anti-beta-Site APP-Cleaving Enzyme 1 (BACE) Antibodies

Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Additionally we are shipping beta-Site APP-Cleaving Enzyme 1 Kits (70) and beta-Site APP-Cleaving Enzyme 1 Proteins (33) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
BACE 23621 P56817
BACE 23821 P56818
BACE 29392 P56819
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Top anti-beta-Site APP-Cleaving Enzyme 1 Antibodies at antibodies-online.com

Showing 10 out of 228 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IF, IHC, WB WB Suggested Anti-BACE1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  Human Liver 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-Bace1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:1562500 Positive Control: Mouse Heart 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of anti-BACE1 Antibody (N-term) (ABIN392201) in mouse heart tissue lysates (35 µg/lane). BACE1(arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human brain tissue reacted with BACE1 antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$335.50
Details
Human Mouse Un-conjugated ELISA, FACS, ICC, WB Black line: Control Antigen (100 ng);Purple line: Antigen(10ng);Blue line: Antigen (50 ng);Red line: Antigen (100 ng); Dilution: 1/10000 Figure 1: Western blot analysis using BACE1 mAb against human BACE1 (AA: 112-324) recombinant protein. (Expected MW is 49.9 kDa) Dilution: 1/500 - 1/2000 100 μL Log in to see 8 to 11 Days
$561.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of anti-BACE Antibody (S498) (ABIN392200) in mouse cerebellum tissue lysates (35 µg/lane). BACE (arrow) was detected using the purified polyclonal antibody. All lanes : Anti-Phospho-BACE(S498) Antibody, ctrl at 1:1000 dilution Lane 1: SH-SY5Y whole cell lysate Lane 2: U-251 MG whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 56 kDa Blocking/Dilution buffer: 5% NFDM/TBST. Dilution: 1:1000 400 μL Log in to see 10 to 11 Days
$335.50
Details
Human Rabbit Un-conjugated IHC (p), WB The anti-Phospho-BACE-S498 Pab (ABIN389517) is used in Western blot to detect Phospho-BACE-S498 in mouse brain tissue lysate Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
$335.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 2 to 3 Days
$275.00
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti BACE1/ASP2 Polyclonal Antibody, Unconjugated (ABIN725705) at 1:200 followed by conjugation to the secondary antibody and DAB staining L1 rat brain lysates probed with Anti BACE1/ASP2 Polyclonal Antibody, Unconjugated (ABIN725705) at 1:200 overnight at 4 °C. Followed by conjugation to secondary antibody at 1:3000 for 90 min at 37 °C. Predicted band 51kD. Observed band size:51kD. 100 μL Log in to see 3 to 7 Days
$318.45
Details
Human Rabbit Un-conjugated IF, IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human brain tissue, using BACE (Ab-498) Antibody. The picture on the right is treated with the synthesized peptide. Immunofluorescence analysis of HuvEc cells, using BACE (Ab-498) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details

Top referenced anti-beta-Site APP-Cleaving Enzyme 1 Antibodies

  1. Human Polyclonal BACE Primary Antibody for IF (p), IHC (p) - ABIN725705 : Tian, Guo, Wu, Ma, Zhao: Minocycline Alleviates Sevoflurane-Induced Cognitive Impairment in Aged Rats. in Cellular and molecular neurobiology 2015 (PubMed)
    Show all 5 Pubmed References

  2. Human Monoclonal BACE Primary Antibody for CyTOF, FACS - ABIN4900525 : Cheng, He, Lee, Yao, Li, Shen: High activities of BACE1 in brains with mild cognitive impairment. in The American journal of pathology 2013 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal BACE Primary Antibody for IHC (p), WB - ABIN392201 : Xie, Guo: PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein. in The Journal of biological chemistry 2005 (PubMed)
    Show all 5 Pubmed References

  4. Human Polyclonal BACE Primary Antibody for WB - ABIN550289 : Vassar, Bennett, Babu-Khan, Kahn, Mendiaz, Denis, Teplow, Ross, Amarante, Loeloff, Luo, Fisher, Fuller, Edenson, Lile, Jarosinski, Biere, Curran, Burgess, Louis, Collins, Treanor, Rogers, Citron: Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. in Science (New York, N.Y.) 1999 (PubMed)
    Show all 3 Pubmed References

More Antibodies against beta-Site APP-Cleaving Enzyme 1 Interaction Partners

Human beta-Site APP-Cleaving Enzyme 1 (BACE) interaction partners

  1. Their anti-BACE1 and antimicrobial activity.

  2. Structural arrangement of BACE1-TM trimers and a mechanism for copper ion conduction that might also apply to other proteins involved in metal ion transport.

  3. Potentials for beneficial or consequential effects resulting from pharmacologic inhibition of BACE1 are reviewed in context of ongoing clinical trials testing the effect of BACE1 candidate inhibitor drugs in Alzheimer's disease populations.

  4. Measured plasma levels of beta-secretase 1 (BACE1) long non-coding RNA(LncRNA) in Alzheimer disease (AD) patients and healthy controls; found plasma BACE1 LncRNA to be a specific biomarker for AD.

  5. Amyloid beta oligomers modulate BACE1 through an XBP-1 (show XBP1 Antibodies)-dependent pathway involving HRD1 (show SYVN1 Antibodies).

  6. Polymethoxyflavones isolated from citrus peels might be considered as promising BACE1 inhibitory agents that could lower Abeta (show APP Antibodies) production in Alzheimer disease.

