anti-gamma-aminobutyric Acid (GABA) A Receptor, gamma 2 (GABRG2) Antibodies

GABRG2 encodes a gamma-aminobutyric acid (GABA) receptor. Additionally we are shipping GABRG2 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GABRG2 29709 P18508
GABRG2 2566 P18507
GABRG2 14406 P22723
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Top anti-GABRG2 Antibodies at antibodies-online.com

Showing 10 out of 118 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC, WB Western Blot: GABA-A R gamma 2 Antibody [ABIN152532] - Rat hippocampal (Hipp) lysate showing specific immunolabeling of the ~46 kDa gamma2-subunit of GABA A Receptor. 0.1 mL Log in to see 7 to 9 Days
$485.88
Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-GABRG2 Antibody Titration: </b>1.25ug/ml<br><b>Positive Control: </b>HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Rat Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$433.13
Details
Mouse Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$481.25
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Western Blot: GABA-A R gamma 2 Antibody [ABIN152497] - 10 ug of rat brain lysate showing immunolabeling of the ~45-47 kDa GABA - A R, g2-subunit. 0.05 mL Log in to see 7 to 9 Days
$444.19
Details
Human Rabbit Un-conjugated IHC (p), WB GABRG2 antibody (Center) (ABIN654148) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10 to 11 Days
$324.50
Details
Cow Rabbit Un-conjugated WB Host: Rabbit Target Name: GABRG2 Sample Type: Esophagus Tumor lysates Antibody Dilution: 1.0ug/ml Rabbit Anti-GABRG2 Antibody Catalog Number: ARP36738_P050 Formalin Fixed Paraffin Embedded Tissue: Human Adult Brain, cerebellum  Observed Staining: Cytoplasm in hepatocytes Primary Antibody Concentration: 1:600 Secondary Antibody: Donkey anti-Rabbit-Cy3 Secondary Antibody Concentration: 1:200 Magnification: 20X Exposure Time: 0.5 – 2.0 sec 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Goat Un-conjugated EIA, WB AP20117PU-N GABRG2 antibody staining of Mouse Brain lysate at 2 µg/ml (RIPA buffer, 35 µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. 0.1 mg Log in to see 6 to 8 Days
$390.50
Details
Bat Rabbit Un-conjugated WB 100 μg Log in to see 7 to 9 Days
$493.17
Details

GABRG2 Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-GABRG2 Antibodies

  1. Human Polyclonal GABRG2 Primary Antibody for IHC, WB - ABIN152532 : Joshi, Sun, Kapur: A mouse monoclonal antibody against the γ2 subunit of GABAA receptors. in Hybridoma (2005) 2011 (PubMed)
    Show all 8 Pubmed References

  2. Human Polyclonal GABRG2 Primary Antibody for ICC, IF - ABIN152497 : Borghese, Werner, Topf, Baron, Henderson, Boehm, Blednov, Saad, Dai, Pearce, Harris, Homanics, Harrison: An isoflurane- and alcohol-insensitive mutant GABA(A) receptor alpha(1) subunit with near-normal apparent affinity for GABA: characterization in heterologous systems and production of knockin mice. in The Journal of pharmacology and experimental therapeutics 2006 (PubMed)
    Show all 6 Pubmed References

  3. Rat (Rattus) Polyclonal GABRG2 Primary Antibody for WB - ABIN361439 : Gomez, Froemke, Burden: Synaptic plasticity and cognitive function are disrupted in the absence of Lrp4. in eLife 2014 (PubMed)
    Show all 9 Pubmed References

  4. Human Monoclonal GABRG2 Primary Antibody for ICC, IP - ABIN2690511 : Kerti-Szigeti, Nusser: Similar GABAA receptor subunit composition in somatic and axon initial segment synapses of hippocampal pyramidal cells. in eLife 2016 (PubMed)

More Antibodies against GABRG2 Interaction Partners

Human gamma-aminobutyric Acid (GABA) A Receptor, gamma 2 (GABRG2) interaction partners

  1. A recurrent GABRG2 missense variant is associated with early-onset seizures, significant motor and speech delays, intellectual disability, hypotonia, movement disorder, dysmorphic features and vision/ocular issues.

  2. The aim of this case-control study is to investigate whether GABRG2 polymorphisms contribute to susceptibility for Febrile seizure and epilepsy in pooled data of three cohorts, from Malaysia (composed of Malay, Chinese, and Indian), Hong Kong, and Korea.

  3. Study utilized targeted next-gen (show GEN1 Antibodies) sequencing to identify a novel splicing variation (NM_198903.2:c.1249-1G > T) in the GABRG2 gene of a febrile seizure (FS) patient. The potential association of ten selected genetic polymorphisms in IL1RN (show IL1RN Antibodies) (86-bp VNTR), IL10 (show IL10 Antibodies) (rs1900872), PTGS2 (show PTGS2 Antibodies) (8 SNPs, rs689465, rs689466, rs20417, rs13306038, rs201931599, rs689470, rs4648306 and rs4648308) with FS was also examined.

  4. This study identified a missense de novo mutation in the GABAA (show GABRg1 Antibodies) receptor gamma2 subunit, P302L, in a patient with Dravet syndrome. The mutation has a novel pathogenic mechanism to cause defects in the conductance and gating of GABAA (show GABRg1 Antibodies) receptors, which results in hyperexcitability and contributes to the pathogenesis of the genetic epilepsy Dravet syndrome.

  5. This study demonstrated that rescue of PTZ seizure threshold and thalamocortical oscillations in a Gabrg2+/Q390X KI mouse model of Dravet syndrome/GEFS+ by overexpression of wild-type gamma2HA subunits.

