anti-beta-1,4-N-Acetyl-Galactosaminyl Transferase 1 (B4GALNT1) Antibodies

GM2 and GD2 gangliosides are sialic acid-containing glycosphingolipids. Additionally we are shipping B4GALNT1 Proteins (7) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
B4GALNT1 2583 Q00973
B4GALNT1 14421 Q09200
B4GALNT1 64828 Q10468
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Top anti-B4GALNT1 Antibodies at antibodies-online.com

Showing 10 out of 61 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-B4GALNT1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:12500 Positive Control: Human kidney 100 μL 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-B4GALNT1 Antibody Titration:  0.2-1 ug/ml  Positive Control:  HepG2 cell lysate 100 μL 2 to 3 Days
$319.00
Details
Human Rabbit Un-conjugated IP, WB Western blot analysis of B4GALNT1 expression in MDAMB453 (A), A549 (B), K562 (C) whole cell lysates. 200 μL 13 to 14 Days
$487.50
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Human Rabbit Un-conjugated ELISA, WB 100 μL Available
$363.46
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Bat Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$581.17
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Bat Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$551.83
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Human Rabbit Un-conjugated ELISA, ICC, IF, WB ABIN6274909 staining HeLa by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25°C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody. Western blot analysis of extracts from HeLa cells using B4GALNT1 antibody.The lane on the left is treated with the antigen-specific peptide. 100 μL 11 to 12 Days
$390.77
Details
Human Mouse Un-conjugated ELISA, WB B4GALNT1 monoclonal antibody (M02), clone 5F9 Western Blot analysis of B4GALNT1 expression in HeLa . Detection limit for recombinant GST tagged B4GALNT1 is approximately 0.1ng/ml as a capture antibody. 100 μg 11 to 12 Days
$364.00
Details
Human Rabbit Un-conjugated WB Western blot analysis in mouse Neuro-2a cell line lysates (35ug/lane). Western blot analysis in MDA-MB453 cell line lysates (35ug/lane). 400 μL 2 to 3 Days
$515.63
Details
Human Rabbit Un-conjugated WB B4GALNT1 antibody used at 1 ug/ml to detect target protein. 50 μg 9 to 11 Days
$449.29
Details

Top referenced anti-B4GALNT1 Antibodies

  1. Cow (Bovine) Polyclonal B4GALNT1 Primary Antibody for WB - ABIN2782130 : Trilck, Peter, Zheng, Frank, Dobrenis, Mascher, Rolfs, Frech: Diversity of glycosphingolipid GM2 and cholesterol accumulation in NPC1 patient-specific iPSC-derived neurons. in Brain research 2016 (PubMed)

More Antibodies against B4GALNT1 Interaction Partners

Human beta-1,4-N-Acetyl-Galactosaminyl Transferase 1 (B4GALNT1) interaction partners

  1. High B4GALNT1 expression is associated with clear cell renal cell carcinoma metastasis.

  2. Sp1 or HDAC1 knock down increased GM2-synthase transcription, and butyrate-mediated activation of GM2-synthase mRNA expression in SK-RC-45 cells was accompanied by Sp1 and HDAC1 loss from the +38/+187 region. Taken together, we have identified an epigenetic mechanism for the de-repression of the GM2-synthase gene in RCC.

  3. Since the nineties, mice lacking genes for single glycosyltransferases involved in ganglioside biosynthesis, including ST3GAL5 and B4GALNT1, were created and studied. The resulting phenotypes were frequently mild or very mild, so double knock-out animals were created to effectively study the function of gangliosides

  4. Study analyzed enzyme activity and intracellular localization of the products of mutant cDNAs from eleven cases of hereditary spastic paraplegia with mutation in the coding region of B4GALNT1, and noted a lack of enzyme activity in a majority of them except two family cases. Then compared profiles of clinical findings of patients with hereditary spastic paraplegia and abnormal phenotypes of B4galnt-KO mice.

  5. Data suggest that ganglioside glycosyltransferases ST3GAL5, ST8SIA1, and B4GALNT1 are S-acylated at conserved cysteine residues located close to cytoplasmic border of their transmembrane domains; ST3Gal-II is acylated at conserved cysteine residue in N-terminal cytoplasmic tail; for B4GALNT1 and ST3Gal-II, dimer formation controls their S-acylation status.

  6. Novel B4GALNT1 mutations reported in two families with hereditary spastic paraplegia.

  7. The resukts of this study identified mutations in B4GALNT1 (GM2 synthase), encoding the enzyme that catalyzes the second step in complex ganglioside biosynthesis, as the cause of this neurodegenerative phenotype.

  8. Minimally disseminated disease in high risk retinoblastoma patients was detected using reverse transcriptase PCR for GD2 synthase mRNA in CSF.

  9. Molecular upstaging of GalNAc-T using rt-pcr was correlated with prognosis in melanoma patients

  10. GD2/GM2 is not a reliable biomarker in small cell lung carcinoma

  11. The expression of three messengers coding for SAT-1, SAT-2 and GalNAcT-1 in human samples of intestinal cancer and some cell lines (breast cancer and melanomas), was evaluated.

