beta-Site APP-Cleaving Enzyme 1 (BACE) ELISA Kits

Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Additionally we are shipping beta-Site APP-Cleaving Enzyme 1 Antibodies (230) and beta-Site APP-Cleaving Enzyme 1 Proteins (33) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
BACE 23621 P56817
BACE 23821 P56818
BACE 29392 P56819
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Top beta-Site APP-Cleaving Enzyme 1 ELISA Kits at antibodies-online.com

Showing 10 out of 71 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.78 pg/mL 3.12-200 pg/mL Typical standard curve 96 Tests Log in to see 13 to 16 Days
$1,026.67
Details
Mouse 12.1 pg/mL 31.2 pg/mL - 2000 pg/mL 96 Tests Log in to see 13 to 16 Days
$682.11
Details
Rat 6.7 pg/mL 15.62 pg/mL - 1000 pg/mL 96 Tests Log in to see 13 to 16 Days
$720.00
Details
Human 1.0 ng/mL 1.0-250 ng/mL 96 Tests Log in to see 2 to 3 Days
$562.10
Details
Guinea Pig 1.0 pg/mL 50-1000 pg/mL   96 Tests Log in to see 15 to 18 Days
$707.14
Details
Rabbit 1.0 pg/mL 50-1000 pg/mL   96 Tests Log in to see 15 to 18 Days
$707.14
Details
Chicken 0.938 ng/mL 1.563-100 ng/mL   96 Tests Log in to see 12 to 14 Days
$715.00
Details
Pig 0.375 ng/mL 0.625-40 ng/mL   96 Tests Log in to see 12 to 14 Days
$715.00
Details
Monkey 0.375 ng/mL 0.625-40 ng/mL   96 Tests Log in to see 12 to 14 Days
$715.00
Details
Dog 1.0 pg/mL 50-1000 pg/mL   96 Tests Log in to see 15 to 18 Days
$707.14
Details

Top referenced beta-Site APP-Cleaving Enzyme 1 ELISA Kits

  1. ABIN1882408 : Lee, Park, Han: Effect of mycelial extract of Clavicorona pyxidata on the production of amyloid beta-peptide and the inhibition of endogenous beta-secretase activity in vitro. in Journal of microbiology (Seoul, Korea) 2007 (PubMed)
    Show all 3 Pubmed References

  2. Human BACE ELISA Kit for Sandwich ELISA - ABIN1110850 : Johnson, Drugan, Miller, Evans: 38 in 1991 (PubMed)
    Show all 2 Pubmed References

  3. Human BACE ELISA Kit for Sandwich ELISA - ABIN365021 : Qian, Ding, Cheng, Zhu, Zhao, Jin, Guan, Zhang, Chen, Xu: Early biomarkers for post-stroke cognitive impairment. in Journal of neurology 2012 (PubMed)

  4. Mouse (Murine) BACE ELISA Kit for Sandwich ELISA - ABIN424458 : Che, Zhou, Zhang, Zhang, Ding, Yanagita, Xu, Xue, Wang: Comparative study of the effects of phosphatidylcholine rich in DHA and EPA on Alzheimer's disease and the possible mechanisms in CHO-APP/PS1 cells and SAMP8 mice. in Food & function 2017 (PubMed)

More ELISA Kits for beta-Site APP-Cleaving Enzyme 1 Interaction Partners

Human beta-Site APP-Cleaving Enzyme 1 (BACE) interaction partners

  1. Results indicated that the proinflammatory cytokine TNF-alpha impairs endothelial tight junctions and promotes monocyte-endothelial cell adhesion by upregulating beta-site amyloid precursor protein enzyme 1 expression through activating PKC signaling and sequentially cleaving alpha-2, 6-sialic acid transferase 1.

  2. Study did not detect any difference in peripheral expression of BACE1 and its naturally occurring antisense in epileptic patients and healthy subjects but a significant correlation between the transcript levels of these genes.

  3. BACE1 is predominantly SUMOylated at K501 residue, which escalates its protease activity and stability and subsequently increases Abeta (show APP ELISA Kits) production.

  4. Their anti-BACE1 and antimicrobial activity.

  5. Structural arrangement of BACE1-TM trimers and a mechanism for copper ion conduction that might also apply to other proteins involved in metal ion transport.

  6. Potentials for beneficial or consequential effects resulting from pharmacologic inhibition of BACE1 are reviewed in context of ongoing clinical trials testing the effect of BACE1 candidate inhibitor drugs in Alzheimer's disease populations.

  7. Measured plasma levels of beta-secretase 1 (BACE1) long non-coding RNA(LncRNA) in Alzheimer disease (AD) patients and healthy controls; found plasma BACE1 LncRNA to be a specific biomarker for AD.

  8. Amyloid beta oligomers modulate BACE1 through an XBP-1 (show XBP1 ELISA Kits)-dependent pathway involving HRD1 (show SYVN1 ELISA Kits).

  9. Polymethoxyflavones isolated from citrus peels might be considered as promising BACE1 inhibitory agents that could lower Abeta (show APP ELISA Kits) production in Alzheimer disease.

