anti-beta-Carotene 15,15'-Monooxygenase 1 (BCMO1) Antibodies

Vitamin A metabolism is important for vital processes such as vision, embryonic development, cell differentiation, and membrane and skin protection. Additionally we are shipping beta-Carotene 15,15'-Monooxygenase 1 Kits (11) and beta-Carotene 15,15'-Monooxygenase 1 Proteins (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
BCMO1 63857 Q9JJS6
BCMO1 53630 Q9HAY6
BCMO1 114106  
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Top anti-beta-Carotene 15,15'-Monooxygenase 1 Antibodies at antibodies-online.com

Showing 10 out of 36 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated WB Host: Rabbit Target Name: BCMO1 Sample Tissue: Human A549 Whole Cell Antibody Dilution: 1ug/ml 100 μL 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB 100 μL 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, WB BCMO1 Antibody (Center) western blot analysis in WiDr cell line lysates (35µg/lane).This demonstrates the BCMO1 antibody detected the BCMO1 protein (arrow). 0.4 mL 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated ICC, IHC, WB Figure. Western Blot; Sample: Recombinant protein. Figure.DAB staining on IHC-P. Samples: Human Tissue 100 μg 13 to 16 Days
$350.00
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Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of BCOR Antibody (Center S1122) in 293 cell line lysates (35ug/lane) Western blot analysis of BCOR Antibody (Center S1122) in mouse stomach tissue lysates (35ug/lane) 400 μL 2 to 3 Days
$515.63
Details
Human Rabbit Un-conjugated WB Western blot analysis in WiDr cell line lysates (35ug/lane). 400 μL 2 to 3 Days
$515.63
Details
Human Rabbit Un-conjugated WB   100 μL 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated WB   100 μL 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, WB   200 μL 11 to 16 Days
$658.43
Details
Human Rabbit PE ELISA, WB   200 μL 11 to 14 Days
$1,101.83
Details

More Antibodies against beta-Carotene 15,15'-Monooxygenase 1 Interaction Partners

Zebrafish beta-Carotene 15,15'-Monooxygenase 1 (BCMO1) interaction partners

  1. Data suggest that, for several developmental processes, retinoic acid generation depends on local de novo formation of retinal from provitamin A via the carotene oxygenase.

Cow (Bovine) beta-Carotene 15,15'-Monooxygenase 1 (BCMO1) interaction partners

  1. cloning and expression of beta-carotene-15,15'-oxygenase; expression shown in granulosa cells and the corpus luteum in the ovary and in germinal and interstitial cells in the testis

Mouse (Murine) beta-Carotene 15,15'-Monooxygenase 1 (BCMO1) interaction partners

  1. provided novel experimental evidence that BCO1 and BCO2 could play a significant role in maintaining normal hepatic lipid and cholesterol homeostasis, potentially through the regulation of the FXR/miR-34a/SIRT1 pathway

  2. This is the first demonstration that Bco1 disruption lowers murine circulating testosterone levels and thereby reduces prostatic androgen receptor signaling and prostatic cellular proliferation, further supporting the role of this protein in processes more diverse than carotenoid cleavage.

  3. tissue- and sex-specific effects of beta-carotene 15,15' oxygenase (BCO1) on retinoid and lipid metabolism

  4. BCO1 modulates heart metabolism and function, possibly by altering levels of cofactors required for the actions of nuclear hormone receptors

  5. Dietary wolfberry elevated the xanthophyll concentrations and enhanced expression of BCO2 and heat shock protein 60, activated AMPKalpha2, potentiated mitophagy and mitochondrial biogenesis and enhanced lipid oxidation and secretion in the liver of mice.

  6. Pleiotropic actions of Carotene-15,15'-monooxygenase and carotene-9',10'-monooxygenase supporting a strong role of these proteins in regulating tissue carotenoid accumulation as well as tomato carotenoid-independent regulation of lipid metabolism.

  7. in addition to cleaving beta-carotene to generate retinoids, CMOI serves an additional function(s) in retinoid and lipid metabolism and point to its role in the formation of specific lipids, possibly for use in nervous system tissue.

  8. a stepwise cleavage by BCO2 and BCO1 with APO10ol as an intermediate could provide a mechanism to tailor asymmetric carotenoids such as beta-cryptoxanthin for vitamin A production.

