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Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. Additionally we are shipping alpha 2 Macroglobulin Antibodies (302) and alpha 2 Macroglobulin Proteins (40) and many more products for this protein.
Showing 10 out of 88 products:
Human alpha 2 Macroglobulin ELISA Kit for Competition ELISA - ABIN2683306
Pineda-Salgado, Craig, Blank, Kessler: Expression of Panza, an alpha2-macroglobulin, in a restricted dorsal domain of the primitive gut in Xenopus laevis. in Gene expression patterns : GEP 2005
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Human alpha 2 Macroglobulin ELISA Kit for Sandwich ELISA - ABIN2683305
Tasnim, Zink: Cross talk between primary human renal tubular cells and endothelial cells in cocultures. in American journal of physiology. Renal physiology 2012
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Mouse (Murine) alpha 2 Macroglobulin ELISA Kit for Sandwich ELISA - ABIN2683308
Jensen, Humle Jørgensen, Datta, Sørensen: Significantly increased fractions of transformed to total alpha2-macroglobulin concentrations in plasma from patients with multiple sclerosis. in Biochimica et biophysica acta 2004
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Human alpha 2 Macroglobulin ELISA Kit for Sandwich ELISA - ABIN1874321
Lee, Cho, Kim, Kang, Yoo, Chang, Ko, Kim: Semi-quantitative measurement of a specific glycoform using a DNA-tagged antibody and lectin affinity chromatography for glyco-biomarker development. in Molecular & cellular proteomics : MCP 2015
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Human alpha 2 Macroglobulin ELISA Kit for Competition ELISA - ABIN366856
Xu, Zhang, Luo, Zhou, Wang, Fang, Li, Mu, Zhang, Zhang, Xie: Comparative proteomic analysis of plasma from major depressive patients: identification of proteins associated with lipid metabolism and immunoregulation. in The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2012
The blood coagulation pathway may be a key regulatory network pathway contributing to the allergic inflammatory response in AR patients. A2M, which is regulated by STAT3 (show STAT3 ELISA Kits), may be an important protein in the pathogenesis of allergic rhinitis in AR patients.
Proteomics study showed a strong association of FN1, A2M, C4BPA and CFB in molecular subtypes of breast cancer, in which, C4BPA and A2M demonstrated a potent signature in blood plasma and tissue samples of Luminal-B (LB) and Triple-negative (TN)subtypes in BC patients, respectively.
BBB (show ALMS1 ELISA Kits) disruption is present in ACS, and elevated levels of IL-6 (show IL6 ELISA Kits) and C3 in CSF (show CSF2 ELISA Kits) in diffuse NPSLE
Case Reports: inflammatory myofibroblastic tumors of the lung containing a chimeric A2M-ALK gene categorized as a specific type of inflammatory myofibroblastic tumor that develops exclusively in neonates and infants.
The plasma level of alpha2M was found positively correlated, while HCII (show SERPIND1 ELISA Kits) level was negatively correlated with higher vulnerability of carotid plaques. Both proteins were efficient in differentiating stable and vulnerable carotid plaques. These provide potential new targets for the research of carotid plaque vulnerability. Plasma alpha2M and HCII (show SERPIND1 ELISA Kits) may be potential biomarkers for evaluation of the vulnerability of carotid ...
Stabilizers during pasteurization improved alpha-2-macroglobulin (alpha2-M) activity by more than 300% points compared with the unstabilized control.
Data show that low that low globulin (GLB (show DCXR ELISA Kits)) levels were significantly associated with favorable survival, and low ALB (show ALB ELISA Kits) levels were associated with a significantly worse survival .
This work demonstrates that alpha2M*/CS-GRP78 (show HSPA5 ELISA Kits) acts as an upstream regulator of the PDK1 (show PDK1 ELISA Kits)/PLK1 (show PLK1 ELISA Kits) signaling axis to modulate c-MYC (show MYC ELISA Kits) transcription and its target genes, suggesting a therapeutic strategy for targeting c-MYC (show MYC ELISA Kits)-associated malignant progression.
