anti-beta-Site APP-Cleaving Enzyme 1 (BACE) Antibodies

Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Additionally we are shipping beta-Site APP-Cleaving Enzyme 1 Proteins (31) and beta-Site APP-Cleaving Enzyme 1 Kits (29) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
BACE 23621 P56817
BACE 23821 P56818
BACE 29392 P56819
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Top anti-beta-Site APP-Cleaving Enzyme 1 Antibodies at antibodies-online.com

Showing 10 out of 221 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated IF, IHC, WB WB Suggested Anti-BACE1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  Human Liver 100 μL 2 to 3 Days
$319.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-Bace1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:1562500 Positive Control: Mouse Heart 100 μL 2 to 3 Days
$319.00
Details
Human Rabbit Un-conjugated ELISA, IHC, WB ABIN6271175 at 1/200 staining Human liver cancer tissue sections by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. ABIN6271175 at 1/200 staining Mouse lung tissue sections by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. 100 μL 11 to 12 Days
$450.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated WB 100 μg 2 to 3 Days
$275.00
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti BACE1/ASP2 Polyclonal Antibody, Unconjugated (ABIN725705) at 1:200 followed by conjugation to the secondary antibody and DAB staining L1 rat brain lysates probed with Anti BACE1/ASP2 Polyclonal Antibody, Unconjugated (ABIN725705) at 1:200 overnight at 4 °C. Followed by conjugation to secondary antibody at 1:3000 for 90 min at 37 °C. Predicted band 51kD. Observed band size:51kD. 100 μL 3 to 7 Days
$329.45
Details
Human Rabbit Un-conjugated IF, IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human brain tissue, using BACE (Ab-498) Antibody. The picture on the right is treated with the synthesized peptide. Immunofluorescence analysis of HuvEc cells, using BACE (Ab-498) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IHC (p), WB IHC-P Image BACE1 antibody [N1C2] detects BACE1 protein at cytoplasm in Rat brain by immunohistochemical analysis. Sample: Paraffin-embedded Rat brain. BACE1 antibody [N1C2] , diluted at 1:500. IHC-P Image BACE1 antibody [N1C2] detects BACE1 protein at cytosol and membrane on mouse lung by immunohistochemical analysis. Sample: Paraffin-embedded mouse lung. BACE1 antibody [N1C2] , dilution: 1:500. 100 μL 3 to 4 Days
$466.18
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated WB 0.1 mg 6 to 8 Days
$687.50
Details

Top referenced anti-beta-Site APP-Cleaving Enzyme 1 Antibodies

  1. Human Polyclonal BACE Primary Antibody for IF (p), IHC (p) - ABIN725705 : Tian, Guo, Wu, Ma, Zhao: Minocycline Alleviates Sevoflurane-Induced Cognitive Impairment in Aged Rats. in Cellular and molecular neurobiology 2015 (PubMed)
    Show all 5 Pubmed References

  2. Human Monoclonal BACE Primary Antibody for CyTOF, FACS - ABIN4900525 : Cheng, He, Lee, Yao, Li, Shen: High activities of BACE1 in brains with mild cognitive impairment. in The American journal of pathology 2013 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal BACE Primary Antibody for WB - ABIN550289 : Vassar, Bennett, Babu-Khan, Kahn, Mendiaz, Denis, Teplow, Ross, Amarante, Loeloff, Luo, Fisher, Fuller, Edenson, Lile, Jarosinski, Biere, Curran, Burgess, Louis, Collins, Treanor, Rogers, Citron: Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. in Science (New York, N.Y.) 1999 (PubMed)
    Show all 3 Pubmed References

More Antibodies against beta-Site APP-Cleaving Enzyme 1 Interaction Partners

Human beta-Site APP-Cleaving Enzyme 1 (BACE) interaction partners

  1. show that neurons treated with conditioned media from HIV-infected macrophages have increased expression of beta-site amyloid precursor protein cleaving enzyme 1

  2. Inhibition of BACE1 has beneficial effects on senescence induced endothelial dysfunction. Reported findings may help to explain contributions of senescent cerebral microvascular endothelium to development of cerebral amyloid angiopathy and Alzheimer's disease (AD) pathology.

  3. In retinal pigment epithelial cells, BACE1 expression is regulated by SP1 and DNMT1 after photo-oxidation.

  4. the inhibition of APPswe-induced secretion of inflammatory cytokines and the suppression of NF-kappaB activation by miR-15b were validated...Our study suggests that miR-15b inhibits Abeta accumulation through targetting NF-kappaB signaling and BACE1 and serves as a potential molecular target for Alzheimer's disease (AD) therapy

  5. Study provide evidence that in patients with Alzheimer's disease altered BACE1 levels and activity impact the degradation of Abeta40 and Abeta42 into a common Abeta34 intermediate. Abeta34 CSF level is elevated in individuals with mild cognitive impairment who later progressed to dementia.