  10. In BACE1 transgenic (Tg) mice, axonal regeneration was reduced when compared with wilde-type (WT) littermates at 3 and 10 days post crush. Study observed a decreased percentage of innervated neuromuscular junctions at 15 days post crush; and a functional recovery delay in the transgenic mice as it took 8 weeks for the compound muscle action potential amplitudes of Tg mice to begin to reach similar values comparable to WT.

Mouse (Murine) beta-Site APP-Cleaving Enzyme 1 (BACE) interaction partners

  1. we have demonstrated that raised hypothalamic Abeta1-42, in conjunction with HFD, is sufficient to induce leptin (show LEP ELISA Kits) resistance in the absence of increased inflammation, ER stress, SOCS3 (show SOCS3 ELISA Kits) and PTP1B (show PTPN1 ELISA Kits). Thus, counteracting raised Bace1 activity associated with chronic HFD will play a critical protective role against metabolic disease

  2. Amyloid beta oligomers modulate BACE1 through an XBP-1 (show XBP1 ELISA Kits)-dependent pathway involving HRD1 (show SYVN1 ELISA Kits).

  3. BACE1 deficiency develops abnormal clusters of immature neurons, forming doublecortin (show DCX ELISA Kits)-positive neuroblasts, in the developing dentate gyrus, mainly in the subpial zone.

  4. Increased TNFR1 (show TNFRSF1A ELISA Kits) expression and signaling in injured peripheral nerves of mice with reduced BACE1 activity

  5. We aimed to explore the potential therapeutic effect of PGC-1alpha (show PPARGC1A ELISA Kits) by generating a lentiviral vector to express human PGC-1alpha (show PPARGC1A ELISA Kits) and target it by stereotaxic delivery to hippocampus and cortex of APP23 transgenic mice . Four months after hPGC-1alpha injection, mice showed improved spatial and recognition memory concomitant with a significant reduction in Abeta (show APP ELISA Kits) deposition, associated with a decrease in BACE1 expression

  6. that BACE1 deficiency enhances proliferation of Schwann cell due to the elevated Jag1 (show JAG1 ELISA Kits)/Delta1-Notch (show NOTCH1 ELISA Kits) signaling

  7. the synaptic localization of APP (show APP ELISA Kits), ADAM10 (show ADAM10 ELISA Kits), and BACE1 in the mouse cerebral cortex, was examined.

  8. study demonstrates that SEZ6 and SEZ6L are physiological BACE1 substrates in the murine brain and suggests that sSEZ6 and sSEZ6L levels in CSF (show CSF2 ELISA Kits) are suitable markers to monitor BACE1 inhibition in mice

  9. Chronic variable stress led to increased Bace1 expression in the hippocampus of young adult mice and the hippocampus, prefrontal cortex and amygdala of aged mice. The increased expression of Bace1 was associated with decreased methylation of several CpGs in the Bace1 promoter region.

  10. Results indicate that SNX4-mediated regulation of the steady-state levels and trafficking of BACE1, as well as the subsequent increase in BACE1-mediated cleavage, may be relevant to Alzheimer's disease progression.

Zebrafish beta-Site APP-Cleaving Enzyme 1 (BACE) interaction partners

  1. bace1 mutants display hypomyelination in the peripheral nervous system and supernumerary neuromasts while in bace2 (show BACE2 ELISA Kits) mutants the shape and migration of melanocytes is affected.

beta-Site APP-Cleaving Enzyme 1 (BACE) Antigen Profile

Antigen Summary

Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene.

Gene names and symbols associated with BACE

  • beta-secretase 1 (BACE1) antibody
  • beta-site APP cleaving enzyme 1 (Bace1) antibody
  • beta-secretase 1 (Bace1) antibody
  • beta-site APP-cleaving enzyme 1 (bace1) antibody
  • ASP2 antibody
  • Bace antibody
  • BACE1 antibody
  • C76936 antibody
  • HSPC104 antibody
  • MGC145931 antibody
  • zgc:77409 antibody

Protein level used designations for BACE

APP beta-secretase , asp 2 , aspartyl protease 2 , beta-secretase 1 , beta-secretase 1 precursor variant 1 , beta-site APP cleaving enzyme 1 , beta-site amyloid beta A4 precursor protein-cleaving enzyme , memapsin-2 , membrane-associated aspartic protease 2 , transmembrane aspartic proteinase Asp2 , ASP2 , beta-site amyloid precursor protein cleaving enzyme 1 , beta-site APP cleaving enzyme , beta secretase 1 , beta-secretase 1 isoform A preproprotein , beta-secretase 1 isoform B preproprotein , beta-secretase 1 isoform C preproprotein , beta-site APP-cleaving enzyme 1 , beta-secretase 1-like

GENE ID SPECIES
23621 Homo sapiens
23821 Mus musculus
29392 Rattus norvegicus
419768 Gallus gallus
489390 Canis lupus familiaris
614333 Bos taurus
697694 Macaca mulatta
779940 Xenopus (Silurana) tropicalis
100071137 Equus caballus
100343442 Oryctolagus cuniculus
100459804 Pongo abelii
451573 Pan troglodytes
100025518 Monodelphis domestica
403005 Danio rerio
100135485 Cavia porcellus
100602656 Nomascus leucogenys
100511707 Sus scrofa
101119667 Ovis aries
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