PEA15 Protein
Quick Overview for PEA15 Protein (ABIN7318180)
Target
See all PEA15 ProteinsProtein Type
Origin
Source
Purity
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Purpose
- Recombinant Human Astrocytic Phosphoprotein PEA-15/PEA15 Protein
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Sequence
- Met 1-Ala130
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Characteristics
- Recombinant Human Phosphoprotein Enriched in Astrocytes of 15 kDa is produced by our E.coli expression system and the target gene encoding Met1-Ala130 is expressed.
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Sterility
- 0.2 μm filtered
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Endotoxin Level
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Not validated for activity
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phosphoprotein Enriched in Astrocytes 15 (PEA15) (AA 1-130) protein (His tag)
custom-made PEA15 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
phosphoprotein Enriched in Astrocytes 15 (PEA15) (AA 1-130) protein (His tag)custom-made PEA15 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
phosphoprotein Enriched in Astrocytes 15 (PEA15) (AA 1-130) protein (GST tag)PEA15 Origin: Human Host: Wheat germ Recombinant AP, AA, ELISA, WB
phosphoprotein Enriched in Astrocytes 15 (PEA15) protein (Myc-DYKDDDDK Tag)PEA15 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
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Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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Expiry Date
- 12 months
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- PEA15 (phosphoprotein Enriched in Astrocytes 15 (PEA15))
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Alternative Name
- PEA15
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Background
- 15 kDa Phosphoprotein Enriched in Astrocytes,Astrocytic Phosphoprotein PEA-15,PEA15,PED,Phosphoprotein Enriched in Diabetes,Astrocyticphosphoprotein PEA-15 (PEA15) is a death effector domain (DED)-containing protein. PEA15 is mainly expressed in the central nervous system, principally in astrocytes. Increased PEA15 levels affect tumorigenesis and cancer progression. PEA15 is overexpressed in breast cancers and gliomas as well as in type 2 diabetes. PEA15 blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. PEA15 also inhibits RPS6KA3 activities by holding it in the cytoplasm. In addition, PEA15 inhibits both TNFRSF6 and TNFRSF1A mediated CASP8 activity and apoptosis. At present, PEA15 expression is also a significant prognostic marker in ovarian cancer.
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Molecular Weight
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Calculated MW: 15.3 kDa
Observed MW: 12-16 kDa
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Gene ID
- 8682
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UniProt
- Q15121
Target
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