ZNF423 has a role in regulating cell cycle progression, the mode of cell division and the DNA-damage response in Purkinje neuron progenitors
These data identify Zfp423 as a molecular brake on adipocyte thermogenesis.
loss of Zfp423 alters expression of several genes encoding key cilium components, including increased expression of Tulp3 (show TULP3 Antibodies). Tulp3 (show TULP3 Antibodies) is a direct binding target of Zfp423 and reducing the overexpression of Tulp3 (show TULP3 Antibodies) in Zfp423-deficient cells suppresses Smoothened translocation defects.
Data show that the expression of miR (show MLXIP Antibodies)-195a is regulated during adipocyte differentiation and identified Zfp423 as its novel target.
the antiadipogenic function of Zfp521 (show ZNF521 Antibodies) is mostly exerted through repression of Zfp423 and the downstream target PPAR-gamma (show PPARG Antibodies) gene.
Zfp423 binds autoregulatory sites in a developmental cell culture model.
Maternal obesity enhanced Zfp423 expression and adipogenic differentiation during fetal development, at least partially through reducing DNA methylation (show HELLS Antibodies) in the Zfp423 promoter.
Constitutive expression of a C-terminal mutant OAZ (show OAZ1 Antibodies) that selectively disrupts OAZ (show OAZ1 Antibodies)-O/E interaction while retaining other activities, exhibits apparently normal OSN (show SPARC Antibodies) differentiation.
ZFP423 coordinates Notch1 (show NOTCH1 Antibodies) and bone morphogenetic protein signaling, selectively up-regulating Hes5 (show HES5 Antibodies) gene expression.
We identified calmodulin-like protein 3 (CALML3 (show CALML3 Antibodies)) as a key sensor of this SNP and a coregulator of ERalpha (show ESR1 Antibodies), which contributes to differential gene transcription regulation in an estrogen and SERM-dependent fashion. Furthermore, using CRISPR/Cas9-engineered ZR75-1 breast cancer cells with different ZNF423 SNP genotypes, striking differences in cellular responses to SERMs and PARP (show COL11A2 Antibodies) inhibitors, alone or in combination
We report that CTSO (show CTSK Antibodies) reduces the protein levels of BRCA1 and ZNF423 through cysteine proteinase-mediated degradation. We also have identified a series of transcription factors of BRCA1 that are regulated by CTSO (show CTSK Antibodies) at the protein level.
two multi-zinc finger transcription cofactors named ZNF423 and ZNF521 (show ZNF521 Antibodies) have been characterised as potent inhibitors of EBF1 (show EBF1 Antibodies) and are emerging as potentially relevant contributors to the development of B-cell leukaemias
ZNF423 expression is associated with poor outcome of ETV6 (show ETV6 Antibodies)-RUNX1 (show RUNX1 Antibodies)-negative B precursor acute lymphoblastic leukemia patients.
OAZ (show OAZ1 Antibodies) gene expression was highly enriched in mesenchymal stem cells (MSCs) compared with peripheral blood leukocytes and was increased in patients with systemic lupus erythematosus (SLE) compared with control subjects.
These findings suggest that expression of UBR5 (show UBR5 Antibodies)-ZNF423 protein might contribute to the transformation of a subset of Nasopharyngeal carcinoma
Study identifies by whole-exome resequencing, mutations of MRE11 (show MRE11A Antibodies), ZNF423, and CEP164 (show CEP164 Antibodies) as causing Nephronophthisis-related ciliopathies.
Elevated expression of OAZ (show OAZ1 Antibodies) transcripts in systemic lupus erythematosus PBLs were strongly correlated with disease activity.
The expression level of OAZ (show OAZ1 Antibodies) mRNA in the bone marrow and peripheral blood of SLE patients was significantly increased than those observed in normal controls.
Low ZNF423 expression is associated with neuroblastoma (show ARHGEF16 Antibodies).
Zfp423 is a critical regulator of adipogenesis in stromal vascular cells of bovine muscle.
The protein encoded by this gene is a nuclear protein that belongs to the family of Kruppel-like C2H2 zinc finger proteins. It functions as a DNA-binding transcription factor by using distinct zinc fingers in different signaling pathways. Thus, it is thought that this gene may have multiple roles in signal transduction during development. Mutations in this gene are associated with nephronophthisis-14 and Joubert syndrome-19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
early B-cell factor associated zinc finger protein
, early B-cell factor associated zinc finger transcription factor
, early B-cell factor-associated zinc finger protein
, olf1/EBF-associated zinc finger protein
, smad- and Olf-interacting zinc finger protein
, zinc finger protein 104
, Olf-1/EBF associated Zn finger protein Roaz
, OLF-1/EBF associated zinc finger
, Smad- and Olf-interacting zinc finger protein
, zinc finger protein 423