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serine Palmitoyltransferase, Long Chain Base Subunit 1 Proteins (SPTLC1)

Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. Additionally we are shipping serine Palmitoyltransferase, Long Chain Base Subunit 1 Antibodies (116) and serine Palmitoyltransferase, Long Chain Base Subunit 1 Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SPTLC1 10558 O15269
SPTLC1 268656 O35704
Rat SPTLC1 SPTLC1 361213  
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Top serine Palmitoyltransferase, Long Chain Base Subunit 1 Proteins at antibodies-online.com

Showing 9 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
$7,626.01
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Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$5,355.45
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$547.80
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$3,223.00
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Yeast Chinese Hamster His tag   1 mg Log in to see 60 to 71 Days
$3,223.00
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Yeast Cynomolgus His tag   1 mg Log in to see 60 to 71 Days
$3,223.00
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Escherichia coli (E. coli) Mouse T7 tag,His tag 100 μg Log in to see 15 to 18 Days
$736.00
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Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 11 to 18 Days
$582.75
Details

SPTLC1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, , ,
Mouse (Murine) ,
, ,

More Proteins for serine Palmitoyltransferase, Long Chain Base Subunit 1 (SPTLC1) Interaction Partners

Arabidopsis thaliana serine Palmitoyltransferase, Long Chain Base Subunit 1 (SPTLC1) interaction partners

  1. Findings indicate that AtORM1 and AtORM2 mediation of serine palmitoyltransferase (SPT) activity differentially regulates functionally distinct ceramide synthase activities as part of a broader sphingolipid homeostatic regulatory network.

  2. The roles of the LCB2a (show SPTLC2 Proteins) and LCB2b (show SPTLC3 Proteins) subunits in sphingolipid biosyntesis in A. thaliana were studied.

Human serine Palmitoyltransferase, Long Chain Base Subunit 1 (SPTLC1) interaction partners

  1. Therefore, SPT (show AGXT Proteins) may be an attractive therapeutic anti-cancer drug target for which compound-2 may be a promising new drug.

  2. Hereditary sensory and autonomic neuropathy type 1 mutations in SPTLC1 have distinct biochemical properties, which allowed for the prediction of the clinical symptoms on the basis of the plasma sphingoid base profile.

  3. This study describe aberrant morphology of SPTLC1C133W Dorsal Root Ganglia characterized by increased neurite growth, branching, and expression of p-ERM (show ETV5 Proteins) at neuronal growth cones.

  4. A novel SPTLC2 (show SPTLC2 Proteins)-S384F variant in 2 unrelated HSAN1 families resulted in elevated plasma 1-deoxySL levels. Expression of this mutant in HEK293 cells increased 1-deoxySL formation. The substrate specificity is affected by phosphorylation at this position.

  5. Therefore, Ser331 in SPTLC1 is a crucial amino acid, which characterizes the Hereditary sensory and autonomic neuropathy type I phenotype

  6. SPTLC1 mutations cause mitochondrial abnormalities and ER stress in HSN1 cells.

  7. Endoplasmic reticulum-resident human protein serine palmitoyltransferase long chain-1 (SPTLC1) is phosphorylated at Tyr (show TYR Proteins)(164) by the tyrosine kinase ABL.

  8. The p.CYS133Trp mutation in SPTLC1 is the most common cause of hereditary and autonomic neuropathy in the United Kingdom population.

  9. SPTLC1 mutations p.S331F and p.A352V result in a reduction of serine palmitoyltransferase activity in vitro and are associated with increased levels of the deoxysphingoid in patients' plasma samples.

  10. Hereditary sensory neuropathy type 1 is caused by a gain of function mutation in SPTLC1 which causes the accumulation of two neurotoxic sphingolipids

Mouse (Murine) serine Palmitoyltransferase, Long Chain Base Subunit 1 (SPTLC1) interaction partners

  1. mice with an adipocyte-specific deletion of Sptlc1 show that de novo sphingolipid biosynthesis is required for adipocyte cell viability and normal metabolic function and that reduced de novo sphingolipid biosynthesis within adipocytes is associated with adipocyte death, adipose tissue remodeling, and metabolic dysfunction

  2. Data suggest that overexpression of serine palmitoyltransferase (Sptlc1, serine palmitoyltransferase long chain base subunit 1) to elevate de novo sphingolipid biosynthesis induces autophagy in the liver.

  3. Both Sptlc1 and Sptlc2 (show SPTLC2 Proteins) interactions are necessary for Serine palmitoyl-CoA transferase (SPT (show AGXT Proteins)) activity in vivo and SPT (show AGXT Proteins) activity directly influences plasma sphingolipid levels

  4. The expression and activities of SPT (show AGXT Proteins) in mouse liver increased significantly following fumonisin B1 treatment

  5. Physical interaction of ABCA1 (show ABCA1 Proteins) and SPTLC1 results in reduction of ABCA1 (show ABCA1 Proteins) activity and that inhibition of this interaction produces enhanced cholesterol efflux.

  6. Sptlc1 deficient mice absorb less cholesterol.

serine Palmitoyltransferase, Long Chain Base Subunit 1 (SPTLC1) Protein Profile

Protein Summary

Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate as a cofactor. The product of this gene is the long chain base subunit 1 of serine palmitoyltransferase. Mutations in this gene were identified in patients with hereditary sensory neuropathy type 1. Alternatively spliced variants encoding different isoforms have been identified.

Gene names and symbols associated with SPTLC1

  • serine palmitoyltransferase 1 (SPT1)
  • serine palmitoyltransferase 1 (AFUA_6G00300)
  • Serine palmitoyltransferase 1 (PAS_FragB_0040)
  • serine palmitoyltransferase long chain base subunit 1 (SPTLC1)
  • serine palmitoyltransferase, long chain base subunit 1 (sptlc1)
  • serine palmitoyltransferase, long chain base subunit 1 L homeolog (sptlc1.L)
  • serine palmitoyltransferase, long chain base subunit 1 (Sptlc1)
  • serine palmitoyltransferase long chain base subunit 1 (Sptlc1)
  • Afu6g00300 protein
  • ATSPT1 protein
  • AW552086 protein
  • C77762 protein
  • E030036H05 protein
  • HSAN1 protein
  • HSN1 protein
  • LBC1 protein
  • Lcb1 protein
  • RGD1306617 protein
  • serine palmitoyltransferase 1 protein
  • Spt1 protein
  • SPTI protein
  • wu:fc75h04 protein
  • wu:fp41c08 protein
  • zgc:112247 protein

Protein level used designations for SPTLC1

Serine palmitoyltransferase 1 , LCB 1 , SPT 1 , long chain base biosynthesis protein 1 , serine C-palmitoyltransferase , serine palmitoyltransferase 1 , serine-palmitoyl-CoA transferase 1 , fc75h04 , fp41c08 , SPT1 , serine palmitoyltransferase subunit 1 , Long chain base biosynthesis protein 1 , Serine-palmitoyl-CoA transferase 1 , serine palmitoyltransferase LCB1 subunit

GENE ID SPECIES
824039 Arabidopsis thaliana
3503652 Aspergillus fumigatus Af293
8196517 Komagataella pastoris GS115
10558 Homo sapiens
553981 Danio rerio
432022 Xenopus laevis
426145 Gallus gallus
484192 Canis lupus familiaris
614165 Bos taurus
268656 Mus musculus
361213 Rattus norvegicus
100689326 Cricetulus griseus
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