  9. beta-Carotene and its cleavage enzyme beta-carotene-15,15'-oxygenase (CMOI) affect retinoid metabolism in developing tissues.

  10. Gene expression in lungs is changed in the opposite direction by beta-carotene in male and female Bcmo1 -/- mice.

  11. In Bcmo1-deficient mice, Fzd6 AND Cthrc1 genes are upregulated.

  12. Knockout of the Bcmo1 gene results in an inflammatory response in female lung, which is suppressed by dietary beta-carotene.

  13. The role of conserved catalytic site aromatic residues in the catalytic mechanism of BCMO1 is consistent with the formation of a substrate carbocation intermediate and cation-pi stabilization.

  14. Transcriptional activation of the beta-carotene 15, 15'-monooxygenase gene by peroxisome proliferator-activated receptor (beta-carotene 15, 15'-monooxygenase).

  15. elevation of beta-carotene 15,15'-dioxygenase activity in hairless mice after UV exposure may be a response to reduction of the skin retinoid concentration

  16. the conserved histidines and Glu405 are absolutely required for the catalytic mechanism of BCMO1

  17. CMO1 is the key enzyme for vitamin A production in mice and alters lipid metabolism.

  18. Isx participates in the maintenance of vitamin A metabolism by regulating Bcmo1 expression in the intestine.

  19. CMO I KO mice fed low levels of vitamin A have altered lycopene biodistribution and isomer patterns and do not cleave beta-carotene to vitamin A at appreciable levels.

  20. Cadmium induces retinoic acid signaling by regulating retinoic acid metabolic gene (BCMO-1) expression

Human beta-Carotene 15,15'-Monooxygenase 1 (BCMO1) interaction partners

  1. Two BCO1 single nucleotide polymorphism (SNP) genotypes were significant predictors of the change in plasma lycopene associated with consumption of a tomato-soy beverage, with SNP effects differing in magnitude and direction, depending on the level of juice intake.

  2. In dyslipidemia patients, polymorphisms (rs12934922 and rs11646692) in the BCO1 gene may influence the development of coronary atherosclerosis.

  3. Single nucleotide polymorphism rs1501299 in the gene ADIPOQ (P=0.0010, OR=0.41, 95% C.I.:0.24-0.70) and rs7501331 in the gene BCMO1 (P=0.0106, OR=0.24, 95% C.I.:0.21-0.71), are significantly associated (the latter marginally significant) with the decrease of the risk of polycystic ovary syndrome.

  4. We did not observe associations of BCMO1 variants and lung cancer.

  5. Study reports a molecular mechanism by which glucocorticoid-induced PPARalpha expression negatively affects the activity of PPARgamma and downregulates BCO1 gene expression. Results explicate novel aspects of local glucocorticoid:retinoid interactions that may contribute to alveolar tissue remodeling in chronic lung diseases that affect children and, possibly, adults.

  6. study revealed circulating beta-carotene levels were significantly higher in rs6564851 GG homozygotes; daily intake of beta-cryptoxanthin was positively associated with circulating beta-carotene levels in female GG homozygotes of rs6564851 and the daily intake of alpha- and beta-carotenes, and beta-cryptoxanthin was significantly lower in female rs6564851 T allele carries than in female GG homozygotes

  7. Data suggest that beta-cryptoxanthin is a poorer substrate for BCMO1 than is beta-carotene; however, the comparatively high bioavailability of beta-cryptoxanthin from foods makes beta-cryptoxanthin-rich fruits good sources of vitamin A. [REVIEW]

  8. This study indicates that the competitive actions of HNF-1alpha and HNF-4alpha on their overlapping binding sites in the human BCMO1 gene promoter oppositely regulate BCMO1 gene expression in the human small intestine.

  9. Specific BCMO1 SNPs should be determined when assessing the effects of carotenoid supplementation on macular pigment and that their expression may be influenced by retinal disease.

  10. Incubation of beta-carotene and recombinant human BCMO1 in either H2(18)O-(16)O2 or H2(16)O-(18)O2 medium yields two retinal products both of which contain oxygen atoms originating solely from O2 gas. The results show that BCMO1 is a dioxygenase and not a monooxygenase as previously thought.

