Zinc Finger Protein ZIC 1 Proteins (ZIC1)

ZIC1 encodes a member of the ZIC family of C2H2-type zinc finger proteins. Additionally we are shipping ZIC1 Antibodies (80) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ZIC1 7545 Q15915
Rat ZIC1 ZIC1 64618  
Mouse ZIC1 ZIC1 22771 P46684
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Top ZIC1 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Log in to see Available
Yeast Xenopus laevis His tag   1 mg Log in to see 60 to 71 Days
Yeast Chicken His tag   1 mg Log in to see 60 to 71 Days

ZIC1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,

More Proteins for Zinc Finger Protein ZIC 1 (ZIC1) Interaction Partners

Human Zinc Finger Protein ZIC 1 (ZIC1) interaction partners

  1. Two proposed mechanisms for Zic-mediated cerebellar developmental control have been documented: regulation of neuronal progenitor proliferation-differentiation and the patterning of the cerebellar primordium. Clinical studies have also revealed that ZIC1 gain of function mutations contribute to coronal craniosynostosis, a rare skull malformation.

  2. By unbiased genome-wide DNA methylation (show HELLS Proteins) profiling and comprehensive stepwise verification and validation studies using in vitro and patient-derived samples, we identified 3 promising methylation markers (GHSR (show GHSR Proteins), SST (show SST Proteins), and ZIC1) associated with a 3q gain for the detection of cervical (pre)cancer

  3. down-regulated expression of ZIC1 contributed to the inhibition of cell proliferation, and inhibited the growth of tumor

  4. our results suggest that the Zic1 promoter methylation rate in plasma-derived DNA is of great significance for the early screening of gastric cancer and monitoring of tumorigenesis

  5. Gain-of-Function Mutations in ZIC1 Are Associated with Coronal Craniosynostosis and Learning Disability.

  6. ZIC1 might play a role in the development of Ovarian Cancer, and may be a therapeutic target in OC.

  7. aberrant methylation is an important mechanism for ZIC1 inactivation in Hepatocellular carcinoma (HCC (show FAM126A Proteins)).

  8. ZIC1 is frequently inactivated by promoter hypermethyaltion and functions as a tumor suppressor in thyroid cancer through modulating PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) and MAPK (show MAPK1 Proteins) signaling pathways and transcription factor FOXO3a (show FOXO3 Proteins).

  9. Loss of ZIC1 expression is associated with malignant pleural mesothelioma.

  10. Methylation of ZIC1, a putative tumor suppressor, may be a novel determinant of ovarian cancer outcome

Xenopus laevis Zinc Finger Protein ZIC 1 (ZIC1) interaction partners

  1. snai2 and sox10 (show SOX10 Proteins) expression was severely impaired upon manipulation of Znf703 (show ZNF703 Proteins) expression levels in the embryo suggesting that Znf703 (show ZNF703 Proteins) participates in neural crest formation downstream of Pax3 (show PAX3 Proteins) and Zic1 in Xenopus

  2. Zic1, expressed at the anterior neural plate, is necessary and sufficient to promote placode fate.

  3. Pax3 (show PAX3 Proteins) and Zic1 trigger the early neural crest gene regulatory network by the direct activation of multiple key neural crest specifiers.

  4. Pax3 (show PAX3 Proteins) and Zic1 drive induction and differentiation of multipotent, migratory, and functional neural crest in Xenopus embryos.

  5. XMeis3 (show MEIS3 Proteins) protein knock down also causes a loss of primary neuron and neural crest cell lineages, without altering expression of Zic, Sox (show PIPOX Proteins) or Pax3 (show PAX3 Proteins) genes.

  6. Co-activation of Pax3 (show PAX3 Proteins) and Zic1, in concert with Wnt (show WNT2 Proteins), plays a decisive role for early neural crest determination in the correct place of the Xenopus ectoderm.

  7. These data suggest that interruption of BMP signaling facilitates neural determination via a complex mechanism, involving multiple regulatory factors that cooperate to control zic1 expression

  8. Zic1 directly upregulated the Xfeb gene during early neural development.

  9. Zic1 is an activator of Wnt (show WNT2 Proteins) signaling.

  10. Data show that Pax3 (show PAX3 Proteins) and Zic1 are necessary and sufficient to promote hatching gland and preplacodal fates, respectively, and that their combined activity is essential to specify the neural crest.

Mouse (Murine) Zinc Finger Protein ZIC 1 (ZIC1) interaction partners

  1. Geminin (show GMNN Proteins) and Zic1 could cooperatively activate the expression of several shared targets encoding transcription factors that control neurogenesis, neural plate patterning, and neuronal differentiation.

  2. Zic1 and Zic2 (show ZIC2 Proteins) proteins are essential to control the balance between two defined neuron types in the postnatal forebrain.

  3. Brn2 (show POU3F2 Proteins)-Zic1 axis is essential to specify neural fate in retinoic-acid-treated embryonic stem cells.

  4. Zic1 and Zic2 (show ZIC2 Proteins) are required for coordinating mature neuronal gene expression patterns.

  5. Association with DNA-bound Pax3 (show PAX3 Proteins) strengthens the ability of both Zic1 and Gli2 to transactivate Myf5 (show MYF5 Proteins) in the epaxial somite.

  6. Zic1 and Zic4 (show ZIC4 Proteins) have both Shh (show SHH Proteins)-dependent and -independent roles during cerebellar development and multiple developmental disruptions underlie Zic1/4-related Dandy-walker malformation.

  7. Myf5 (show MYF5 Proteins) activation in newly forming somites is delayed in Zic2 (show ZIC2 Proteins) mutant embryos until the time of Zic1 activation, and both Zic2 (show ZIC2 Proteins) and Myf5 (show MYF5 Proteins) require noggin (show NOG Proteins) for their activation

  8. Zic1, a neural developmental transcription factor, plays an important role in shear flow mechanotransduction in osteocytes.

  9. findings suggest that Zic1 controls the expansion of neuronal precursors by inhibiting the progression of neuronal differentiation

  10. The functions of Zic1 and Zic3 (show ZIC3 Proteins) may be essential to increasing neural cell numbers regionally in the medial telencephalon and to proper mediolateral patterning of the telencephalon.

ZIC1 Protein Profile

Protein Summary

This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene.

Gene names and symbols associated with ZIC1

  • Zic family member 1 (ZIC1)
  • Zic family member 1 (Zic1)
  • Zic family member 1 S homeolog (zic1.S)
  • zinc finger protein of the cerebellum 1 (Zic1)
  • opl protein
  • ZIC protein
  • ZNF201 protein

Protein level used designations for ZIC1

Zic family member 1 (odd-paired homolog, Drosophila) , Zinc finger protein of the cerebellum 1 , zinc finger protein 201 , zinc finger protein ZIC 1 , zic protein member 1 , zinc finger protein of the cerebellum 1 , XZic1 , ZIC-r1 , ZIC-related protein 1 , Zic family member 1 (odd-paired homolog) , Zic-related-1 , xlZic1 , xopl , odd-paired homolog

7545 Homo sapiens
64618 Rattus norvegicus
374103 Gallus gallus
399124 Xenopus laevis
22771 Mus musculus
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