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May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery.
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Human Polyclonal ZNF803 Primary Antibody for ELISA, WB - ABIN447336
Rathert, Dhayalan, Murakami, Zhang, Tamas, Jurkowska, Komatsu, Shinkai, Cheng, Jeltsch: Protein lysine methyltransferase G9a acts on non-histone targets. in Nature chemical biology 2008
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Human Polyclonal ZNF803 Primary Antibody for ICC, IF - ABIN4366121
Isbel, Prokopuk, Wu, Daxinger, Oey, Spurling, Lawther, Hale, Whitelaw: Wiz binds active promoters and CTCF-binding sites and is required for normal behaviour in the mouse. in eLife 2016
Disrupting the association of G9a-GLP with chromatin by depleting WIZ resulted in altered gene expression and protein-protein interactions that were distinguishable from that of small molecule-based inhibition of G9a/GLP
Data indicate zinc finger proteins ZNF644 and WIZ as two core subunits in the histone-lysine N-methyltransferase G9a/GLP complex, and interact with the transcription activation domain of G9a and GLP.
Chromatin immunoprecipitation-DNA sequence analysis was performed in adult cerebellum and Wiz peaks were found at promoters and transcription factor CTCF binding sites.
Wiz plays a major role in G9a/GLP heterodimer formation in cultured stem cells.
May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization (By similarity).
, WIZ zinc finger
, widely-interspaced zinc finger motifs
, widely-interspaced zinc finger-containing protein
, zinc finger protein 803