phosphoprotein Enriched in Astrocytes 15 Proteins (PEA15)

PEA15 encodes a death effector domain-containing protein, which is a major phosphoprotein in astrocytes, and an endogenous substrate for protein kinase C.

list all proteins Gene Name GeneID UniProt
Human PEA15 PEA15 8682 Q15121
Mouse PEA15 PEA15 18611 Q62048
Rat PEA15 PEA15 364052 Q5U318
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Top PEA15 Proteins at antibodies-online.com

Showing 8 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,744.22
Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,744.22
Details
Escherichia coli (E. coli) Human Un-conjugated Figure annotation denotes ug of protein loaded and % gel used. 100 μg Log in to see 6 to 8 Days
$680.36
Details
Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 4 Days
$385.00
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$547.80
Details
Wheat germ Human GST tag 25 μg Log in to see 11 to 12 Days
$602.86
Details
Escherichia coli (E. coli) Human Un-conjugated   10 μg Log in to see 15 to 16 Days
$225.00
Details
Escherichia coli (E. coli) Human Un-conjugated   1 mg Log in to see 2 to 3 Days
$5,723.08
Details

More Proteins for phosphoprotein Enriched in Astrocytes 15 (PEA15) Interaction Partners

Human phosphoprotein Enriched in Astrocytes 15 (PEA15) interaction partners

  1. Data suggest that PED has a prominent role in HCC (show FAM126A Proteins) biology. It acts particularly on promoting cell migration and confers resistance to sorafenib treatment.

  2. PP4 (show ANXA5 Proteins) regulates breast cancer cell survival and identifies a novel PP4c (show PPP4C Proteins)-PEA15 signalling axis in the control of breast cancer cell survival.

  3. PEA15 expression was not significantly correlated with ovarian cancer antineoplastic drug resistance.

  4. Data suggest the role of the phospholipase C epsilon-Protein kinase D (show PRKD1 Proteins)-PEA15 protein-ribosomal S6 kinase (show RPS6KB1 Proteins)-IkappaB-NF-kappa B (show NFKB1 Proteins) pathway in facilitating inflammation and inflammation-associated carcinogenesis in the colon.

  5. Integrin alpha5beta1 and p53 (show TP53 Proteins) convergent pathways in the control of anti-apoptotic proteins PEA-15 and survivin (show BIRC5 Proteins) in high-grade glioma.

  6. High PED expression is associated with esophageal carcinoma.

  7. The nuclear translocation of SApErk1/ 2 apart from PEA-15 as an important mechanism to reverse senescence phenotype.

  8. Latent HCMV infection of CD34 (show CD34 Proteins) + cells protects cells from FAS (show FAS Proteins)-mediated apoptosis through the cellular IL-10 (show IL10 Proteins)/PEA-15 pathway.

  9. New therapeutic targets based around PEA-15 and its associated interactions are now being uncovered and could provide novel avenues for treatment strategies in multiple diseases.

  10. PED/PEA-15 overexpression is sufficient to block hydrogen peroxide-induced apoptosis in Ins-1E cells through a PLD-1 mediated mechanism

Mouse (Murine) phosphoprotein Enriched in Astrocytes 15 (PEA15) interaction partners

  1. PEA-15 is a protective mediator in the vasculature and acts, at least in part, by inhibiting ERK1/2-dependent nuclear signaling in vascular smooth muscle cells during neointimal hyperplasia.

  2. Data suggest that PEA-15 contributes to the specification of the cytokine pattern of activated Th cells, thus highlighting a potential new target to interfere with T cell functional polarization and subsequent immune response.

  3. PED/PEA-15 overexpression is sufficient to block hydrogen peroxide-induced apoptosis in Ins-1E cells through a PLD-1 mediated mechanism

  4. Activated astrocytes are known to clear the Abeta (show APP Proteins) deposited in the extracellular milieu, which is why they play a key role in regulating the progression of Alzheimer's disease (AD).

  5. Activation of peroxisome proliferator-activated receptor-gamma (PPARgamma (show PPARG Proteins)) represses transcription of the ped/pea-15 gene.

  6. The findings revealed a novel mechanism by which PEA-15 positively regulates Ras/ERK signaling and increases the proliferation of H-Ras-transformed epithelial cells through enhanced phospholipase D1 expression and activation.

  7. PEA-15 did not differentiate and showed markedly enhanced autophagy. In these same cells, the autophagy inhibitor 3 (show PPP1R11 Proteins)-methyladenine rescued TGF-beta1 (show TGFB1 Proteins) effect on both autophagy and myogenesis, indicating that PEA-15 mediates TGF-beta1 (show TGFB1 Proteins) effects in muscle.

  8. Data suggest that PED/PEA-15 may affect fibroblast motility by a mechanism, at least in part, mediated by ERK1/2.

  9. we propose that PEA-15 represents a novel point of convergence of the protein kinas C and MAPK/ERK (show MAPK1 Proteins) pathways under gonadotropin releasing hormone stimulation

  10. PEA-15 regulates T-cell proliferation

PEA15 Protein Profile

Protein Summary

This gene encodes a death effector domain-containing protein, which is a major phosphoprotein in astrocytes, and an endogenous substrate for protein kinase C. Studies using knockout mice suggest that this protein may protect astrocytes from TNF-induced apoptosis. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake.

Gene names and symbols associated with PEA15

  • proliferation and apoptosis adaptor protein 15 (PEA15)
  • phosphoprotein enriched in astrocytes 15A (Pea15a)
  • proliferation and apoptosis adaptor protein 15 (Pea15)
  • phosphoprotein enriched in astrocytes 15 (PEA15)
  • proliferation and apoptosis adaptor protein 15 L homeolog (pea15.L)
  • proliferation and apoptosis adaptor protein 15 (pea15)
  • Astrocytic phosphoprotein PEA-15 (pea15)
  • phosphoprotein enriched in astrocytes 15 (pea15)
  • DKFZp459O1410 protein
  • HMAT1 protein
  • HUMMAT1H protein
  • Mat1 protein
  • MAT1H protein
  • PEA-15 protein
  • PEA15 protein
  • Pea15a protein
  • PED protein
  • Pkcs15 protein

Protein level used designations for PEA15

15 kDa phosphoprotein enriched in astrocytes , Phosphoprotein enriched in astrocytes, 15kD , astrocytic phosphoprotein PEA-15 , homolog of mouse MAT-1 oncogene , phosphoprotein enriched in diabetes , mammary transforming gene 1 , phosphoprotein enriched in astrocytes 15 , phosphoprotein enriched in astrocytes 15A , Astrocytic phosphoprotein PEA-15

GENE ID SPECIES
8682 Homo sapiens
18611 Mus musculus
364052 Rattus norvegicus
510586 Bos taurus
610113 Canis lupus familiaris
705026 Macaca mulatta
734852 Xenopus laevis
100145359 Xenopus (Silurana) tropicalis
100152480 Sus scrofa
100174153 Pongo abelii
100286636 Salmo salar
100730336 Cavia porcellus
557745 Danio rerio
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