anti-helicase 2, X-linked (ATRX) Antibodies

The protein encoded by ATRX contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. Additionally we are shipping ATRX Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ATRX 546 P46100
ATRX 246284  
ATRX 22589 Q61687
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Top anti-ATRX Antibodies at antibodies-online.com

Showing 10 out of 126 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IF, ELISA Immunofluorescence analysis of A549 cells, using ATRX Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated FACS, WB RAD54 Antibody (C-term) (ABIN655910) western blot analysis in NCI-H460 cell line lysates (35 µg/lane). This demonstrates the RAD54 antibody detected the RAD54 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), IP, WB Immunohistochemistry-Paraffin: ATRX Antibody [NBP1-32851] - Human lung carcinoma dilution: 1:500 Western Blot: ATRX Antibody [NBP1-32851] - Whole cell extracts (30 ug) was separated by 5% SDS-PAGE, and the membrane was blotted with ATRX antibody diluted by 1:1000. 0.1 mL Log in to see 7 to 9 Days
$514.63
Details
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged ATRX is approximately 0.1 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated ELISA, WB   100 μg Log in to see 2 to 3 Days
$302.50
Details
Dog Rabbit Un-conjugated WB Host: Rabbit Target Name: ATRX Sample Type: Jurkat Whole Cell lysates Antibody Dilution: 1.0ug/ml  ATRX is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Immunohistochemistry: ATRX Antibody [NBP1-83077] - Immunohistochemical staining of human glioma shows strong nuclear immunoreactivity in tumor cells. Immunohistochemistry: ATRX Antibody [NBP1-83077] - Immunohistochemical staining of human liver shows no positivity 0.1 mL Log in to see 10 to 13 Days
$491.63
Details
Human Rabbit Un-conjugated ICC, IF, IP, IHC (p), WB IHC-P Image Rad54 antibody [C3], C-term detects Rad54 protein at nucleus on human endometrial carcinoma by immunohistochemical analysis. Sample: Paraffin-embedded human endometrial carcinoma. Rad54 antibody [C3], C-term , dilution: 1:500. IHC-P Image Rad54 antibody [C3], C-term detects Rad54 protein at nucleus on human breast carcinoma by immunohistochemical analysis. Sample: Paraffin-embedded human breast carcinoma. Rad54 antibody [C3], C-term , dilution: 1:500. 100 μL Log in to see 1 to 2 Days
$358.60
Details
Human Rabbit Un-conjugated ELISA, IF, IHC, WB   100 μL Log in to see 16 Days
$181.73
Details
Human Rabbit Un-conjugated WB Western blot of ATRX antibody. Nuclear extract of CCF-STGG1 cells (40 µg per lane) probed with ATRX antibody (pAb) at a dilution of 1:2,500. 100 μL Log in to see 1 to 2 Days
$495.83
Details

ATRX Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , , , ,
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Rat (Rattus)


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Top referenced anti-ATRX Antibodies

  1. Human Polyclonal ATRX Primary Antibody for IHC, IHC (p) - ABIN4282398 : Heaphy, de Wilde, Jiao, Klein, Edil, Shi, Bettegowda, Rodriguez, Eberhart, Hebbar, Offerhaus, McLendon, Rasheed, He, Yan, Bigner, Oba-Shinjo, Marie, Riggins, Kinzler, Vogelstein, Hruban, Maitra et al.: Altered telomeres in tumors with ATRX and DAXX mutations. ... in Science (New York, N.Y.) 2011 (PubMed)
    Show all 16 Pubmed References

  2. Human Polyclonal ATRX Primary Antibody for ICC, IF - ABIN442805 : Wille, Maurer, Piatti, Whittle, Rieder, Singewald, Lusser: Impaired Contextual Fear Extinction Learning is Associated with Aberrant Regulation of CHD-Type Chromatin Remodeling Factors. in Frontiers in behavioral neuroscience 2015 (PubMed)
    Show all 2 Pubmed References

More Antibodies against ATRX Interaction Partners

Human helicase 2, X-linked (ATRX) interaction partners

  1. Both primary Alternative lengthening of telomeres(ALT) -positive and ATRX/DAXX (show DAXX Antibodies)-negative PanNETs are independently associated with aggressive clinicopathologic behavior and displayed reduced recurrence-free survival. In contrast, ALT activation and loss of ATRX/DAXX (show DAXX Antibodies) are both associated with better overall survival in patients with metastases

  2. Whole-exome sequencing has identified recurrent mutations in the genes DAXX (show DAXX Antibodies) and ATRX, which correlate with loss of protein expression and alternative lengthening of telomeres (ALT).ALT and DAXX (show DAXX Antibodies)/ATRX loss in PanNETs was associated with shorter disease-free survival (DFS (show FST Antibodies)) and disease-specific survival (DSS (show NR0B1 Antibodies)) and likely plays a significant role in driving metastatic disease

  3. The results of this study support an important role for ATRX loss and acquisition of ALT in the biology of NF1 (show NF1 Antibodies)-associated gliomas, particularly diffuse and high-grade tumors developing in adults.