  6. Defects in GABRG2/GABAergic neurotransmission participate in the pathogenesis of genetic epilepsies including epileptic encephalopathies.

  7. This review suggest that the pathogenesis of GABRG2 mutations is likely to be due to a combination of reduction of channel function and disturbance of cellular homeostasis due to the presence of mutant protein.

  8. Nova1 (show NOVA1 Antibodies) interacts with GABAARgamma2 not only in the central nervous system but also in hepatocellular carcinoma. Nova1 (show NOVA1 Antibodies)'s potential mechanism as an oncogene (show RAB1A Antibodies) may due to its interaction with GABAA (show GABRg1 Antibodies) Rgamma2.

  9. Thus, the presence of active GABA-A receptors, associated with phenotype determination via Ca(2 (show CA2 Antibodies)+)-signalling was demonstrated in differentiating human DA neurons.

  10. common variants of GABRG2, RELN (show RELN Antibodies) and NRG3 (show NRG3 Antibodies) and the GABRG2-RELN (show RELN Antibodies)-PTCH1 (show PTCH1 Antibodies) interaction networks might confer altered susceptibility to Hirschsprung disease.

Mouse (Murine) gamma-aminobutyric Acid (GABA) A Receptor, gamma 2 (GABRG2) interaction partners

  1. The results of this study suggesting that mutations like GABRG2(Q390X) may alter brain thermal regulation and precipitate seizures during temperature elevations.

  2. GABAA (show GABRg1 Antibodies) receptor (GABAAR) and the Na(+)-K(+)-2Cl(-) cotransporter (show SLC12A1 Antibodies) (NKCC1 (show SLC12A2 Antibodies)), but not the K(+)-Cl(-) cotransporter (show SLC12A4 Antibodies) (KCC2 (show SLC12A5 Antibodies)), were expressed in the terminals of the CRH (show CRH Antibodies) neurons at the median eminence (ME). In contrast, CRH (show CRH Antibodies) neuronal somata were enriched with KCC2 (show SLC12A5 Antibodies) but not with NKCC1 (show SLC12A2 Antibodies).

  3. This study demonstrated that the reduced local input to fast-spiking interneurons in the somatosensory cortex in the GABAA (show GABRg1 Antibodies) gamma2 R43Q mouse model of absence epilepsy.

  4. Heterozygous Gabrg2(+/Q390X) KI mice are associated with a severe epileptic encephalopathy due to a dominant negative effect of the mutation, while heterozygous Gabrg2(+/-) KO mice are associated with mild absence epilepsy due to simple haploinsufficiency.

  5. This investigation demonstrates striking interfacial GABAA (show GABRg1 Antibodies) receptor subunit selectivity in the native milieu, suggesting that asymmetric occupancy of heteropentameric ion channels by alkylphenol-based anesthetics is sufficient to induce modulation of activity.

  6. Study shows that the down-regulation of the gamma2 subunit of postsynaptic GABAARs in NG2 (show Vcan Antibodies) cells that accompanies the postnatal switch from synaptic to extrasynaptic GABAergic transmission between interneurons and these cells in the barrel cortex

  7. Dendritic spine abnormalities of Gabrg2+/- mice suggest association of functional defects in glutamatergic transmission with the established anxious-depressive phenotype of these mice

  8. KIF21B (show KIF21B Antibodies) participates in the delivery of GABAAR transport vesicles into dendrites.

  9. The study demonstrates the molecular and functional diversity of the GABAAR system within the mouse colon providing a framework for developing GABAAR-based therapeutics in GI disorders.

  10. these findings suggest that gephyrin (show GPHN Antibodies) may be a key factor in BDNF (show BDNF Antibodies)-dependent GABAAR regulation in the amygdala.

GABRG2 Antigen Profile

Protein Summary

This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammlian brain, where it acts at GABA-A receptors, which are ligand-gated chloride channels. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene have been associated with epilepsy and febrile seizures. Multiple transcript variants encoding different isoforms have been identified for this gene.

Gene names and symbols associated with GABRG2

  • gamma-aminobutyric acid type A receptor gamma2 subunit (GABRG2) antibody
  • gamma-aminobutyric acid (GABA) A receptor, gamma 2 (gabrg2) antibody
  • gamma-aminobutyric acid type A receptor gamma 2 subunit (Gabrg2) antibody
  • gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 (Gabrg2) antibody
  • CAE2 antibody
  • ECA2 antibody
  • GABAA-R antibody
  • Gabrg-2 antibody
  • gabrg1 antibody
  • gamma2 antibody
  • GEFSP3 antibody
  • si:ch211-145n14.1 antibody

Protein level used designations for GABRG2

gamma-aminobutyric acid A receptor, gamma 1 , GABA(A) receptor subunit gamma-2 , gamma-aminobutyric acid receptor subunit gamma-2 , gamma-aminobutyric acid A receptor gamma 2 , gamma-aminobutyric acid (GABA) A receptor, gamma 2 , gamma-aminobutyric acid receptor subunit gamma-2-like , gamma-aminobutyric acid A receptor, gamma 2 , gamma-aminobutyric acid (GABA-A) receptor, subunit gamma 2 , gamma-aminobutyric acid A receptor, gamma 2 , GABA-A receptor gamma-2 subunit , GABA(A) receptor, gamma 2

GENE ID SPECIES
100059571 Equus caballus
779514 Xenopus (Silurana) tropicalis
100174267 Pongo abelii
100286791 Felis catus
100405062 Callithrix jacchus
29709 Rattus norvegicus
553402 Danio rerio
396289 Gallus gallus
2566 Homo sapiens
489141 Canis lupus familiaris
282240 Bos taurus
100516405 Sus scrofa
14406 Mus musculus
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