gamma-aminobutyric Acid (GABA) A Receptor, alpha 2 Proteins (GABRA2)

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Additionally we are shipping GABRA2 Antibodies (111) and GABRA2 Kits (24) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GABRA2 2555 P47869
Rat GABRA2 GABRA2 289606  
GABRA2 14395 P26048
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Top GABRA2 Proteins at antibodies-online.com

Showing 7 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$5,262.31
Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,370.21
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Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,370.21
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
$7,493.38
Details
Escherichia coli (E. coli) Human Un-conjugated SDS-PAGE analysis of Human gABRA2 Protein. 100 μg Log in to see 11 to 18 Days
$639.61
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Wheat germ Human Un-conjugated   10 μg Log in to see 11 to 12 Days
$564.00
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Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 11 to 18 Days
$582.75
Details

GABRA2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
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Mouse (Murine) ,
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More Proteins for gamma-aminobutyric Acid (GABA) A Receptor, alpha 2 (GABRA2) Interaction Partners

Rhesus Monkey gamma-aminobutyric Acid (GABA) A Receptor, alpha 2 (GABRA2) interaction partners

  1. the developmental shift in GABA(A) receptor alpha subunit expression continues through adolescence in primate dorsolateral prefrontal cortex

Human gamma-aminobutyric Acid (GABA) A Receptor, alpha 2 (GABRA2) interaction partners

  1. GABRA2 rs279858-linked variants might be a key genetic modulator for heroin vulnerability by affecting the connections of reward network and cognition. The role of the reward network connections that mediates the effects of GABRA2 rs279858 on cognition would be disrupted by heroin addiction.

  2. Findings suggest GABRA2 variation influences drug-seeking behavior through both alcohol-related and alcohol-independent pathways.

  3. rs505474, rs1398175, and rs4868029 in the GABRA2, GABRA4, and GABRP genes, respectively, allele frequencies were significantly different between patients and controls.Four haplotypes were significantly associated with Bipolar Disorder TA and AG for rs3815762 and rs4868029 in GABRP, GG for rs11636988 and rs8024256 in GABRB3 and GAGG for rs2197414, rs4921195, rs13188991, and rs11956731 in GABRA6.

  4. The results of the present study suggest that the GABRA2 genotype interacts with stress in young people with impact on the development of alcohol use and aggressive behaviour.

  5. GxE interaction: GABRA2 x Positive Peer Involvement on adolescent behavior.

  6. Association between GABRA2 and Alcohol Dependence was essentially limited to individuals with co-occurring Drug Dependence. The GABAA receptor is a heteropentamer so there are multiple potential variants in either GABRA2 or other receptor subunits which might associate with the phenotypes of interest and there is also a high degree of linkage disequilibrium across the region.

  7. GABA alpha2 and/or alpha3 receptor subtypes are involved in GABAergic modulation of prolactin secretion.

  8. An uncorrected exploratory analysis revealed associations between GABBR2, GABRA2 and DRD2 variants with transcranial magnetic stimulation measures of corticospinal excitability and cortical inhibition in Huntington's disease, as well as with age at onset.

  9. Our study findings showed COMT polymorphism conferring risk and GABRA1 and GABRA2 polymorphism as a protective genotype for Indian male with alcohol dependence (AD)

  10. SNP rs279858 mediates alcohol drinking in alcohol dependent individuals

  11. The alpha2 gradually increased during development, showing some layer specificity in the cerebellar cortex.

  12. parental externalizing was associated with more life events, and the association between life events and subsequent adolescent externalizing varied as a function of GABRA2 genotype (p

  13. A GABRA2 x Parental Monitoring effect on externalizing behavior trajectory was observed, such that A-carriers were largely unaffected by parental monitoring, whereas trajectory for those with the GG genotype was affected by parental monitoring.

  14. GABRA2 SNPs directly predicted adolescent alcohol problems.

  15. Alcohol dependence-associated variation in GABRA2 is associated with differential expression of the entire cluster of GABAA subunit genes on chromosome 4p12 in neural stem cells.

  16. Recent drinking history (p = 0.01), and recent drinking history x genotype interaction (p = 0.01) were significantly associated with acute adaptation of the subjective responses to alcohol for the GABRA2 SNP rs279858.

  17. The results of this study support a growing body of evidence linking GABAA receptors with the development of alcohol tolerance, dependence and withdrawal symptoms

  18. GABRA2 is significantly associated with rule breaking in mid- to late adolescence, but not substance abuse symptomatology across adolescence.

  19. GABRA2 genetic variants play a role in antipsychotic-associated weight gain.

  20. The results suggest that SNP variation in the GABRA2 gene leads to higer risk of increased drunkenness in the period adolescence to you adulthood

Mouse (Murine) gamma-aminobutyric Acid (GABA) A Receptor, alpha 2 (GABRA2) interaction partners

  1. Gabra2-1 mice display spontaneous seizures during development, accompanied by early mortality

  2. At a lower concentration of fluoxetine and its active metabolite norfluoxetine (that is in the therapeutic range), study observed anxiogenic- and depressive-like actions in alpha2 knock-out mice, but not in alpha2+/+ mice, suggesting that in 129x1/SvJ mice a decrease in alpha2-containing GABAARs promotes an increased sensitivity to the prodepressant-like effects of chronic fluoxetine treatment.