  7. In BACE1 transgenic (Tg) mice, axonal regeneration was reduced when compared with wilde-type (WT) littermates at 3 and 10 days post crush. Study observed a decreased percentage of innervated neuromuscular junctions at 15 days post crush; and a functional recovery delay in the transgenic mice as it took 8 weeks for the compound muscle action potential amplitudes of Tg mice to begin to reach similar values comparable to WT.

  8. Our study demonstrated there may exist an association between BACE1 rs535860 polymorphism and focal seizures in Chinese Han males.

  9. This study shown that the protein expression of BACE1 is downregulated by chronic treatment with donepezil. This effect may be interpreted as evidence of disease modification.

  10. Endosome-to-TGN (show TG Antibodies) trafficking of BACE1 is regulated by Par3 (show F2RL2 Antibodies) and aPKC. This is a mechanism in pathogenesis of Alzheimer disease.

Mouse (Murine) beta-Site APP-Cleaving Enzyme 1 (BACE) interaction partners

  1. Amyloid beta oligomers modulate BACE1 through an XBP-1 (show XBP1 Antibodies)-dependent pathway involving HRD1 (show SYVN1 Antibodies).

  2. BACE1 deficiency develops abnormal clusters of immature neurons, forming doublecortin (show DCX Antibodies)-positive neuroblasts, in the developing dentate gyrus, mainly in the subpial zone.

  3. Increased TNFR1 (show TNFRSF1A Antibodies) expression and signaling in injured peripheral nerves of mice with reduced BACE1 activity

  4. We aimed to explore the potential therapeutic effect of PGC-1alpha by generating a lentiviral vector to express human PGC-1alpha and target it by stereotaxic delivery to hippocampus and cortex of APP23 transgenic mice . Four months after hPGC-1alpha injection, mice showed improved spatial and recognition memory concomitant with a significant reduction in Abeta (show APP Antibodies) deposition, associated with a decrease in BACE1 expression

  5. that BACE1 deficiency enhances proliferation of Schwann cell due to the elevated Jag1 (show JAG1 Antibodies)/Delta1-Notch (show NOTCH1 Antibodies) signaling

  6. the synaptic localization of APP (show APP Antibodies), ADAM10 (show ADAM10 Antibodies), and BACE1 in the mouse cerebral cortex, was examined.

  7. study demonstrates that SEZ6 and SEZ6L (show SEZ6L Antibodies) are physiological BACE1 substrates in the murine brain and suggests that sSEZ6 and sSEZ6L levels in CSF (show CSF2 Antibodies) are suitable markers to monitor BACE1 inhibition in mice

  8. Chronic variable stress led to increased Bace1 expression in the hippocampus of young adult mice and the hippocampus, prefrontal cortex and amygdala of aged mice. The increased expression of Bace1 was associated with decreased methylation of several CpGs in the Bace1 promoter region.

  9. Results indicate that SNX4 (show SNX4 Antibodies)-mediated regulation of the steady-state levels and trafficking of BACE1, as well as the subsequent increase in BACE1-mediated cleavage, may be relevant to Alzheimer's disease progression.

  10. In conclusion, glucocorticoid couples mGR (show GRHL1 Antibodies) with Galphas (show GNAS Antibodies) and triggers cAMP-PKA-CREB (show CREB1 Antibodies) axis dependent on the lipid raft to stimulate BACE1 upregulation and Abeta (show APP Antibodies) generation.SIGNIFICANCE STATEMENT Patients with Alzheimer's disease (AD) have been growing sharply and stress is considered as the major environment factor of AD.

Zebrafish beta-Site APP-Cleaving Enzyme 1 (BACE) interaction partners

  1. bace1 mutants display hypomyelination in the peripheral nervous system and supernumerary neuromasts while in bace2 (show BACE2 Antibodies) mutants the shape and migration of melanocytes is affected.

beta-Site APP-Cleaving Enzyme 1 (BACE) Antigen Profile

Protein Summary

Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene.

Gene names and symbols associated with BACE

  • beta-secretase 1 (BACE1) antibody
  • beta-site APP cleaving enzyme 1 (Bace1) antibody
  • beta-secretase 1 (Bace1) antibody
  • beta-site APP-cleaving enzyme 1 (bace1) antibody
  • ASP2 antibody
  • Bace antibody
  • BACE1 antibody
  • C76936 antibody
  • HSPC104 antibody
  • MGC145931 antibody
  • zgc:77409 antibody

Protein level used designations for BACE

APP beta-secretase , asp 2 , aspartyl protease 2 , beta-secretase 1 , beta-secretase 1 precursor variant 1 , beta-site APP cleaving enzyme 1 , beta-site amyloid beta A4 precursor protein-cleaving enzyme , memapsin-2 , membrane-associated aspartic protease 2 , transmembrane aspartic proteinase Asp2 , ASP2 , beta-site amyloid precursor protein cleaving enzyme 1 , beta-site APP cleaving enzyme , beta secretase 1 , beta-secretase 1 isoform A preproprotein , beta-secretase 1 isoform B preproprotein , beta-secretase 1 isoform C preproprotein , beta-site APP-cleaving enzyme 1 , beta-secretase 1-like

GENE ID SPECIES
23621 Homo sapiens
23821 Mus musculus
29392 Rattus norvegicus
419768 Gallus gallus
489390 Canis lupus familiaris
614333 Bos taurus
697694 Macaca mulatta
779940 Xenopus (Silurana) tropicalis
100071137 Equus caballus
100343442 Oryctolagus cuniculus
100459804 Pongo abelii
451573 Pan troglodytes
100025518 Monodelphis domestica
403005 Danio rerio
100135485 Cavia porcellus
100602656 Nomascus leucogenys
100511707 Sus scrofa
101119667 Ovis aries
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