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GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels.
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the developmental shift in GABA(A) receptor alpha subunit (show POLG Proteins) expression continues through adolescence in primate dorsolateral prefrontal cortex
The results of the present study suggest that the GABRA2 genotype interacts with stress in young people with impact on the development of alcohol use and aggressive behaviour.
GxE interaction: GABRA2 x Positive Peer Involvement on adolescent behavior.
Association between GABRA2 and Alcohol Dependence was essentially limited to individuals with co-occurring Drug Dependence. The GABAA (show GABRg1 Proteins) receptor is a heteropentamer so there are multiple potential variants in either GABRA2 or other receptor subunits which might associate with the phenotypes of interest and there is also a high degree of linkage disequilibrium across the region.
GABA alpha2 and/or alpha3 receptor subtypes are involved in GABAergic modulation of prolactin (show PRL Proteins) secretion.
An uncorrected exploratory analysis revealed associations between GABBR2 (show GABBR2 Proteins), GABRA2 and DRD2 (show DRD2 Proteins) variants with transcranial magnetic stimulation measures of corticospinal excitability and cortical inhibition in Huntington's disease, as well as with age at onset.
Our study findings showed COMT (show COMT Proteins) polymorphism conferring risk and GABRA1 (show GABRA1 Proteins) and GABRA2 polymorphism as a protective genotype for Indian male with alcohol dependence (AD)
parental externalizing was associated with more life events, and the association between life events and subsequent adolescent externalizing varied as a function of GABRA2 genotype (p = .05). The association between life events and subsequent adolescent externalizing was stronger for adolescents with 0 copies of the G minor allele compared to those with 1 or 2 copies of the minor allele
A GABRA2 x Parental Monitoring effect on externalizing behavior trajectory was observed, such that A-carriers were largely unaffected by parental monitoring, whereas trajectory for those with the GG genotype was affected by parental monitoring.
GABRA2 SNPs directly predicted adolescent alcohol problems.
Alcohol dependence-associated variation in GABRA2 is associated with differential expression of the entire cluster of GABAA (show GABRg1 Proteins) subunit genes on chromosome 4p12 in neural stem cells.
Findings suggest that ovarian cycle-related progesterone and neurosteroids regulate alpha2-GABA-A receptor expression in the hippocampus via a non-progesterone receptor (show PGR Proteins) pathway, which may be relevant to menstrual-cycle related brain conditions.
Results show that the expression levels of Gabra2, as well as of GABA receptor-mediated inhibitory neurotransmission, are reduced in Shank2 (show SHANK2 Proteins) e6-7, but not in e7 KO mice compared with their own wild type littermates. Shank2 (show SHANK2 Proteins) e6-7 KO mice treated with allosteric modulator for the GABAA (show GABRg1 Proteins) receptor reverses spatial memory deficits, indicating that reduced inhibitory neurotransmission may cause memory deficits in Shank2 (show SHANK2 Proteins).
Pharmological manipulation by clobazam, a common anticonvulsant with preferential affinity for the GABRA2 receptor, revealed dose-dependent protection against hyperthermia-induced seizures in Scn1a (show SCN1A Proteins)+/- mice. These findings support Gabra2 as a genetic modifier of the Scn1a (show SCN1A Proteins)+/- mouse model of Dravet syndrome.
Results indicate that 174 proteins were associated with gamma-aminobutyric acid receptor subunit alpha 2 (pHalpha2).
Wild-type and mutant mice have similar baseline nociceptive sensitivities and develop similar hyperalgesia specifically targeting alpha2-GABAA (show GABRg1 Proteins) receptors which exert their antihyperalgesic effect through enhanced spinal nociceptive control.
GABRA2 subunit expression in hippocampus modulates neurogenesis through nuclear factor of activated T cell (show NFATC3 Proteins) (NFATc)4 (show NFATC4 Proteins) activity.
Disrupting the clustering of GABAA (show GABRg1 Proteins) receptor alpha2 subunits in the frontal cortex leads to reduced gamma-power and cognitive deficits.
Recovery of function following alcoholic intoxication is regulated by Gabra2 and Gabra3 (show GABRA3 Proteins) receptor subunits.
These findings suggest that alpha2-containing GABA(A) receptors expressed in the CA3 (show CA3 Proteins) region provide the inhibition that controls hippocampal rhythm during cholinergically induced oscillations
The results of this study emphasize the critical role of GABAergic synaptic signaling for structural maturation of adult-born GCs (show UGCG Proteins) and formation of glutamatergic synapses.
GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
GABA(A) receptor subunit alpha-2
, gamma-aminobutyric acid receptor subunit alpha-2
, GABA-A receptor alpha-1 subunit
, gamma-aminobutyric acid (GABA) A receptor, alpha 2
, gamma-aminobutyric acid A receptor alpha 2
, gamma-aminobutyric acid A receptor, alpha 2 precursor-like
, GABA(A) receptor, alpha 2
, gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 2
, gamma-aminobutyric acid receptor A2 subunit
, gamma-aminobutyric acid A receptor, alpha 2