  3. Findings suggest that ovarian cycle-related progesterone and neurosteroids regulate alpha2-GABA-A receptor expression in the hippocampus via a non-progesterone receptor pathway, which may be relevant to menstrual-cycle related brain conditions.

  4. Results show that the expression levels of Gabra2, as well as of GABA receptor-mediated inhibitory neurotransmission, are reduced in Shank2 e6-7, but not in e7 KO mice compared with their own wild type littermates. Shank2 e6-7 KO mice treated with allosteric modulator for the GABAA receptor reverses spatial memory deficits, indicating that reduced inhibitory neurotransmission may cause memory deficits in Shank2.

  5. role for: (i) H101 in species-typical binge-like drinking, (ii) Q241 in escalated chronic drinking, and (iii) S270 and/or L277 in the development of forced abstinence-associated social deficits

  6. Pharmological manipulation by clobazam, a common anticonvulsant with preferential affinity for the GABRA2 receptor, revealed dose-dependent protection against hyperthermia-induced seizures in Scn1a+/- mice. These findings support Gabra2 as a genetic modifier of the Scn1a+/- mouse model of Dravet syndrome.

  7. Results indicate that 174 proteins were associated with gamma-aminobutyric acid receptor subunit alpha 2 (pHalpha2).

  8. whilst not directly involved in reward perception, the alpha2- subunit may be involved in modulating the "energising" aspect of cocaine's effects on reward-seeking.

  9. Wild-type and mutant mice have similar baseline nociceptive sensitivities and develop similar hyperalgesia specifically targeting alpha2-GABAA receptors which exert their antihyperalgesic effect through enhanced spinal nociceptive control.

  10. GABRA2 subunit expression in hippocampus modulates neurogenesis through nuclear factor of activated T cell (NFATc)4 activity.

  11. Disrupting the clustering of GABAA receptor alpha2 subunits in the frontal cortex leads to reduced gamma-power and cognitive deficits.

  12. Recovery of function following alcoholic intoxication is regulated by Gabra2 and Gabra3 receptor subunits.

  13. These findings suggest that alpha2-containing GABA(A) receptors expressed in the CA3 region provide the inhibition that controls hippocampal rhythm during cholinergically induced oscillations

  14. The findings of this study implicated alpha2 and alpha3 subunit containing GABA(A) receptors as key mediators of the reward-related effects of benzodiazepines

  15. The results of this study emphasize the critical role of GABAergic synaptic signaling for structural maturation of adult-born GCs and formation of glutamatergic synapses.

  16. Data suggest that the availability of distinct GABA(A) R subtypes (Gabra2, -4, and Gabrd) provides a molecular mechanism endowing spatiotemporal specificity to GABAergic control of neuronal maturation in adult brain.

  17. Data show that L. rhamnosus (JB-1) reduced GABA(Aalpha2) mRNA expression in the prefrontal cortex and amygdala, but increased GABA(Aalpha2) in the hippocampus.

  18. presynaptic GABAA receptors residing on the axons or terminals of primary nociceptors play a significant role in spinal pain control.

  19. Arc and Fos, increased about 250% in the alpha2 mutants, Behavioral effects (loss of righting reflex, rotarod) of flurazepam and pentobarbital were not different between alpha2 mutants and wild-type, but they were enhanced for alpha1 knock-in mice.

  20. results show that alpha 2-containing GABAA receptors represent a specific molecular substrate that can regulate depressive-like states.

GABRA2 Protein Profile

Protein Summary

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Alternatively spliced transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with GABRA2

  • gamma-aminobutyric acid type A receptor alpha2 subunit (GABRA2)
  • gamma-aminobutyric acid type A receptor alpha1 subunit (GABRA1)
  • gamma-aminobutyric acid (GABA) A receptor, alpha 2 (gabra2)
  • gamma-aminobutyric acid type A receptor alpha2 subunit (Gabra2)
  • gamma-aminobutyric acid (GABA) A receptor, alpha 2 S homeolog (gabra2.S)
  • gamma-aminobutyric acid (GABA) A receptor, alpha 2 (GABRA2)
  • gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2 (Gabra2)
  • C630048P16Rik protein
  • Gabra-2 protein

Protein level used designations for GABRA2

GABA(A) receptor subunit alpha-2 , gamma-aminobutyric acid receptor subunit alpha-2 , GABA-A receptor alpha-1 subunit , gamma-aminobutyric acid (GABA) A receptor, alpha 2 , gamma-aminobutyric acid A receptor alpha 2 , gamma-aminobutyric acid A receptor, alpha 2 precursor-like , GABA(A) receptor, alpha 2 , gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 2 , gamma-aminobutyric acid receptor A2 subunit , gamma-aminobutyric acid A receptor, alpha 2

GENE ID SPECIES
703894 Macaca mulatta
751992 Taeniopygia guttata
770511 Gallus gallus
100173835 Pongo abelii
100061914 Equus caballus
100170583 Xenopus (Silurana) tropicalis
100286789 Felis catus
100339376 Oryctolagus cuniculus
100546188 Meleagris gallopavo
2555 Homo sapiens
289606 Rattus norvegicus
447255 Xenopus laevis
482131 Canis lupus familiaris
282236 Bos taurus
461355 Pan troglodytes
14395 Mus musculus
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