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serine Palmitoyltransferase, Long Chain Base Subunit 2 Proteins (SPTLC2)

SPTLC2 encodes a long chain base subunit of serine palmitoyltransferase. Additionally we are shipping serine Palmitoyltransferase, Long Chain Base Subunit 2 Antibodies (85) and serine Palmitoyltransferase, Long Chain Base Subunit 2 Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SPTLC2 9517 O15270
SPTLC2 20773 P97363
Rat SPTLC2 SPTLC2 366697  
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Top serine Palmitoyltransferase, Long Chain Base Subunit 2 Proteins at antibodies-online.com

Showing 5 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$5,262.31
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
$7,493.38
Details
Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$338.33
Details
Escherichia coli (E. coli) Mouse Un-conjugated SDS-PAGE analysis of Mouse SPTLC2 Protein. 100 μg Log in to see 11 to 18 Days
$682.25
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Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 11 to 18 Days
$582.75
Details

SPTLC2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
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Mouse (Murine) ,
,

More Proteins for serine Palmitoyltransferase, Long Chain Base Subunit 2 (SPTLC2) Interaction Partners

Human serine Palmitoyltransferase, Long Chain Base Subunit 2 (SPTLC2) interaction partners

  1. 2 families had late-onset autosomal dominant HSAN1C caused by a new variant in SPTLC2, c.547C>T, p.(Arg183Trp). The variant changed a conserved amino acid.

  2. The activities of the hLCB2a mutants were measured in the presence of ssSPTa and ssSPTb and was found that all decrease enzyme activity.

  3. Mutations in SPTLC2 are associated with increased deoxySL formation causing hereditary sensory and autonomic neuropathy type 1 (HSANI) in a familial study.

  4. Mutations in the SPTLC2 subunit of serine palmitoyltransferase cause hereditary sensory and autonomic neuropathy type I.

  5. results suggest that SPTLC2 mutations are not a common cause for genetic sensory neuropathies.

  6. an increase in transepidermal water loss is an obligatory trigger for the upregulation of serine palmitoyltransferase mRNA expression in human epidermis

  7. Results suggest that functional serine palmitoyltransferase is not a dimer, but a higher organized complex, composed of three distinct subunits (SPTLC1, SPTLC2 and SPTLC3) with a molecular mass of 480 kDa.

  8. discovery of 2 proteins, ssSPTa and ssSPTb, which each interacts with both hLCB1 and hLCB2, suggesting that there are 4 distinct human SPT isozymes.

Mouse (Murine) serine Palmitoyltransferase, Long Chain Base Subunit 2 (SPTLC2) interaction partners

  1. The expression of SPT2 was stronger in vascular smooth muscle cells and neointima of carotid arteries from knock-out mice compared to wild-type.

  2. Data suggest that overexpression of serine palmitoyltransferase (Sptlc1 and Sptlc2, serine palmitoyltransferase long chain base subunit 1/2) to elevate de novo sphingolipid biosynthesis induces autophagy in the liver.

  3. SPTLC2 knockout mice showed decreased ceramide levels in the epidermis, which impaired water-holding capacity and barrier function.

  4. Ldlr gene knockout mice with myeloid cell-specific Sptlc2 haploinsufficiency exhibited significantly less atherosclerosis than controls.

  5. Data show that LCAT activity was significantly higher in long chain base biosynthesis protein 2 (Sptlc2)+/- and sphingomyelin synthase 2 (Sms2)-/- mice, but markedly lower in ApoE-/- and Ldlr-/- mice.

  6. results suggest that Sptlc2-mediated de novo ceramide synthesis is an essential source of C18:0 and very long chain, but not of shorter chain, ceramides in the heart

  7. Inflammatory response elicited by lipopolysaccharide increases serine palmitoyltransferase activity via upregulation of Sptlc2 in macrophages.

  8. Deficiency of Sptlc2 induces necrotic lesions in gastrointestinal cells followed by atrophic change of the tissue in short term.

  9. Both Sptlc1 and Sptlc2 interactions are necessary for Serine palmitoyl-CoA transferase (SPT) activity in vivo and SPT activity directly influences plasma sphingolipid levels

  10. The expression and activities of SPT in mouse liver increased significantly following fumonisin B1 treatment.

  11. the proximal 335 bp contain initiator and downstream promoter elements, two proximal GC boxes that stimulate transcription in a cooperative manner, and several additional elements whose activity cannot be accounted for by known factor binding sites

  12. Data show that plasma from Sptlc2 knock-out mice had a significantly stronger potential for promoting cholesterol efflux from macrophages than from wild-type mice because of a greater amount of apoE in the circulation.

serine Palmitoyltransferase, Long Chain Base Subunit 2 (SPTLC2) Protein Profile

Protein Summary

This gene encodes a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I.

Gene names and symbols associated with SPTLC2

  • serine palmitoyltransferase long chain base subunit 2 (SPTLC2)
  • serine palmitoyltransferase 2 (LOC100446763)
  • serine palmitoyltransferase long chain base subunit 2 (sptlc2)
  • serine palmitoyltransferase, long chain base subunit 2 S homeolog (sptlc2.S)
  • serine palmitoyltransferase, long chain base subunit 2a (sptlc2a)
  • serine palmitoyltransferase, long chain base subunit 2 (Sptlc2)
  • serine palmitoyltransferase long chain base subunit 2 (Sptlc2)
  • AI173915 protein
  • hLCB2a protein
  • HSN1C protein
  • LCB2 protein
  • LCB2a protein
  • mKIAA0526 protein
  • NSAN1C protein
  • Pomt2 protein
  • SPT2 protein
  • SPTLC2 protein
  • zgc:110661 protein

Protein level used designations for SPTLC2

LCB 2 , SPT 2 , long chain base biosynthesis protein 2a , serine palmitoyltransferase 2 , serine palmitoyltransferase, subunit II , serine-palmitoyl-CoA transferase 2 , serine palmitoyltransferase, long chain base subunit 2 , serine palmitoyltransferase 2-like , LCB2a , long chain base biosynthesis protein 2 , protein-O-mannosyltransferase 2 , Long chain base biosynthesis protein 2 , Long chain base biosynthesis protein 2a , Serine-palmitoyl-CoA transferase 2

GENE ID SPECIES
9517 Homo sapiens
100158010 Sus scrofa
100446763 Pongo abelii
100464437 Ailuropoda melanoleuca
100566142 Anolis carolinensis
100601824 Nomascus leucogenys
423379 Gallus gallus
444190 Xenopus laevis
480403 Canis lupus familiaris
537972 Bos taurus
553646 Danio rerio
100059392 Equus caballus
20773 Mus musculus
366697 Rattus norvegicus
100689415 Cricetulus griseus
101115373 Ovis aries
100719612 Cavia porcellus
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