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PEA15 encodes a death effector domain-containing protein, which is a major phosphoprotein in astrocytes, and an endogenous substrate for protein kinase C.
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Data suggest that PED has a prominent role in HCC (show FAM126A Proteins) biology. It acts particularly on promoting cell migration and confers resistance to sorafenib treatment.
PP4 (show ANXA5 Proteins) regulates breast cancer cell survival and identifies a novel PP4c (show PPP4C Proteins)-PEA15 signalling axis in the control of breast cancer cell survival.
PEA15 expression was not significantly correlated with ovarian cancer antineoplastic drug resistance.
Data suggest the role of the phospholipase C epsilon-Protein kinase D (show PRKD1 Proteins)-PEA15 protein-ribosomal S6 kinase (show RPS6KB1 Proteins)-IkappaB-NF-kappa B (show NFKB1 Proteins) pathway in facilitating inflammation and inflammation-associated carcinogenesis in the colon.
Integrin alpha5beta1 and p53 (show TP53 Proteins) convergent pathways in the control of anti-apoptotic proteins PEA-15 and survivin (show BIRC5 Proteins) in high-grade glioma.
High PED expression is associated with esophageal carcinoma.
The nuclear translocation of SApErk1/ 2 apart from PEA-15 as an important mechanism to reverse senescence phenotype.
Latent HCMV infection of CD34 (show CD34 Proteins) + cells protects cells from FAS (show FAS Proteins)-mediated apoptosis through the cellular IL-10 (show IL10 Proteins)/PEA-15 pathway.
New therapeutic targets based around PEA-15 and its associated interactions are now being uncovered and could provide novel avenues for treatment strategies in multiple diseases.
PED/PEA-15 overexpression is sufficient to block hydrogen peroxide-induced apoptosis in Ins-1E cells through a PLD-1 mediated mechanism
PEA-15 is a protective mediator in the vasculature and acts, at least in part, by inhibiting ERK1/2-dependent nuclear signaling in vascular smooth muscle cells during neointimal hyperplasia.
Data suggest that PEA-15 contributes to the specification of the cytokine pattern of activated Th cells, thus highlighting a potential new target to interfere with T cell functional polarization and subsequent immune response.
Activated astrocytes are known to clear the Abeta (show APP Proteins) deposited in the extracellular milieu, which is why they play a key role in regulating the progression of Alzheimer's disease (AD).
Activation of peroxisome proliferator-activated receptor-gamma (PPARgamma (show PPARG Proteins)) represses transcription of the ped/pea-15 gene.
The findings revealed a novel mechanism by which PEA-15 positively regulates Ras/ERK signaling and increases the proliferation of H-Ras-transformed epithelial cells through enhanced phospholipase D1 expression and activation.
PEA-15 did not differentiate and showed markedly enhanced autophagy. In these same cells, the autophagy inhibitor 3 (show PPP1R11 Proteins)-methyladenine rescued TGF-beta1 (show TGFB1 Proteins) effect on both autophagy and myogenesis, indicating that PEA-15 mediates TGF-beta1 (show TGFB1 Proteins) effects in muscle.
Data suggest that PED/PEA-15 may affect fibroblast motility by a mechanism, at least in part, mediated by ERK1/2.
we propose that PEA-15 represents a novel point of convergence of the protein kinas C and MAPK/ERK (show MAPK1 Proteins) pathways under gonadotropin releasing hormone stimulation
PEA-15 regulates T-cell proliferation
This gene encodes a death effector domain-containing protein, which is a major phosphoprotein in astrocytes, and an endogenous substrate for protein kinase C. Studies using knockout mice suggest that this protein may protect astrocytes from TNF-induced apoptosis. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake.
15 kDa phosphoprotein enriched in astrocytes
, Phosphoprotein enriched in astrocytes, 15kD
, astrocytic phosphoprotein PEA-15
, homolog of mouse MAT-1 oncogene
, phosphoprotein enriched in diabetes
, mammary transforming gene 1
, phosphoprotein enriched in astrocytes 15
, phosphoprotein enriched in astrocytes 15A
, Astrocytic phosphoprotein PEA-15