  4. We propose that mutations in alpha thalassemia-mental retardation syndrome X-linked (ATRX)/death-domain associated protein (DAXX (show DAXX Antibodies)) prime alternative lengthening of telomeres activation by disrupting telomeric heterochromatin.

  5. Structural and biochemical characterization of DAXX (show DAXX Antibodies)-ATRX interaction.

  6. Structural basis for DAXX (show DAXX Antibodies) interaction with ATRX.

  7. Review of research progress of TERT (show TERT Antibodies)-mediated and ATRX-mediated telomere maintenance and neuroblastoma (show ARHGEF16 Antibodies), especially high-risk tumors

  8. This study demonstrated the ATRX loss in glioneuronal tumors with neuropil-like islands.

  9. 6 cases of diffuse glioma that presented a diagnostic challenge due to conflicting IDH1 (show IDH1 Antibodies)/IDH2 (show IDH2 Antibodies), ATRX, and 1p/19q results.

  10. The chromatin remodeling enzyme ATRX is a regulator of therapy induced senescence and drives cells into this state via multiple mechanisms.

Mouse (Murine) helicase 2, X-linked (ATRX) interaction partners

  1. Gene expression changes in the Atrx-null retina indicate defective synaptic structure and neuronal circuitry, suggest excitotoxic mechanisms of neurodegeneration, and demonstrate that common targets of ATRX in the forebrain and retina may contribute to similar neuropathological processes underlying cognitive impairment and visual dysfunction in ATR-X syndrome.

  2. mosaic loss of ATRX expression in the central nervous system leads to endocrine defects and decreased body size and has a negative impact on learning and memory.

  3. The results suggest that ATRX is required to limit replication stress during cellular proliferation, whereas upregulation of PARP-1 (show PARP1 Antibodies) activity functions as a compensatory mechanism to protect stalled forks, limiting genomic damage, and facilitating late-born neuron production.

  4. Our study highlights the importance of the cooperation between Rad54 (show RAD54L Antibodies) and Mus81 (show MUS81 Antibodies) for mediating DNA DSB repair and restraining chromosome missegregation.

  5. The long noncoding RNA, TERRA (show DMRT2 Antibodies) can bind both in cis (show CISH Antibodies) to telomeres and in trans to genic targets; a large network of interacting proteins was defined, including epigenetic factors, telomeric proteins, and the RNA helicase, ATRX. TERRA (show DMRT2 Antibodies) and ATRX share hundreds of target genes and are functionally antagonistic at these loci: whereas TERRA (show DMRT2 Antibodies) activates, ATRX represses gene expression.

  6. The changes of ATRX distribution occur and partially correlate with the main stages of zygotic genome activation during mouse early development, butthese changes seem to be determined by other processes of structural and functional rearrangements of blastomere nuclei.

  7. ATRX mutation is associated with increased mutation rate at the single-nucleotide variant (SNV) level.

  8. Daxx (show DAXX Antibodies) and Atrx safeguard the genome by silencing repetitive elements when DNA methylation (show HELLS Antibodies) levels are low.

  9. A direct role of Atrx in the establishment and robust maintenance of heterochromatin is demonstrated.

  10. We propose a model whereby ATRX-dependent deposition of H3.3 into heterochromatin is normally required to maintain the memory of silencing at imprinted loci.

ATRX Antigen Profile

Protein Summary

The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.

Gene names and symbols associated with ATRX

  • ATRX, chromatin remodeler (ATRX) antibody
  • ATRX, chromatin remodeler (Atrx) antibody
  • RAD54 like (S. cerevisiae) (Rad54l) antibody
  • 4833408C14Rik antibody
  • AI447451 antibody
  • ATR2 antibody
  • DXHXS6677E antibody
  • HP1-BP38 antibody
  • Hp1bp2 antibody
  • Hp1bp38 antibody
  • JMS antibody
  • MRXHF1 antibody
  • MRXS3 antibody
  • Rad54 antibody
  • RAD54L antibody
  • SFM1 antibody
  • SHS antibody
  • XH2 antibody
  • Xnp antibody
  • ZNF-HX antibody

Protein level used designations for ATRX

ATP-dependent helicase ATRX , DNA dependent ATPase and helicase , X-linked helicase II , X-linked nuclear protein , Zinc finger helicase , alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae) , helicase 2, X-linked , transcriptional regulator ATRX , alpha thalassemia/mental retardation syndrome X-linked homolog , helicase II , pABP-2 , XNP , HP1 alpha-interacting protein , alpha thalassemia/mental retardation syndrome (X-linked) , heterochromatin protein 2 , DNA repair and recombination protein RAD54-like , RAD54 homolog , mHR54 , mRAD54

GENE ID SPECIES
100455265 Pongo abelii
546 Homo sapiens
246284 Rattus norvegicus
449625 Pan troglodytes
22589 Mus musculus
19366 Mus musculus
Selected quality suppliers for anti-ATRX (ATRX) Antibodies
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