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The yeast 'Sterile 20' gene (STE20) functions upstream of the mitogen-activated protein kinase (MAPK) cascade. Additionally we are shipping serine/threonine Kinase 24 Antibodies (97) and serine/threonine Kinase 24 Kits (5) and many more products for this protein.
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High MST3 expression is associated with breast cancer.
This study demonistrated that MST3 kinase phosphorylates TAO1 (show TAOK2 Proteins)/2 to enable Myosin Va (show MYO5A Proteins) function in promoting spine synapse development.
This review notes that in the SOK1 (show STK25 Proteins) and MST4 (show MST4 Proteins) germinal center kinase (show MAP4K2 Proteins) III family of proteins, exon 1 encodes a 5' untranslated region, but this is not the case for MST3.
These data provide molecular understanding of the mechanism by which MO25 (show CAB39 Proteins) isoforms regulates the activity of STE20 family protein kinases.
results show that a STRADalpha-rac1-PAK1 (show PAK1 Proteins) pathway regulates cell polarity and invasion in LKB1 (show STK11 Proteins)-null cells. It also suggests that while the function of LKB1 (show STK11 Proteins) and STRADalpha undoubtedly overlap, they may also have mutually exclusive roles
mechanism of regulation of MST3
Striatin (show STRN Proteins) orchestrates the regulation of Mst3 by PP2A (show PPP2R4 Proteins).
Mst3 is up-regulated and plays an important role in hypoxia-induced apoptosis of human trophoblasts.
five crystal structures of the catalytic domain of MST3 are presented, including a complex with ADP and manganese, a unique cofactor preferred by the enzyme, and a complex with adenine.
Proteolytic activation of Mst3 by caspases.
MST3 inhibits the insulin (show INS Proteins) signalling pathway and is important in the development of insulin (show INS Proteins) resistance and impaired blood glucose levels after an HFD.
It is involved in apoptosis and serine/threonine kinase 3 (STK3 (show PKN1 Proteins)) is a recently identified caspase-6 (show CASP6 Proteins) substrate.
Using a standard two-thirds partial hepatectomy (PH) model in young and aged mice, the activity of the core kinases MST1 (show MST1 Proteins) and LATS1 increased during the early hypertrophic phase and returned to steady state levels in the proliferative phase, coinciding with activation of YAP1 (show YAP1 Proteins) target genes and hepatocyte proliferation.
Studies indicate that Hippo (Hpo (show GFER Proteins); MST1 (show MST1 Proteins)/2 in mammals) signaling pathway plays a central role in the cell fate-specification process.
Mst2 (show STK3 Proteins) is involved in bone homeostasis, functioning as a reciprocal regulator of osteoclast and osteoblast differentiation through the NF-kappaB (show NFKB1 Proteins) pathway
the TLR-Mst1 (show MST1 Proteins)-Mst2 (show STK3 Proteins)-Rac (show AKT1 Proteins) signaling axis is critical for effective phagosome-mitochondrion function and bactericidal activity
These data indicate that that inhibition of mammalian sterile 20-like kinase 1 (show STK4 Proteins) rescued cardiac fibrosis and myocardial dysfunction in chronic beta1-adrenergic receptor stimulation-induced cardiomyopathy
Phosphorylation of LC3 (show MAP1LC3A Proteins) by the STK3 (show PKN1 Proteins) and STK4 is essential for autophagy.
These results identify MST2 (show STK3 Proteins), not MST1 (show MST1 Proteins), as a critical regulator of caspase (show CASP3 Proteins)-mediated photoreceptor cell death in the detached retina and indicate its potential as a future neuroprotection target.
results reveal a novel role of Mst2 (show STK3 Proteins) in stress-dependent cardiac hypertrophy and remodeling in the adult mouse and likely human heart
CCM3 (show PDCD10 Proteins) signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations.
Mst3b, a neuron-specific homolog of the yeast kinase Ste20, is critical for axon outgrowth. Mst3b is activated in response to trophic factors, and suppressing its expression
The yeast 'Sterile 20' gene (STE20) functions upstream of the mitogen-activated protein kinase (MAPK) cascade. In mammals, protein kinases related to STE20 can be divided into 2 subfamilies based on their structure and regulation. Members of the PAK subfamily (see PAK3\; MIM 300142) contain a C-terminal catalytic domain and an N-terminal regulatory domain that has a CDC42 (MIM 116952)-binding domain. In contrast, members of the GCK subfamily (see MAP4K2\; MIM 603166), also called the Sps1 subfamily, have an N-terminal catalytic domain and a C-terminal regulatory domain without a CDC42-binding domain. STK24 belongs to the GCK subfamily of STE20-like kinases (Zhou et al., 2000
STE20-like kinase 3
, STE20-like kinase MST3
, mammalian STE20-like protein kinase 3
, serine/threonine kinase 24 (STE20 homolog, yeast)
, serine/threonine-protein kinase 24
, sterile 20-like kinase 3
, mammalian sterile twenty 3 kinase
, STE20-like kinase MST2
, mammalian STE20-like protein kinase 2
, protein kinase homolog
, serine/threonine-protein kinase 3
, serine/threonine kinase 24 (STE20 homolog)
, serine/threonine kinase 24 L homeolog