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The protein encoded by PSAT1 is likely a phosphoserine aminotransferase, based on similarity to proteins in mouse, rabbit, and Drosophila. Additionally we are shipping phosphoserine Aminotransferase 1 Antibodies (58) and phosphoserine Aminotransferase 1 Kits (11) and many more products for this protein.
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PSAT1, which is overexpressed in ER-negative breast cancers, is activated by ATF4 (show ATF4 Proteins) and promotes cell cycle progression via regulation of the GSK3beta/beta-catenin (show CTNNB1 Proteins)/cyclin D1 (show CCND1 Proteins) pathway.
Data suggest that phosphoserine aminotransferase 1 (PSAT1) may be a promising anticancer therapeutic target. .
High expression of PSAT is associated with Colon Cancer.
PSAT1 expression positively correlates with the levels of phosphorylated cyclin D1 (show CCND1 Proteins) in non-small cell lung cancer.
phosphoserine aminotransferase deficiency is associated with Neu-Laxova syndrome.
we propose an idea that PSAT1 may be implicated in altered serine metabolism and schizophrenia spectrum conditions.
Overexpression of phosphoserine aminotransferase is associated with colorectal cancer development
Psat1 is regulated in maintaining intracellular alpha-ketoglutarate levels and determining the fate of mouse Embryonic stem cells.
This study showed that hepatic PSAT1 expression and liver serine levels are reduced in 2 mouse strains, and that PSAT1 inhibited the expression of hepatic TRB3 (show TRIB3 Proteins) in vitro and in vivo.
The protein encoded by this gene is likely a phosphoserine aminotransferase, based on similarity to proteins in mouse, rabbit, and Drosophila. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
, endometrial progesterone-induced protein
, phosphohydroxythreonine aminotransferase