gamma-aminobutyric Acid (GABA) A Receptor, alpha 2 Proteins (GABRA2)

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Additionally we are shipping GABRA2 Antibodies (109) and GABRA2 Kits (24) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GABRA2 2555 P47869
Rat GABRA2 GABRA2 289606  
GABRA2 14395 P26048
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Top GABRA2 Proteins at antibodies-online.com

Showing 6 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$5,355.45
Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,465.26
Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,465.26
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
$7,626.01
Details
Escherichia coli (E. coli) Human Un-conjugated SDS-PAGE analysis of Human gABRA2 Protein. 100 μg Log in to see 11 to 18 Days
$582.75
Details
Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 11 to 18 Days
$582.75
Details

GABRA2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
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Mouse (Murine) ,
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More Proteins for gamma-aminobutyric Acid (GABA) A Receptor, alpha 2 (GABRA2) Interaction Partners

Rhesus Monkey gamma-aminobutyric Acid (GABA) A Receptor, alpha 2 (GABRA2) interaction partners

  1. the developmental shift in GABA(A) receptor alpha subunit (show POLG Proteins) expression continues through adolescence in primate dorsolateral prefrontal cortex

Human gamma-aminobutyric Acid (GABA) A Receptor, alpha 2 (GABRA2) interaction partners

  1. rs505474, rs1398175, and rs4868029 in the GABRA2, GABRA4 (show GABRA4 Proteins), and GABRP (show GABRP Proteins) genes, respectively, allele frequencies were significantly different between patients and controls.Four haplotypes were significantly associated with Bipolar Disorder TA and AG for rs3815762 and rs4868029 in GABRP (show GABRP Proteins), GG for rs11636988 and rs8024256 in GABRB3 (show GABRB3 Proteins) and GAGG for rs2197414, rs4921195, rs13188991, and rs11956731 in GABRA6 (show GABRA6 Proteins).

  2. The results of the present study suggest that the GABRA2 genotype interacts with stress in young people with impact on the development of alcohol use and aggressive behaviour.

  3. GxE interaction: GABRA2 x Positive Peer Involvement on adolescent behavior.

  4. Association between GABRA2 and Alcohol Dependence was essentially limited to individuals with co-occurring Drug Dependence. The GABAA (show GABRg1 Proteins) receptor is a heteropentamer so there are multiple potential variants in either GABRA2 or other receptor subunits which might associate with the phenotypes of interest and there is also a high degree of linkage disequilibrium across the region.

  5. GABA alpha2 and/or alpha3 receptor subtypes are involved in GABAergic modulation of prolactin (show PRL Proteins) secretion.

  6. An uncorrected exploratory analysis revealed associations between GABBR2 (show GABBR2 Proteins), GABRA2 and DRD2 (show DRD2 Proteins) variants with transcranial magnetic stimulation measures of corticospinal excitability and cortical inhibition in Huntington's disease, as well as with age at onset.

  7. Our study findings showed COMT (show COMT Proteins) polymorphism conferring risk and GABRA1 (show GABRA1 Proteins) and GABRA2 polymorphism as a protective genotype for Indian male with alcohol dependence (AD)

  8. parental externalizing was associated with more life events, and the association between life events and subsequent adolescent externalizing varied as a function of GABRA2 genotype (p

  9. A GABRA2 x Parental Monitoring effect on externalizing behavior trajectory was observed, such that A-carriers were largely unaffected by parental monitoring, whereas trajectory for those with the GG genotype was affected by parental monitoring.

  10. GABRA2 SNPs directly predicted adolescent alcohol problems.

Mouse (Murine) gamma-aminobutyric Acid (GABA) A Receptor, alpha 2 (GABRA2) interaction partners

  1. Findings suggest that ovarian cycle-related progesterone and neurosteroids regulate alpha2-GABA-A receptor expression in the hippocampus via a non-progesterone receptor (show PGR Proteins) pathway, which may be relevant to menstrual-cycle related brain conditions.