Meta-analysis. Our data indicate that the rs669 (A/G) polymorphisms in A2M gene are associated with increased risk in Parkinson disease.
These data demonstrate that alpha2M* and LRP1 (show LRP1 ELISA Kits) modulate the BKCachannel in human myometrium and that BKCaand its immunomodulatory interacting partners regulate Ca(2 (show CA2 ELISA Kits)+)dynamics in hMSMCs during pregnancy.
To investigate the pharmacokinetics (PKs) and pharmacodynamics (PDs (show SLC26A4 ELISA Kits)) for ION-353382, an antisense oligonucleotide (ASO) targeting scavenger receptor class B type I (SRB1) mRNA, using alpha-2-macroglobulin (A2M), murinoglobulin double-knockout (DKO), and wild-type mice
A model is proposed that suggests that unlike proteases, which are irreversibly bound to activated alpha2M, hepcidin (show HAMP ELISA Kits) remains labile and available to down-regulate Fpn1 (show SLC40A1 ELISA Kits).
Data show that MAA-A2M adduct formation abrogated the binding of A2M bait region with TGF-beta1, trypsin, and elastase.
MMP9 (show MMP9 ELISA Kits) production promoted by the alpha(2)M*/LRP1 (show LRP1 ELISA Kits) interaction required the activation of both MAPK (show MAPK1 ELISA Kits)-ERK1/2 (show MAPK1/3 ELISA Kits) and NF-kappaB (show NFKB1 ELISA Kits) signaling pathways.
Alpha2 macroglobulin requires cyclic amp and signal transduction for cell growth
Increased Trypanosoma cruzi invasion and heart fibrosis associated with high transforming growth factor beta levels in mice deficient in alpha(2)-macroglobulin.
the 4622-base pair cDNA encodes a protein of 1473 AA with >70% sequence identity and all typical domains of other A2M-family members in humans and rodents
Data describe the role of the PI3-kinase (show PIK3CA ELISA Kits)/PDK (show PDK2 ELISA Kits)/Akt (show AKT1 ELISA Kits)/p70s6k (show RPS6KB1 ELISA Kits) signaling cascade in alpha 2-macroglobulin-induced cellular proliferation and the role of CREB (show CREB1 ELISA Kits) in these events.
review the A2M gene families of mice and humans, the predicted structural relationships between A2M and its pregnancy induced forms and the postulated roles for this gene family in normal pregnancy.
the inhibition of proteases on the surface of microorganisms by an ancestral alpha2M-like thiol ester protein may generate "arrays" of oligomannose glycans to which MBL or other lectins can bind
Data suggest that alpha(2)-macroglobulin from serum could significantly compensate for the impaired cumulus expansion of oocytes matured in serum.
Mutations in the promoter region and the 3'-untranslated region of the A2M gene are involved in the mastitis susceptibility in dairy cows.
We report here for the first time the direct isolation of Spp24 (show SPP2 ELISA Kits) covalently bound to alpha2-macroglobulins as a core complex (Spp24 (show SPP2 ELISA Kits)-alpha2M) from bovine calf serum.
Exon 29 c.3535A>T in the alpha-2-macroglobulin gene causing aberrant splice variants is associated with mastitis.
These results suggest the possible involvement of cathepsin E (show CTSE ELISA Kits) in disruption of the structural and functional integrity of alpha 2-macroglobulin in the endolysosome system.
Alpha2-macroglobulin is a substrate and an endogenous inhibitor for ADAMTS-4 (show ADAMTS4 ELISA Kits) and ADAMTS-5 (show ADAMTS5 ELISA Kits)
Amounts of alpha(2)-M receptor in granulosa cells were strongly inversely associated with concentrations of estradiol in dominant and subordinate follicles.
Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits.
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5
, alpha 2m
, alpha-2-macroglobulin b