  6. Results show that BVR-A could prevent the CKI-mediated phosphorylation of BACE1, while the disruption of BVR-A kinase activity allows such phosphorylation. Increased BACE1 Ser phosphorylation is associated with increased Abeta levels in the parietal cortex.

  7. Overexpression of RTN3 T39 M in cultured neurons led to impaired axonal transport of BACE1. The variants found in this study are likely genetic modifiers for RTN3-mediated formation of neuritic plaques in Alzheimer's disease (AD).

  8. Study employed a targeted quantitative metabolomic methodology to measure brain metabolite changes occurring in PLB4 (neuron-specific human BACE1 knock-in) transgenic model. Carnosine and 8 phosphatidylcholine species were significantly decreased in 'young' PLB4 mouse brain. In 'old' PLB4 mice a total of 21 metabolites were perturbed. Within the PLB4 genotype there were a range of age-dependent increases in metabolites.

  9. Study delineates a novel CHOP-NF-kappaB signaling pathway that mediates palmitate-induced up-regulation of BACE1 expression and Abeta genesis.

  10. ORP150 and CHIP demonstrate antagonism under normal and stress conditions wherein they inversely regulate each other thus affecting BACE1 level.

  11. a gender dimorphism was observed in BACE1 gene expression in the patients in a way that the male patients manifested a statistically significant higher levels of BACE1 expression

  12. The BACE1 DISLL motif is phosphorylated and regulates endosomal trafficking, in primary neurons. Therefore, post-translational phosphorylation of DISLL enhances the exit of BACE1 from early endosomes, a pathway mediated by GGA1 and retromer, which is important in regulating Abeta production.

  13. BACE1 regulates the expression of insulin receptor in the liver

  14. Results indicated that the proinflammatory cytokine TNF-alpha impairs endothelial tight junctions and promotes monocyte-endothelial cell adhesion by upregulating beta-site amyloid precursor protein enzyme 1 expression through activating PKC signaling and sequentially cleaving alpha-2, 6-sialic acid transferase 1.

  15. Study did not detect any difference in peripheral expression of BACE1 and its naturally occurring antisense in epileptic patients and healthy subjects but a significant correlation between the transcript levels of these genes.

  16. BACE1 is predominantly SUMOylated at K501 residue, which escalates its protease activity and stability and subsequently increases Abeta production.

  17. Their anti-BACE1 and antimicrobial activity.

  18. Structural arrangement of BACE1-TM trimers and a mechanism for copper ion conduction that might also apply to other proteins involved in metal ion transport.

  19. Potentials for beneficial or consequential effects resulting from pharmacologic inhibition of BACE1 are reviewed in context of ongoing clinical trials testing the effect of BACE1 candidate inhibitor drugs in Alzheimer's disease populations.

  20. Measured plasma levels of beta-secretase 1 (BACE1) long non-coding RNA(LncRNA) in Alzheimer disease (AD) patients and healthy controls; found plasma BACE1 LncRNA to be a specific biomarker for AD.

Mouse (Murine) beta-Site APP-Cleaving Enzyme 1 (BACE) interaction partners

  1. beta-secretase beta-site APP cleaving enzyme 1 (BACE1) is a prerequisite for the generation of beta-amyloid peptide, a key pathogenic agent for Alzheimer's disease.

  2. ADAM10 interacts with BACE1 in mouse brain and primary neurons.ADAM10 enhances BACE1-mediated CHL1 proteolysis.

  3. defect in axonal organization correlated with reduced BACE1-mediated cleavage of the neural cell adhesion protein close homolog of L1 (CHL1), which has previously been associated with axon guidance.

  4. BACE1 promotes surface expression of Kv3.4 at mossy fiber terminals.

  5. The results of this study suggest that BACE1 is important for normal dentate gyrus network function.

  6. that NEAT1 worked as a regulating factor to promote the development of AD via modulating miR-124/BACE1 axis

  7. Concomitant gene silencing of BACE1, and consequent reduction in plaque load in the cerebral cortex and hippocampus (greater than 60%) in mice treated with TARBP-BTP:siRNA complex, led to improvement in spatial learning and memory.

  8. Study showed that administering vascular endothelial growth factor concurrently increased the expression of disintegrin and metalloproteinase domain-containing protein 10 and decreased the expression of beta-site APP cleaving enzyme 1, which contributes to the enhanced clearance of amyloid-beta in vivo.

