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Phosphatidylserine (PS) accounts for 5 to 10% of cell membrane phospholipids. Additionally we are shipping PTDSS1 Antibodies (45) and PTDSS1 Kits (3) and many more products for this protein.
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RYR2, PTDSS1 and AREG (show AREG Proteins) are autism susceptibility genes that are implicated in a Lebanese population-based study of copy number variations in this disease.
PSS1 mutations not only affect cellular PS levels and distribution but also lead to a more complex imbalance in lipid homeostasis by disturbing PI4P metabolism.
Gain-of-function missense mutations in the phosphatidylserine synthase 1 (PTDSS1) gene cause Lenz-Majewski syndrome.
Site-directed mutagenesis of binding sites within the Pss1 promoter demonstrated that Sp and N-Myc (show MYCN Proteins) synergistically activate Pss1 expression in astrocytes
SBEE, synthesizing PS in the binding area for PKC, participates inn (show GHRH Proteins) signal transduction. The capability of SBEE to utilize not only serine but also ethanolamine, as free exchanging base, suggests a mechanism for modulating in loco PS concentration.
elimination of either PSS1 or PSS2 (show PTDSS2 Proteins), but not both, is compatible with mouse viability
Phosphatidylserine (PS) accounts for 5 to 10% of cell membrane phospholipids. In addition to its role as a structural component, PS is involved in cell signaling, blood coagulation, and apoptosis. PS is synthesized by a calcium-dependent base-exchange reaction catalyzed by PS synthases (EC 18.104.22.168), like PTDSS1, that exchange L-serine for the polar head group of phosphatidylcholine (PC) or phosphatidylethanolamine (PE) (Sturbois-Balcerzak et al., 2001
ptdSer synthase 1
, serine-exchange enzyme I
, phosphatidylserine synthase 1
, PtdSer Synthase-1