  12. Transmission disequilibrium test and case-control analysis did not detect an association of B4GALNT1 gene with T1DM.

Mouse (Murine) beta-1,4-N-Acetyl-Galactosaminyl Transferase 1 (B4GALNT1) interaction partners

  1. Study analyzed enzyme activity and intracellular localization of the products of mutant cDNAs from eleven cases of hereditary spastic paraplegia with mutation in the coding region of B4GALNT1, and noted a lack of enzyme activity in a majority of them except two family cases. Then compared profiles of clinical findings of patients with hereditary spastic paraplegia and abnormal phenotypes of B4galnt-KO mice.

  2. We used GM2/GD2 synthase (B4galnt1)-deficient mice to immunize by liposomes embedded with GD1alpha or acidic glycolipid fractions from brain of St3gal5-deficient mice. Specificities of established mAbs as analyzed by enzyme-linked immunosorbent assay and thin-layer chromatography-immunostaining were very high among various gangliosides.

  3. GM2 elevation is associated with activation of microglia and astrocytes in the injured developing brain, and GM2, GD2, or other downstream gangliosides may regulate astroglial responses in ethanol-induced neurodegeneration

  4. This study demonistrated that Ganglioside deficiency(B4galnt1 and ST8SIA1 knockout mice causes inflammation and neurodegeneration via the activation of complement system in the spinal cord.

  5. Galgt1 is required for presynaptic expression of the CT carbohydrate at the neuromuscular junction.

  6. Impaired hippocampal long-term potentiation and failure of learning in beta1,4-N-acetylgalactosaminyltransferase gene transgenic mice

  7. To define maturation of cortical neurons in mice lacking B4galnt1 we performed a morphological analysis of Golgi-Cox impregnated pyramidal neurons.

  8. The results of this study indicated that destruction of glycolipid-enriched microdomain is caused by ganglioside deficiency with gradual intensity depending on the degree of defects of their compositions.

  9. Our data indicate that it is highly unlikely that transmission failure at NMJs contributes to the progressive motor defects of aged GM2/GD2-synthase null-mutants.

  10. In GalNAc-T(-/-) mice, the number of degenerated axons was increased in the dorsal funiculus, tract of Lissauer, and dorsolateral funiculus of the cervical spinal cord as well as the dorsal funiculus and tract of Lissauer of the lumbar segment

  11. Increased 9-O-acetyl GD3, in addition to GM3 and GD3, may play an important role in the compensation for deleted complex gangliosides in the mutant mice.

B4GALNT1 Antigen Profile

Protein Summary

GM2 and GD2 gangliosides are sialic acid-containing glycosphingolipids. GalNAc-T is the enzyme involved in the biosynthesis of G(M2) and G(D2) glycosphingolipids. GalNAc-T catalyzes the transfer of GalNAc into G(M3) and G(D3) by a beta-1,4 linkage, resulting in the synthesis of G(M2) and G(D2), respectively. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with B4GALNT1

  • beta-1,4-N-acetyl-galactosaminyl transferase 1 L homeolog (b4galnt1.L) antibody
  • beta-1,4-N-acetyl-galactosaminyl transferase 1a (b4galnt1a) antibody
  • beta-1,4-N-acetyl-galactosaminyl transferase 1 (b4galnt1) antibody
  • Beta-1,4 N-acetylgalactosaminyltransferase 1 (b4gn1) antibody
  • beta-1,4-N-acetyl-galactosaminyltransferase 1 (B4GALNT1) antibody
  • beta-1,4-N-acetyl-galactosaminyl transferase 1 (B4galnt1) antibody
  • 4933429D13Rik antibody
  • B4GALNT1 antibody
  • Gal-NAc-T antibody
  • GALGT antibody
  • Galgt1 antibody
  • GalNAc-T antibody
  • GalNAcT antibody
  • Ggm-2 antibody
  • Ggm2 antibody
  • MGC53523 antibody
  • SPG26 antibody
  • zgc:158609 antibody

Protein level used designations for B4GALNT1

beta-1,4-N-acetyl-galactosaminyl transferase 1 , beta-1,4 N-acetylgalactosaminyltransferase 1 , Beta-1,4 N-acetylgalactosaminyltransferase 1 , beta-1,4 N-acetylgalactosaminyltransferase 1-like , (N-acetylneuraminyl)-galactosylglucosylceramide , GD2 synthase, GM2 synthase , GM2/GD2 synthase , UDP-Gal:betaGlcNAc beta-1,4-N-acetylgalactosaminyltransferase transferase 1 , UDP-N-acetyl-alpha-D-galactosamine:(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase (GalNAc-T) , beta1,4GalNAc-T , beta1-4GalNAc-T , UDP-N-acetyl-alpha-D-galactosamine:(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase , UDP-N-acetyl-alpha-D-galactosamine:(N-acetylneuraminyl)-galactosylglucosylceramide-beta-1, 4-N-acetylgalactosaminyltransferase , beta1,4GalNAC-T , beta-4N-acetylgalactosaminyltransferase

GENE ID SPECIES
379299 Xenopus laevis
558684 Danio rerio
100145208 Xenopus (Silurana) tropicalis
100306792 Salmo salar
100441953 Pongo abelii
100516440 Sus scrofa
2583 Homo sapiens
481129 Canis lupus familiaris
520159 Bos taurus
14421 Mus musculus
64828 Rattus norvegicus
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