  11. Substrate specificity of purified recombinant human beta-carotene 15,15'-oxygenase (BCO1).

  12. BCMO1 SNP had a statistically significant association with HDL plasma levels.

  13. Individual responsiveness to dietary carotenoids was associated with genetic variants of the carotenoid metabolizing enzyme beta-carotene 15,15'-monooxygenase 1.

  14. a stepwise cleavage by BCO2 and BCO1 with APO10ol as an intermediate could provide a mechanism to tailor asymmetric carotenoids such as beta-cryptoxanthin for vitamin A production.

  15. Purified BCMO1 is a monomeric enzymatically active soluble protein that does not require cofactors and displays a turnover rate of about 8 molecules of beta,beta-carotene per second.

  16. CMO1 is expressed in human alveolar epithelial (A549) cells and converts beta-carotene into retinal and biologically active retinoic acids.

  17. Inhibition of BCMO1 expression is associated with increased invasiveness of colon cancer cells and increased expression of MMP7 and MMP28. beta-Carotene can upregulate BCMO1 and reverse these effects.

  18. genetic association study in US women of European descent: Data suggest that 2 SNP in BCMO1 (rs4889286; rs12934922) are associated with plasma carotenoid level (i.e., alpha-carotene, beta-carotene, lutein, zeaxanthin). (data from Nurses Health Study)

  19. investigated the effects of 4 identified SNP 5' upstream from the BCMO1 gene on beta-carotene conversion efficiency; found that three of the four intronic SNPs reduced the catalytic activity of BCMO1 in female volunteers

beta-Carotene 15,15'-Monooxygenase 1 (BCMO1) Antigen Profile

Protein Summary

Vitamin A metabolism is important for vital processes such as vision, embryonic development, cell differentiation, and membrane and skin protection. The protein encoded by this gene is a key enzyme in beta-carotene metabolism to vitamin A. It catalyzes the oxidative cleavage of beta,beta-carotene into two retinal molecules.

Gene names and symbols associated with BCMO1

  • beta-carotene oxygenase 1 (bco1) antibody
  • beta-carotene oxygenase 1 (BCO1) antibody
  • beta,beta-carotene 15,15'-dioxygenase (LOC100125495) antibody
  • beta-carotene 15,15'-monooxygenase 1 (BCMO1) antibody
  • beta-carotene oxygenase 1 (Bco1) antibody
  • b-diox antibody
  • BCDO antibody
  • BCDO1 antibody
  • BCMO antibody
  • bcmo1 antibody
  • BCO antibody
  • BCO1 antibody
  • bcox antibody
  • beta-CD antibody
  • betaCMOOX antibody
  • betaCO antibody
  • CMO1 antibody
  • Cmoi antibody

Protein level used designations for BCMO1

beta-carotene 15,15'-monooxygenase 1 , beta-carotene 15, 15-dioxygenase , beta-carotene 15, 15'-dioxygenase , beta-carotene 15, 15'-monooxygenase 1 , beta,beta-carotene 15,15'-monooxygenase , beta-carotene-15,15'-oxygenase , beta-carotene 15, 15-monooxygenase 1 , beta,beta-carotene 15,15'-monooxygenase-like , beta,beta-carotene 15,15'-dioxygenase , beta-carotene 15, 15'-dioxygenase 1 , beta-carotene 15,15' dioxygenase , beta-carotene cleavage enzyme , beta-carotene dioxygenase 1 , carotenoid-15,15'-oxygenase , beta-carotene 15 15'-dioxygenase , beta-carotene 15 15-dioxygenase , beta-carotene 15,15'-dioxygenase

GENE ID SPECIES
84039 Danio rerio
468043 Pan troglodytes
489695 Canis lupus familiaris
534696 Bos taurus
100031779 Monodelphis domestica
100069873 Equus caballus
100125495 Oryzias latipes
100192320 Sus scrofa
100228904 Taeniopygia guttata
100294509 Ovis aries
100393264 Callithrix jacchus
100483748 Ailuropoda melanoleuca
100603806 Nomascus leucogenys
63857 Mus musculus
53630 Homo sapiens
114106 Rattus norvegicus
395346 Gallus gallus
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