  9. Pharmacological BACE1-inhibition selectively remodeled the neuronal surface glycoproteome, resulting in up to 7-fold increased abundance of the BACE1 substrates APP, APLP1, SEZ6, SEZ6L, CNTN2, and CHL1, whereas other substrates were not or only mildly affected.

  10. sustained and increasing BACE1 inhibition in adults can reverse amyloid deposition in an Alzheimer's disease mouse model.

  11. that BACE1 functions as the enzyme initiating the first cleavage step and serves a scaffold for amyloid- beta precursor protein and Presenilin 1 endocytosis.

  12. Study delineates a novel CHOP-NF-kappaB signaling pathway that mediates palmitate-induced up-regulation of BACE1 expression and Abeta genesis.

  13. BACE1 regulates adult hippocampal neurogenesis in mice.

  14. Results suggest that the colocalization of beta-site amyloid precursor protein cleaving enzyme-1 and amyloid precursor protein is increased in the presence of both amyloid beta and p75 in cortical neurons.

  15. Results show that NPC1 loss-of-function in a mouse model of Niemann-Pick type C disease leads to enhanced cleavage of BACE1 substrates Sez6 and Sez6L, in addition to APP, and that this effect most likely involves altered trafficking of BACE1 and of its substrates within the endolysosomal system. Efficacy of Sez6 cleavage by BACE1 may be spatiotemporally differently regulated in contrast to the cleavage of Sez6L.

  16. network analysis supports an intimate connection between immune response via NF-kappaB and BACE1 signaling through the NRG1/Akt1 pathway.

  17. BACE1 regulates the expression of insulin receptor in the liver

  18. Beta-site APP cleaving enzyme 1 knockout (Bace1-/-) mice and rats differed in body weight, spontaneous locomotor activity, and prepulse inhibition of startle.

  19. These results provide evidence for an emerging role of BAG-1M in the regulation of BACE1 expression and AD pathogenesis and that targeting the BAG-1M-NF-kappaB complex may provide a mechanism for inhibiting Abeta production and plaque formation.

  20. we have demonstrated that raised hypothalamic Abeta1-42, in conjunction with HFD, is sufficient to induce leptin resistance in the absence of increased inflammation, ER stress, SOCS3 and PTP1B. Thus, counteracting raised Bace1 activity associated with chronic HFD will play a critical protective role against metabolic disease

Zebrafish beta-Site APP-Cleaving Enzyme 1 (BACE) interaction partners

  1. bace1 mutants display hypomyelination in the peripheral nervous system and supernumerary neuromasts while in bace2 mutants the shape and migration of melanocytes is affected.

beta-Site APP-Cleaving Enzyme 1 (BACE) Antigen Profile

Protein Summary

Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene.

Gene names and symbols associated with BACE

  • beta-secretase 1 (BACE1) antibody
  • beta-site APP cleaving enzyme 1 (Bace1) antibody
  • beta-secretase 1 (Bace1) antibody
  • beta-site APP-cleaving enzyme 1 (bace1) antibody
  • ASP2 antibody
  • Bace antibody
  • BACE1 antibody
  • C76936 antibody
  • HSPC104 antibody
  • MGC145931 antibody
  • zgc:77409 antibody

Protein level used designations for BACE

APP beta-secretase , asp 2 , aspartyl protease 2 , beta-secretase 1 , beta-secretase 1 precursor variant 1 , beta-site APP cleaving enzyme 1 , beta-site amyloid beta A4 precursor protein-cleaving enzyme , memapsin-2 , membrane-associated aspartic protease 2 , transmembrane aspartic proteinase Asp2 , ASP2 , beta-site amyloid precursor protein cleaving enzyme 1 , beta-site APP cleaving enzyme , beta secretase 1 , beta-secretase 1 isoform A preproprotein , beta-secretase 1 isoform B preproprotein , beta-secretase 1 isoform C preproprotein , beta-site APP-cleaving enzyme 1 , beta-secretase 1-like

GENE ID SPECIES
23621 Homo sapiens
23821 Mus musculus
29392 Rattus norvegicus
419768 Gallus gallus
489390 Canis lupus familiaris
614333 Bos taurus
697694 Macaca mulatta
779940 Xenopus (Silurana) tropicalis
100071137 Equus caballus
100343442 Oryctolagus cuniculus
100459804 Pongo abelii
451573 Pan troglodytes
100025518 Monodelphis domestica
403005 Danio rerio
100135485 Cavia porcellus
100602656 Nomascus leucogenys
100511707 Sus scrofa
101119667 Ovis aries
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