  2. Results show that the expression levels of Gabra2, as well as of GABA receptor-mediated inhibitory neurotransmission, are reduced in Shank2 (show SHANK2 Proteins) e6-7, but not in e7 KO mice compared with their own wild type littermates. Shank2 (show SHANK2 Proteins) e6-7 KO mice treated with allosteric modulator for the GABAA (show GABRg1 Proteins) receptor reverses spatial memory deficits, indicating that reduced inhibitory neurotransmission may cause memory deficits in Shank2 (show SHANK2 Proteins).

  3. Pharmological manipulation by clobazam, a common anticonvulsant with preferential affinity for the GABRA2 receptor, revealed dose-dependent protection against hyperthermia-induced seizures in Scn1a (show SCN1A Proteins)+/- mice. These findings support Gabra2 as a genetic modifier of the Scn1a (show SCN1A Proteins)+/- mouse model of Dravet syndrome.

  4. Results indicate that 174 proteins were associated with gamma-aminobutyric acid receptor subunit alpha 2 (pHalpha2).

  5. Wild-type and mutant mice have similar baseline nociceptive sensitivities and develop similar hyperalgesia specifically targeting alpha2-GABAA (show GABRg1 Proteins) receptors which exert their antihyperalgesic effect through enhanced spinal nociceptive control.

  6. GABRA2 subunit expression in hippocampus modulates neurogenesis through nuclear factor of activated T cell (show NFATC3 Proteins) (NFATc)4 (show NFATC4 Proteins) activity.

  7. Disrupting the clustering of GABAA (show GABRg1 Proteins) receptor alpha2 subunits in the frontal cortex leads to reduced gamma-power and cognitive deficits.

  8. Recovery of function following alcoholic intoxication is regulated by Gabra2 and Gabra3 (show GABRA3 Proteins) receptor subunits.

  9. These findings suggest that alpha2-containing GABA(A) receptors expressed in the CA3 (show CA3 Proteins) region provide the inhibition that controls hippocampal rhythm during cholinergically induced oscillations

  10. The results of this study emphasize the critical role of GABAergic synaptic signaling for structural maturation of adult-born GCs (show UGCG Proteins) and formation of glutamatergic synapses.

GABRA2 Protein Profile

Protein Summary

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Alternatively spliced transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with GABRA2

  • gamma-aminobutyric acid type A receptor alpha2 subunit (GABRA2)
  • gamma-aminobutyric acid type A receptor alpha1 subunit (GABRA1)
  • gamma-aminobutyric acid (GABA) A receptor, alpha 2 (gabra2)
  • gamma-aminobutyric acid type A receptor alpha2 subunit (Gabra2)
  • gamma-aminobutyric acid (GABA) A receptor, alpha 2 S homeolog (gabra2.S)
  • gamma-aminobutyric acid (GABA) A receptor, alpha 2 (GABRA2)
  • gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2 (Gabra2)
  • C630048P16Rik protein
  • Gabra-2 protein

Protein level used designations for GABRA2

GABA(A) receptor subunit alpha-2 , gamma-aminobutyric acid receptor subunit alpha-2 , GABA-A receptor alpha-1 subunit , gamma-aminobutyric acid (GABA) A receptor, alpha 2 , gamma-aminobutyric acid A receptor alpha 2 , gamma-aminobutyric acid A receptor, alpha 2 precursor-like , GABA(A) receptor, alpha 2 , gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 2 , gamma-aminobutyric acid receptor A2 subunit , gamma-aminobutyric acid A receptor, alpha 2

GENE ID SPECIES
703894 Macaca mulatta
751992 Taeniopygia guttata
770511 Gallus gallus
100173835 Pongo abelii
100061914 Equus caballus
100170583 Xenopus (Silurana) tropicalis
100286789 Felis catus
100339376 Oryctolagus cuniculus
100546188 Meleagris gallopavo
2555 Homo sapiens
289606 Rattus norvegicus
447255 Xenopus laevis
482131 Canis lupus familiaris
282236 Bos taurus
461355 Pan troglodytes
14395 Mus musculus
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