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The protein encoded by PSAT1 is likely a phosphoserine aminotransferase, based on similarity to proteins in mouse, rabbit, and Drosophila. Additionally we are shipping phosphoserine Aminotransferase 1 Antibodies (62) and phosphoserine Aminotransferase 1 Kits (11) and many more products for this protein.
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PSAT1 protein and mRNA levels were significantly associated to poor outcome to tamoxifen treatment of breast cancer.
PSAT1, which is overexpressed in ER-negative breast cancers, is activated by ATF4 and promotes cell cycle progression via regulation of the GSK3beta/beta-catenin/cyclin D1 pathway.
Data suggest that phosphoserine aminotransferase 1 (PSAT1) may be a promising anticancer therapeutic target. .
High expression of PSAT is associated with Colon Cancer.
PSAT1 expression positively correlates with the levels of phosphorylated cyclin D1 in non-small cell lung cancer.
phosphoserine aminotransferase deficiency is associated with Neu-Laxova syndrome.
A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
we propose an idea that PSAT1 may be implicated in altered serine metabolism and schizophrenia spectrum conditions.
nucleotide sequence and enzymatic activity of two isoforms generated by alternative splicing; differential expression depending upon tissue specificity and cellular proliferation status
Overexpression of phosphoserine aminotransferase is associated with colorectal cancer development
Psat1 is regulated in maintaining intracellular alpha-ketoglutarate levels and determining the fate of mouse Embryonic stem cells.
This study showed that hepatic PSAT1 expression and liver serine levels are reduced in 2 mouse strains, and that PSAT1 inhibited the expression of hepatic TRB3 in vitro and in vivo.
The protein encoded by this gene is likely a phosphoserine aminotransferase, based on similarity to proteins in mouse, rabbit, and Drosophila. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
, endometrial progesterone-induced protein
, phosphohydroxythreonine aminotransferase